An experimental model for studies on delayed tooth replantation and ankylosis in rabbits

Abstract

The rabbit tooth model may be useful for experimental in-vivo studies on delayed replantation, subsequent ankylosis, osseous replacement and infraposition.

The effect of cathepsin K inhibitor surface treatment on delayed tooth replantation in dogs

“…16 Furthermore, root surface resorption following trauma can be a serious outcome of avulsed teeth; 16 Furthermore, root surface resorption following trauma can be a serious outcome of avulsed teeth;…”

Effect of periodontal ligament removal with gauze prior to delayed replantation in rabbit incisors on rate of replacement resorption

“…19 No antibiotics were given. There was no need for splinting as the teeth were stable in the socket after replantation, which was confirmed from the previous study findings.…”

“…16,17 Surface application of bisphosphonates (eg, zoledronate and alendronate) has been shown to reduce root resorption of replanted teeth in animal models. In the previous study conducted by Maslamani et al 19 in 2016, ankylosis was experimentally induced on the lingual side of rabbit incisors subjected to delayed replantation. 10 It is, however, important to remember that there has been no study on the rate of resorption comparing removal and non-removal of PDL prior to replantation.…”

“…19 A small amount of bone overlying the lateral aspect of the incisors was removed with a periosteal elevator enabling the incisors to be luxated laterally, after which they were extracted along the long axis of the teeth. To ensure complete comfort during and after the experimental procedures and for vasoconstriction purposes, general anaesthesia was supplemented with local anaesthesia, 1 mL lidocaine hydrochloride 2% with adrenaline 5 μg/mL (Xylocaine-adrenaline, Dentsply, Weybridge, UK) administered as infiltration anaesthesia in the experimental area.…”

“…To ensure complete comfort during and after the experimental procedures and for vasoconstriction purposes, general anaesthesia was supplemented with local anaesthesia, 1 mL lidocaine hydrochloride 2% with adrenaline 5 μg/mL (Xylocaine-adrenaline, Dentsply, Weybridge, UK) administered as infiltration anaesthesia in the experimental area. 19 Sixteen teeth were subjected to extraction and endodontic treatment prior to delayed replantation. A small vertical incision was made in the soft tissue distal to the maxillary incisors to expose the overlying lateral alveolar bone.…”