An experimental study about the application of Gadolinium oxide nanoparticles in magnetic theranostics

Alizadeh, Mohammad; Kariminezhad, Hasan; Monfared, Ali Shabestani; Mostafazadeh, Amrollah; Amani, Hossein; Niksirat, Fatemeh; Pourbagher, Roghayeh

doi:10.1088/2053-1591/ab0ce3

Cited by 16 publications

(3 citation statements)

References 20 publications

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“…[5,6] In clinical MRI studies, the positive contrast agent T 1 commonly used is based on the complex substances of paramagnetic Gd 3 + with 7 unpaired electrons 4 f that create a large magnetic moment (7.94 μB). [7][8][9][10][11] These complex substances have linear or cyclic structures such as gadopentetate (trade name is Magnevist), gadobenate (Multihance), gadodiamide (Omniscan), gadoteridole (Prohance), or gadobutrol (Gadovist). [9] Although Gd is considered safe when used as a chelated compound, the use of some chelates Gd in people with kidney disease has been linked to a rare but serious complication called "nephrogenic systemic fibrosis".…”

Section: Introductionmentioning

confidence: 99%

“…However, the main limitation of these diagnostic techniques is their relatively low sensitivity, so many cases require the use of contrast agents to improve image quality [5,6] . In clinical MRI studies, the positive contrast agent T 1 commonly used is based on the complex substances of paramagnetic Gd 3+ with 7 unpaired electrons 4 f that create a large magnetic moment (7.94 μB) [7–11] . These complex substances have linear or cyclic structures such as gadopentetate (trade name is Magnevist), gadobenate (Multihance), gadodiamide (Omniscan), gadoteridole (Prohance), or gadobutrol (Gadovist) [9] .…”

Section: Introductionmentioning

confidence: 99%

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Multimodal Imaging Contrast Property of Nano Hybrid Fe₃O₄@Ag Fabricated by Seed‐Growth for Medicinal Diagnosis

Nguyen

et al. 2022

ChemistrySelect

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Multimodal imaging, which integrates different imaging modalities, is emerging as a promising strategy to improve both preclinical and subclinical imaging. Computed tomography (CT) and magnetic resonance imaging (MRI) are among the imaging techniques widely used in clinical practice. These imaging modalities are used to diagnose and screen disease, each providing additional and different information about the patient and pathosis. In this research, we present the development of a model that combines a hybrid nanostructure, consisting of an iron oxide core and a silver‐shell nanoparticle for dual MRI/CT imaging. Fe3O4@Ag HNPs with core‐shell structure were fabricated by reducing Ag+ on the surface of Fe3O4 (NPs) nanoparticles by seed‐growth route in the thermal decomposition method. TEM images show that the synthesized nanoparticles have a uniform spherical shape and size, with an average diameter of 15.6 nm. The hybrid nanoparticles after functionalizing the surface with polyacrylic acid (PAA) became hydrophilic and dispersed well in water. The fluid of Fe3O4@Ag@PAA HNPs has high stability in water media with NaCl salt concentrations above 200 mM and a wide pH range from 4 to 11. The fluid Fe3O4@Ag@PAA has selective cytotoxicity with IC50 value 8.42 ug/ml for Hep‐G2 cell lines, and 40.3 ug/ml for normal Vero cell lines. The results of in‐vitro MRI/CT imaging showed that the value of transverse relaxation rate r2 was 138.6 mM−1s−1 and had good X‐ray attenuation ability. With these outstanding properties, the core‐shell structured nano hybrid fluid presented in this research has the potential as a candidate for multimodal bioimaging techniques in practical applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multimodal Imaging Contrast Property of Nano Hybrid Fe₃O₄@Ag Fabricated by Seed‐Growth for Medicinal Diagnosis

Nguyen

et al. 2022

ChemistrySelect

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“…The Gd 3+ ion carries a large spin magnetic moment (S = 7/2) which makes the gadolinium-based composite materials interesting [1]. They have found their applications in a variety of fields including magnetic coolers [2], high-performance conductors [3], supercapacitors electrodes [4], optoelectronics [5], and magnetic resonance imaging(MRI) [6,7]. A very recent review report has highlighted the spintronic potential of the Gd 3+ composites in the ferroic-order [ferromagnetic, ferroelectric, and multiferroic] oxides [8].…”

Section: Introductionmentioning

confidence: 99%

Band gap and pseudocapacitance of Gd₂O₃ doped with Ni_0.5Zn_0.5Fe₂O₄

Azeem¹,

Abbas²,

Abdelkareem³

et al. 2022

Phys. Scr.

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Herein, we present a detailed study on the structural, optical, and electrochemical responses of Gd2O3 doped with nickel zinc ferrite nanoparticles. Doping of Ni0.5Zn0.5Fe2O4 nanoparticles to Gd2O3 powder was done through thermal decomposition at 1000 ֯C. The average grain size of the mixture was determined to be approximately 95 nm, and phases of cubic Gd2O3, GdO, and orthorhombic prisms of GdFeO3 were identified. The focused ion beam energy dispersive X-ray spectrum (FIB-EDX) mapping results clearly show the morphology of the particles with Gd and Fe as the dominant elements. The structural data were compared with the spectroscopic measurements confirming the formation of multiple phases of oxides and ferrites. The optical band gap is determined to be at 1.8 eV by diffuse reflectance spectroscopy, which is significantly redshifted compared to the band gap of Gd2O3 and is close to that of nitride compounds of rare earth metals. The measured specific capacitance was almost 7 Fg-1 at a current density of 1 Ag-1, showing a small drop of 27% when the current density is increased to 10 Ag-1. Cyclic voltammetry (CV) plots of the ferrite doped Gd2O3 electrode at a scan rate of 5 to 100 mV/s indicate the pseudocapacitive nature of the material.

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Photo‐ and Magnetothermally Responsive Nanomaterials for Therapy, Controlled Drug Delivery and Imaging Applications

et al. 2020

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Hyperthermia generates heat as a cure for illness and it is not a chemical treatment. Nanomaterials are supposed to provide novel mechanisms to tackle photothermal and magnetothermal problems, with the potential also to deal with specific approaches to care. The present review outlines recent developments in the field of photothermal and magnetothermal responsive nanomaterials and the photothermal approach mechanism over the last years. These photo/magnetothermal nanomaterials are classified into gold nanostructures (various shapes), carbon nanomaterials (CNTs, fullerene, carbon quantum dots, and graphene), inorganic nanomaterials (Fe, Pt, Pd, Bi, MOF, MoSe2, inorganic quantum dots, etc.) and organic nanoparticles (PLGA (Poly Lactic‐co‐Glycolic Acid) and other nanopolymers). Different groups may be placed together to improve the potential of the photothermal/magnetothermal effects, treatments, drug delivery, and imaging. The review also describes synthesis strategies for photothermal/magnetothermal nanomaterials, physicochemical characterization, the role of size, size distribution, shape, and surface coating of nanomaterials, challenges, and future scopes of photothermal/magnetothermal responsive nanomaterials for therapy, controlled drug delivery, and imaging applications. The recent development in nanomaterial has shown great potential for tumor diagnostic and therapeutic applications in hyperthermia. Magnetic hyperthermia (also called thermal therapy or thermotherapy) is a type of cancer treatment in which body tissue is exposed to high temperatures (up to 41 °C) in presence of a magnetic field. Research has shown that high temperatures can damage and kill cancer cells, usually with minimal injury to normal tissues. By killing cancer cells and damaging proteins and structures within cells, hyperthermia can necrotize tumor cells. This treatment can be local, regional, or whole‐body hyperthermia, depending on the extent of the area being treated. Hyperthermia can be combined with anticancer drugs or chemotherapy to enhance cancer treatment. In this article, we have discussed recent nanomaterials utilized for this treatment, mechanism, and synthesis methods.

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An experimental study about the application of Gadolinium oxide nanoparticles in magnetic theranostics

Cited by 16 publications

References 20 publications

Multimodal Imaging Contrast Property of Nano Hybrid Fe₃O₄@Ag Fabricated by Seed‐Growth for Medicinal Diagnosis

Multimodal Imaging Contrast Property of Nano Hybrid Fe₃O₄@Ag Fabricated by Seed‐Growth for Medicinal Diagnosis

Band gap and pseudocapacitance of Gd₂O₃ doped with Ni_0.5Zn_0.5Fe₂O₄

Photo‐ and Magnetothermally Responsive Nanomaterials for Therapy, Controlled Drug Delivery and Imaging Applications

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An experimental study about the application of Gadolinium oxide nanoparticles in magnetic theranostics

Cited by 16 publications

References 20 publications

Multimodal Imaging Contrast Property of Nano Hybrid Fe3O4@Ag Fabricated by Seed‐Growth for Medicinal Diagnosis

Multimodal Imaging Contrast Property of Nano Hybrid Fe3O4@Ag Fabricated by Seed‐Growth for Medicinal Diagnosis

Band gap and pseudocapacitance of Gd2O3 doped with Ni0.5Zn0.5Fe2O4

Photo‐ and Magnetothermally Responsive Nanomaterials for Therapy, Controlled Drug Delivery and Imaging Applications

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Product

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Multimodal Imaging Contrast Property of Nano Hybrid Fe₃O₄@Ag Fabricated by Seed‐Growth for Medicinal Diagnosis

Multimodal Imaging Contrast Property of Nano Hybrid Fe₃O₄@Ag Fabricated by Seed‐Growth for Medicinal Diagnosis

Band gap and pseudocapacitance of Gd₂O₃ doped with Ni_0.5Zn_0.5Fe₂O₄