An experimental study on the application of “blue” (λ = 450 nm) laser light to remove pigmented skin formations

Podurar, S. A.; Gorbatova, N. Ye.; Bryantsev, A. V.; Zolotov, S. A.; Duvanskiy, V. A.; Tertychny, A. S.; Varev, G. A.

doi:10.37895/2071-8004-2023-27-3-21-35

Lazernaâ medicina

2024

DOI: 10.37895/2071-8004-2023-27-3-21-35

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An experimental study on the application of “blue” (λ = 450 nm) laser light to remove pigmented skin formations

S. A. Podurar,

N. Ye. Gorbatova,

A. V. Bryantsev

et al.

Abstract: Objective. Pigment benign skin formations, including pigment spots, nevi and congenital giant pigment nevi (CGPN) are pathological skin formations located in its various layers, consisting of a cluster of melanocytes – cells containing the pigment melanin. CGPN are a special psychological and medical problem associated with extensive unaesthetic changes in the skin and with changed appearance of the patient Currently, there are numerous methods for treating pigmented skin formations, including CGPN. But all th… Show more

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2024

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Cited by 2 publications

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Optimization of curative techniques with laser light in congenital giant pigmented nevi in children

Podurar,

Gorbatova,

Bryantsev

et al. 2024

Russian Journal of Pediatric Surgery

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Relevance. Congenital giant pigmented nevi (CGPN) occur in 1:20,000 to 1:500,000 newborns, they emit a small (1.5 to 5.0 sq. cm), medium (5.0 to 50.0 sq. cm) and a truly gigantic shape (more than 50.0 sq.cm). CGPN create a psychological problem in children, due to aesthetic discomfort. Various methods of removal are not always effective and are accompanied by complications: relapse (6% - 41%), scarring of the skin (6%), malignancy is possible in adults (10%). The question of effective removal of CGPN remains open. This dictates the need to optimize the methods of treatment with laser radiation of CGPN in children. Previously, individual researchers used infrared radiation (λ) of 10.6 microns of a pulsed periodic CO2 laser for this purpose, and experimental work has also appeared on the use of "blue" (λ) 450 nm laser radiation. The experimental studies performed on the skin of laboratory animals have determined the features of exposure and promising modes of these laser radiation for surgical applications in the removal of CGPN. Goal. Improving the results of treatment of various forms of CGPN in children by using optimized methods of laser radiation treatment. Material and methods. The layered removal of the CGPN was carried out with "blue" laser radiation (λ) 450 nm on the Lasermed 10-03 apparatus, Russian Engineering Club LLC (Tula) and laser radiation (λ) 10.6 microns, pulsed periodic CO2 laser apparatus "ALDAN" (IOF RAS, Moscow). At the CRIEPST Research Institute, treatment of various forms of CGPN was performed for 35 children: 18 patients with a small form, 11 children with an average form, and 6 with a truly gigantic form. The age of the children ranged from 6 years old to 18 years old. The localization of CGPN in 13 children was on the face, in 6 on the anterior surface of the chest, in 8 children on the lower and upper extremities, in 4 patients on the abdominal wall and in 4 in the back area. Results. The final good clinical and aesthetic result was noted in 29 children with small and medium forms of CGPN, preliminary, at the treatment stage, a good clinical and satisfactory aesthetic result in 6 patients with a truly gigantic form, a bad result was not noted. Conclusion. The experience of using optimized methods of treatment using the specified laser radiation has confirmed their clinical and aesthetic effectiveness in removing various forms of CGPN in children and has determined the prospect of their use in pediatric surgery.

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Optimization of curative techniques with laser light in congenital giant pigmented nevi in children

Podurar,

Gorbatova,

Bryantsev

et al. 2024

Russian Journal of Pediatric Surgery

View full text Add to dashboard Cite

show abstract

Effects of “blue” (λ = 450 nm) and pulsed periodic CO2 (λ = 10.6 μm) laser light at the skin of laboratory animals. A comparative experimental study

Podurar,

Gorbatova,

Bryantsev

et al. 2024

Lazernaâ medicina

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Background. Currently, the problem of radical removal of pigmented skin formations with good clinical and aesthetic results remains open. These formations, including congenital giant pigmented nevi (CGPN), are found at birth in 2 % of newborns; acquired nevi are registered in 75 % of children. They can be large in size and quite often are located on visible parts of the body, creating psychological problems in children and leading to aesthetic discomfort. In adulthood, various complications may develop including malignancy which may develop in 10% of patients. Management of pigmented skin formations causes both medical and psychological problems. So, it is reasonable to solve them in childhood. Modern various techniques for the removal of pigmented nevi are not always effective; besides, they are often followed by various complications, like relapses (in 6–41 %) and skin scarring (in 6 %). Such a situation requires development of new highly effective techniques for removing various pigmented nevi, including laser light. Recently, separate works on the application of “blue” (λ = 450 nm) laser light and infrared (λ = 10.6 μm) laser light generated by periodic CO2 laser for the discussed pathology have appeared.Purpose. To conduct a comparative experimental study on the effects of “blue” (λ = 450 nm) laser light and infrared (λ = 10.6 μm) laser light generated by pulsed periodic CO2 laser at the skin of laboratory rats in order to find out promising parameters for surgical removal of pigmented skin formations.Material and methods. Laser devices “Lasermed 10-03” (LLC RIK, Russia) generating in “blue” (λ = 450 nm) and pulsed periodic CO2 laser “ALDAN” (IOF RAS, Russia) generating in infrared (λ = 10.6 μm) laser light were used. In present in vivo experiment, pigmented skin of laboratory rats was exposed to laser light. Exposure zones were compared; features and regeneration terms were analyzed too.Results. The researchers registered specific effects in skin irradiation with laser light as well as in terms of wound regeneration. They also identified optimal parameters of “blue” (λ = 450 nm) and infrared (λ = 10.6 μm) laser light for the removal of CGPN and pigmented skin formations.Conclusion. The obtained results of the present comparative experimental trial have outlined prospects for the application of “blue” (λ = 450 nm) laser light and infrared laser light (λ = 10.6 μm) generated by pulsed periodic CO2 laser for surgical removal of pigmented skin formations.

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An experimental study on the application of “blue” (λ = 450 nm) laser light to remove pigmented skin formations

Cited by 2 publications

References 13 publications

Optimization of curative techniques with laser light in congenital giant pigmented nevi in children

Optimization of curative techniques with laser light in congenital giant pigmented nevi in children

Effects of “blue” (λ = 450 nm) and pulsed periodic CO2 (λ = 10.6 μm) laser light at the skin of laboratory animals. A comparative experimental study

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