Inhibitory effect of Boerhaavia diffusa on experimental metastasis by B16F10 melanoma in C57BL/6 mice

Leyon, P.V.; Lini, C.C.; Kuttan, Girija

doi:10.1016/j.lfs.2004.06.031

Cited by 44 publications

(29 citation statements)

References 26 publications

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“…Our observation agrees with the previous results of antitumor activity of the ethanolic extract of B. variegata extract against Dalton's ascetic lymphoma (DAL) in Swiss albino mice [93] and in N-notrosodiethylamine induced experimental liver tumour in rats and human cancer cell lines [94]. Our findings are also in agreement with the previous results of many herbal drugs such as alcoholic extract of Thuja occidentalis [95], aqueousmethanol (3:7) extract of Boerhaavia diffusa [96], methanolic extract of Withania somnifera roots [97], naturally occurring allyl and phenyl isothiocyanates [98], curcumin [99], sulphorafane [100], B. variegata leaf extract [101], Piper longum against A549 cell line [102], Cinnamaldehyde and eugenol [103] etc. have been reported to inhibit metastasis.…”

Section: Discussionsupporting

confidence: 93%

In vivo antitumor potential of extracts from different parts of Bauhinia variegata linn. Against b16f10 melanoma tumour model in c57bl/6 mice

Pandey

2017

Appl Cancer Res

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Background: Melanoma is a metastatic type of skin cancer that is difficult to treat and the majority of efforts are directed to the design of new drugs. Medicinal Plants have been the primary source of medicines since life on earth; more than 50% of existing cancer treatments is derived from plants. Bauhinia variegata is well-known medicinal plant used from the ancient era to till date for their medicinal values. Scientific literatures have not documented any evidence of the antitumour potential of Bauhinia variegata against B16F10 melanoma tumor model in C57BL mice. The present investigation was undertaken to explore the antitumour activity of Leaf, stem bark and flower extract of Bauhinia variegata against B16F10 melanoma tumour model in C57BL mice. Methods: Hydro-methanolic extract prepared from the leaf, stem bark and flower of Bauhinia variegata were assessed for their antitumor activity. The extracts at doses of 500 and 750 mg/kg b.wt. were given orally along with cyclophosphamide (chemotherapeutic drug) for 40 days for exploring antitumor activity against melanoma tumor (B16F10) in C57BL mice. Inhibition of tumor growth, increase in survival time of animal with treatment, histopathological studies and antioxidant parameter were determined. Results: The Present investigation showed significant effect of the B. variegata L. in preventing melanoma tumor by B16F10 cell line in C57BL/6 mice. As compared with the tumour control group, the remarkable results especially in the group which received B. variegata extract and cyclophosphamide together were obtained for all of the measured parameters. Dose dependent response was observed in tumor volume, inhibition rate, life span time and antioxidant parameter of extracts. Combination treatment of cyclophosphamide and B. variegata extracts showed more pronounced effect. Conclusions: These findings suggest that B. variegata hydromethanolic extract may contain bioactive compounds of potential therapeutic significance which are relatively safe from toxic effects, and can compromise the medicinal use of this plant in folk medicine.

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Section: Discussionsupporting

confidence: 93%

In vivo antitumor potential of extracts from different parts of Bauhinia variegata linn. Against b16f10 melanoma tumour model in c57bl/6 mice

Pandey

2017

Appl Cancer Res

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“…The hydroalcoholic extract and an alkaloid (termed punarnavine) derived from this plant inhibit the metastatic progression of melanoma in mice (Manu & Kuttan, 2009;Leyon et al, 2005). In addition, the hydroalcoholic extract prevents skin carcinogenesis induced by 7,12-dimethylbenz(a)anthracene (DMBA) in mice (Bharali et al, 2003).…”

Section: Boerhavia Diffusa L Nyctaginaceaementioning

confidence: 99%

Phytochemical and pharmacological notes of plants indicated to treat tumors in Brazil

Melo¹,

Santos²,

Amorim³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The plants used in traditional medicine have been considered an important source of molecules with pharmacological activity, including antitumor. The aim of this study was to present a pharmacological description and the phytochemical components related to antitumor activity of thirty plants commonly cited in Brazil to treat tumors as well as offering an overview of approaches that are necessary for the development of herbal medicines from these resources. In the search for studies with these plants, fi ve database were used (SciELO, Scirus, Scopus, Biological Abstracts and Web of Science), with the following keywords: tumor AND Species AND cancer. We consider all the scientifi c synonyms of species available in the Tropicos ® database (http://www.tropicos. org/). We surveyed papers from the period between 1980 and 2008. Twnety one species (70%) have at least one evaluation of a class of molecule or metabolite isolated against a pharmacological model. Most species (60%) has in vivo studies. Of the thirty plant species, two stood out for having pharmacological studies in vitro, in vivo and clinical with positive results: Chelidonium majus L., Papaveraceae, and Aloe arborescens Mill., Xanthorrhoeaceae. Although there is generally a good activity of species presented here, there is a need for further studies in order to evaluate the possibility of developing some byproduct.

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“…The role of MMP-9 in melanoma progression is less clear. The expression pattern of MMP-9 in human melanoma suggests a role in early transformation [51,52]; in syngeneic mouse melanoma models, however, a correlation of MMP-9 to the metastatic phenotype is suspected [53,54]. Activities from stromal cells are also important for melanoma progression: MMP-9 and uPA from macrophages and tumor cells, respectively, promote the progression of melanoma cells in a syngeneic mouse model [55].…”

Section: Role In Cmm Progressionmentioning

confidence: 99%

Proteases in cutaneous malignant melanoma: relevance as biomarker and therapeutic target

Frőhlich

2010

Cell. Mol. Life Sci.

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Cutaneous malignant melanoma is the most aggressive skin cancer. It is also the most rapidly spreading cancer in terms of worldwide incidence. Although it is detected by simple inspection and can be relatively easily removed or treated, differential diagnosis to other melanocytic lesions, lack of prognostic markers, and no efficient treatment of advanced melanoma pose problems. Detection and targeting of proteases may represent a useful tool since they play a role in tumor cell metabolism, invasion, angiogenesis and metastasis. This review gives an overview of the role of proteases in development and progression of cutaneous malignant melanoma. In addition, regulation, activation, and interaction of proteases and their inhibitors are explained for tumors in general. The potential use of proteases as differential markers for melanoma mimicking melanocytic lesions, as biomarkers in tissues, and as prognostic serum markers is discussed. Current and future possibilities to target tumor proteases in therapy are presented.

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Inhibitory effect of Boerhaavia diffusa on experimental metastasis by B16F10 melanoma in C57BL/6 mice

Cited by 44 publications

References 26 publications

In vivo antitumor potential of extracts from different parts of Bauhinia variegata linn. Against b16f10 melanoma tumour model in c57bl/6 mice

In vivo antitumor potential of extracts from different parts of Bauhinia variegata linn. Against b16f10 melanoma tumour model in c57bl/6 mice

Phytochemical and pharmacological notes of plants indicated to treat tumors in Brazil

Proteases in cutaneous malignant melanoma: relevance as biomarker and therapeutic target

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