Experimental and numerical research on axially compressed columns made from built-up two-chord concrete-filled steel tubes (TCCFSTs) is presented in this study. The columns were constructed from two parallel circular high-strength steel tubes connected by five batten tubes. The chord tubes were filled with high-strength concrete. The yield stress of the steel used was 600 MPa, while the cylinder compressive strength of the concrete was 95 MPa. Hollow specimens were also tested to serve as a control group. An experimental analysis investigated the influence of the compressive strength of the concrete fill on the load-bearing capacity of the column and the influence of the concrete fill on the slenderness of the column. The behavior under load, stress and strain development, and the failure modes of the specimens were also analyzed. The results of the tests showed that all parts of the built-up column participated in the load-bearing process. The load-bearing capacity of the hollow two-chord columns was improved by around 1.74 times, and the slenderness increased by 16% with the concrete infill. The columns filled with concrete exhibited almost linear behavior with a higher ultimate strength and stiffness than the hollow built-up steel columns. Furthermore, the application of three calculation codes to forecast the capacity of the TCCFST columns was evaluated. Additionally, finite element method (FEM) modeling was used to investigate the stresses, strains, deformations, and ultimate capacity of the TCCFST column models loaded with axial compressive force. The FEM model showed good predictions of strength, stresses, deformations, and buckling.