An Experimental Study on Repeated Brief Ischemia in Promoting Sciatic Nerve Repair and Regeneration in Rats

Zhou, Xiujuan; Zou, Dequan; Gu, Wei; Wang, Dong; Feng, Jianshu; Wang, Jiangyong; Zhou, Junlin

doi:10.1016/j.wneu.2018.01.125

Cited by 6 publications

(6 citation statements)

References 35 publications

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“…The induction of hypoxia-inducible factor 1α (HIF1α) by deleting or pharmacologically inhibiting prolyl hydroxylase domain proteins, mimicking systemic hypoxia, enhances axonal regeneration and functional recovery following peripheral nerve injury [101]. In line with these findings, a positive effect of repeated brief ischemia in sciatic nerve transection injury has been found in a rat model and attributed to increased levels of vascular endothelial growth factor (VEGF) and Schwann cell proliferation in the ischemic environment [102] (Table 1).…”

Section: Repercussions Of Ischemia/hypoxia On Nerve Regeneration and ...mentioning

confidence: 85%

Role of Oxygen and Its Radicals in Peripheral Nerve Regeneration: From Hypoxia to Physoxia to Hyperoxia

André-Lévigne,

Pignel,

Boet

et al. 2024

IJMS

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Oxygen is compulsory for mitochondrial function and energy supply, but it has numerous more nuanced roles. The different roles of oxygen in peripheral nerve regeneration range from energy supply, inflammation, phagocytosis, and oxidative cell destruction in the context of reperfusion injury to crucial redox signaling cascades that are necessary for effective axonal outgrowth. A fine balance between reactive oxygen species production and antioxidant activity draws the line between physiological and pathological nerve regeneration. There is compelling evidence that redox signaling mediated by the Nox family of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases plays an important role in peripheral nerve regeneration. Further research is needed to better characterize the role of Nox in physiological and pathological circumstances, but the available data suggest that the modulation of Nox activity fosters great therapeutic potential. One of the promising approaches to enhance nerve regeneration by modulating the redox environment is hyperbaric oxygen therapy. In this review, we highlight the influence of various oxygenation states, i.e., hypoxia, physoxia, and hyperoxia, on peripheral nerve repair and regeneration. We summarize the currently available data and knowledge on the effectiveness of using hyperbaric oxygen therapy to treat nerve injuries and discuss future directions.

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Section: Repercussions Of Ischemia/hypoxia On Nerve Regeneration and ...mentioning

confidence: 85%

Role of Oxygen and Its Radicals in Peripheral Nerve Regeneration: From Hypoxia to Physoxia to Hyperoxia

André-Lévigne,

Pignel,

Boet

et al. 2024

IJMS

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“…The SD rat has 6 segments of lumbar vertebrae and 4 segments of sacral vertebrae. The spinal cord of SD rats is shorter than the spinal canal, which is similar to that of humans (Zhou et al, 2018). After the nerve roots are emitted, they travel a certain distance in the spinal canal before they can pass through the corresponding intervertebral foramen and four pairs of sacral nerves (S1-S4) penetrate the sacral foramen.…”

Section: Anatomical Characteristics Of Lumbosacral Nerve Roots and Lu...mentioning

confidence: 94%

“…In this study, when we administered a standardized crush injury to the lumbar 5 nerve roots of SD rats, axon continuity was lost, which resulted in Waller's degeneration of distal injury. Early intervention inhibited the high-frequency stimulation of afferent nerves and decreased the transmission of pain to the higher central (Zhou et al, 2018). Bendszus et al (2004) studied the electrophysiology of rat sciatic nerve during controlled degeneration and regeneration after ligation.…”

Section: Evaluation Of Nerve Function In Rat Lumbosacral Nerve Root C...mentioning

confidence: 99%

Electrophysiological, biomechanical, and finite element analysis study of sacral nerve injury caused by sacral fracture

Jiang

et al. 2022

Front. Bioeng. Biotechnol.

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Background: We aimed to study the mechanism of sacral nerve injury caused by sacral fractures and the relationship between nerve decompression and nerve function.Methods: First, we observed the anatomical features of lumbosacral nerve root region in Sprague-Dawley rats. Next, the rats were divided into the sham, 10 g, 30 g, and 60 g groups for electrophysiological studies on nerve root constriction injury. Then we studied the biomechanical properties of rat nerve roots, lumbosacral trunk, and sacrum. Finally, we established a finite element analysis model of sacral nerve roots injury in rats and determined the correlation between sacral deformation and the degree of sacral nerve roots injury.Result: Anatomical study showed L5 constitutes sciatic nerve, the length of the L5 nerve root is 3.67 ± 0.15 mm, which is suitable for electrophysiological research on nerve root compression injury. After a series of electrophysiological study of L5 nerve roots, our results showed that nerve root function was almost unaffected at a low degree of compression (10 g). Nerve root function loss began at 30 g compression, and was severe at 60 g compression. The degree of neurological loss was therefore positively correlated with the degree of compression. Combining biomechanical testing of the lumbosacral nerve roots, finite element analysis and neuroelectrophysiological research, we concluded when the sacral foramina deformation is >22.94%, the sacral nerves lose function. When the compression exceeds 33.16%, early recovery of nerve function is difficult even after decompression.Conclusion: In this study, we found that the neurological loss was positively correlated with the degree of compression. After early decompression, nerve root function recovery is possible after moderate compression; however, in severe compression group, the nerve function would not recover. Furthermore, FEA was used to simulate nerve compression during sacral fracture, as well as calculate force loading on nerve with different deformation rates. The relationship between sacral fractures and neurological loss can be analyzed in combination with neurophysiological test results.

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“…Then, when the inferior neuron had a certain change due to damage of the superior neuron, its axon regeneration may be affected accordingly. Moreover, Zhou et al (2018) also reported that accompanied by brain injury, regeneration of sciatic nerve injury in rats could also be promoted. Therefore, this study experimentally designed the sciatic nerve injury model group with ipsilateral and contralateral brain injury, which was used to observe whether there is any difference in effect on functional recovery and histo-morphology of damaged sciatic nerve.…”

Section: Introductionmentioning

confidence: 98%

“…Many studies (Eggers et al, 2016;Li and Cao, 2000;Liu et al, 2013;Yang et al, 2015) have shown that traumatic brain injury could up-regulate the neurotrophic factors, some of which could promote regeneration of peripheral nerve damage, such as neurotrophin-4/5, brain-derived neurotrophic factor. The previous experimental findings indicate that accompanied by the brain injury, regeneration of sciatic nerve injury in rats could be promoted (Zhou et al, 2018). This study aimed to explore whether there are differences in effects of brain injury at different locations on repair and regeneration of sciatic nerve.…”

Section: Introductionmentioning

confidence: 98%

Investigation for the correlation between brain injury and injured ipsilateral sciatic nerve regeneration in a rat model

Wang

et al. 2019

J. Integr. Neurosci.

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Previous studies showed that brain trauma promotes repair of peripheral nerve injury by reducing scar in nerve endings. The effect of brain injury at different locations on ipsilateral rat sciatic nerve regeneration in Sprague-Dawley rats was found to promote the repair of ipsilateral sciatic nerve injury, thus providing further experimental evidence for the unveiling of traumatic brain injury promoting peripheral nerve regeneration.

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An Experimental Study on Repeated Brief Ischemia in Promoting Sciatic Nerve Repair and Regeneration in Rats

Cited by 6 publications

References 35 publications

Role of Oxygen and Its Radicals in Peripheral Nerve Regeneration: From Hypoxia to Physoxia to Hyperoxia

Role of Oxygen and Its Radicals in Peripheral Nerve Regeneration: From Hypoxia to Physoxia to Hyperoxia

Electrophysiological, biomechanical, and finite element analysis study of sacral nerve injury caused by sacral fracture

Investigation for the correlation between brain injury and injured ipsilateral sciatic nerve regeneration in a rat model

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