An Experimental Method for Determining the Hildebrand Solubility Parameter of Organic Nonelectrolytes

Lin, Ho-Meei; Nash, Robert A.

doi:10.1002/jps.2600821001

Cited by 34 publications

(28 citation statements)

References 26 publications

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“…b Experimental data taken from Beerbower et al (1984). c Experimental data taken from Lin and Nash (1993). solubility order is noted in the two butanol solvents. Measured solubilities in the alcohol solvents do fall within a narrow mole fraction range, particularly if 2-methyl-1-propanol is excluded.…”

Section: Resultsmentioning

confidence: 99%

Solubility of 2-Hydroxybenzoic Acid in Select Organic Solvents at 298.15 K

et al. 1999

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Experimental solubilities are reported for 2-hydroxybenzoic acid dissolved in 1-propanol, 2-propanol, 1-butanol, 2-butanol, 2-methyl-1-propanol, 2-methyl-2-propanol, 1-pentanol, 1-octanol, dibutyl ether, 1,4-dioxane, tetrahydrofuran, ethyl acetate, butyl acetate, 2-propanone, 2-butanone, and cyclohexanone at 298.15 K. Results of these measurements reveal that the observed solubilities in the eight alcohol solvents fall within a fairly narrow mole fraction range of each other. 2-Hydroxybenzoic acid is more soluble in both 1,4-dioxane and tetrahydrofuran than in any of the other alcohol, ester, or ketone solvents studied.

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Section: Resultsmentioning

confidence: 99%

Solubility of 2-Hydroxybenzoic Acid in Select Organic Solvents at 298.15 K

et al. 1999

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“…The value of Hildebrand solubility of PMMA and PS are 9.3 cal 1/2 and 9.1 cal 1/2 cm -3/2 . Hildebrand solubility values approaching solvent PS and PMMA is ethyl acetate (9.1 cal 1/2 cm -3/2 ) [15][16][17][18]. Solubility process is controlled by the solubility of the polymer chain tangling or by diffusion through the boundary layer adjacent to the polymer-solvent interface [19].…”

Section: Design Of Indicator Strip From Polymers By Specific Chemicalmentioning

confidence: 99%

Design of Indicator Strip Using Polystyrene (PS) and Polymethylmethacrylate (PMMA) for Detection of Diclofenac Sodium in Traditional Pain Relief Herbal Medicines

2017

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“…Relationships of Drug Solubility Parameter and Cosolvent Action The experimental solubility parameter of a drug d 2 can be determined from the Lin and Nash method, 25) using the solubility mole fraction of the drug X 2i in three or five pure solvents of known solubility parameters d 1i : Water, ethanol and ethyl acetate were used here ( Table 5). The values of d 2 calculated from the Fedors group contribution method 26) are higher (Table 5) and nearer the solubility peak found in the more polar mixture (ethanol-water).…”

Section: )mentioning

confidence: 99%

“…Figure 8 shows a sample of the solubility profiles predicted at b) Experimental value from the Lin and Nash method. 25) c) No peak in ethanol-water. 25°C for MTZ, and MBZ and TBZ.…”

Section: )mentioning

confidence: 99%

Solubility Behavior and Prediction for Antihelmintics at Several Temperatures in Aqueous and Nonaqueous Mixtures

Bustamante

Muela

Escalera

et al. 2010

CHEMICAL & PHARMACEUTICAL BULLETIN

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Solubility is a fundamental physico-chemical property with important applications to biological, chemical, pharmaceutical and environmental industries. Reliable solubility data require careful experimental measurements that are tedious, time consuming and costly, and this research area needs further investigation.1) Solubility data for drugs in solvent mixtures at several temperatures are scarce, in particular in solvent mixtures.2-7) These data allow to obtain thermodynamic magnitudes that provide a better understanding of the co-solvent action and solute-solvent interactions. [2][3][4][5][6]8) Aqueous mixtures are often used to increase the solubility of drugs. Non-aqueous mixtures have application in synthesis, re-crystallization and purification of drugs and in some techniques of microencapsulation. 9,10) The solubility data also serve to construct mathematical models that help to optimize solvent composition selection in pharmaceutical technology. Many drug candidates are so hydrophobic that its bioavailability depends on techniques to enhance the aqueous solubility.11) During the earlier stages of drug development the amount available of drug is often restrictive. Therefore it is desirable to have a model for correlating and predicting drug solubility from a small amount of data being at the same time easy to apply. Solubility prediction is very difficult because it depends on a large number of factors such as chemical structure, solute-solvent interactions and temperature. The drugs usually form non-ideal solutions with the solvents of pharmaceutical interest, and semi-empirical or empirical approaches are often needed to obtain useful solubility prediction. Solubility modelling may significantly reduce the experimental work in solvent selection.Predictive methods often require a number of physicochemical parameters and relatively complicate computation, and low prediction capability has been reported for the universal functional group activity coefficient (UNIFAC) method in some compounds.1) The log-linear model of Yalkowsky is not applicable for drugs showing a solubility maximum, and a model was developed to account for deviations from linearity in ethanol-water mixtures.12) In fact, when solubility behaviour of drugs is studied within a wide polarity range, curves with one or two solubility peaks may be found. 6)Mota et al. 11) used the Non-random Two Liquid Segment Activity Coefficient (NRTL-SAC) model for predicting the solubility in pure solvents and solvent mixtures at 25-40°C. The model requires the melting data from the solid phase, T f , DH f and DC p . Limited experimental DC p values are available for drugs and this contribution is frequently ignored in solubility calculations.11) The predictions did not agree well with the experimental data of paracetamol at high ethanol-in water ratios, a fact that was attributed to the appearance of a peak in the solubility profile, as was earlier reported. 13,14) Bustamante and co-workers proposed a model to predict the solubility mole fraction ln X 2 of ...

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An Experimental Method for Determining the Hildebrand Solubility Parameter of Organic Nonelectrolytes

Cited by 34 publications

References 26 publications

Solubility of 2-Hydroxybenzoic Acid in Select Organic Solvents at 298.15 K

Solubility of 2-Hydroxybenzoic Acid in Select Organic Solvents at 298.15 K

Design of Indicator Strip Using Polystyrene (PS) and Polymethylmethacrylate (PMMA) for Detection of Diclofenac Sodium in Traditional Pain Relief Herbal Medicines

Solubility Behavior and Prediction for Antihelmintics at Several Temperatures in Aqueous and Nonaqueous Mixtures

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