An Experimental Study to Replace the Thoracic Descending Aorta for Pigs with a Self-Made Sutureless Blood Vessel

Song, Fenglin; Zhou, Wenwu; Tang, Tao; Li, Xiaobing; Wu, Xiaoming; Yang, Jinfu

doi:10.1155/2014/587393

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…To address these limitations, researchers have turned to hybrid materials that incorporate polymers and metals. By leveraging the flexibility of polymers along with the rigidity of metals, these hybrid materials offer promising in vivo performance and adaptability to a variety of applications through tailored property tuning [61,62]. Mahdis Shayan et al produced and transplanted small-diameter blood vessels using Nitinol.…”

Section: Biocompatible Materials For 3d-printed Vascular Structuresmentioning

confidence: 99%

“…The PLGA, which is a combination of PGA and PLA, offers the advantage of biocompatibility, high degradability, and tunable physical properties, making it versatile in medical applications. However, the resultant acidic degradation byproducts could influence the local tissue pH, and PLGA's inherent hydrophobicity could impede optimal cell interactions [55][56][57][58][59][60][61][62][63]. Polydioxanone is appropriated by its flexibility and gradual degradation, making it suitable for dynamic tis-sue-engineering applications.…”

Section: Exploring Biodegradable Polymer Selection For Enhanced 3d-pr...mentioning

confidence: 99%

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Development of Biocompatible 3D-Printed Artificial Blood Vessels through Multidimensional Approaches

Choi,

Lee,

Jang

et al. 2023

JFB

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Within the human body, the intricate network of blood vessels plays a pivotal role in transporting nutrients and oxygen and maintaining homeostasis. Bioprinting is an innovative technology with the potential to revolutionize this field by constructing complex multicellular structures. This technique offers the advantage of depositing individual cells, growth factors, and biochemical signals, thereby facilitating the growth of functional blood vessels. Despite the challenges in fabricating vascularized constructs, bioprinting has emerged as an advance in organ engineering. The continuous evolution of bioprinting technology and biomaterial knowledge provides an avenue to overcome the hurdles associated with vascularized tissue fabrication. This article provides an overview of the biofabrication process used to create vascular and vascularized constructs. It delves into the various techniques used in vascular engineering, including extrusion-, droplet-, and laser-based bioprinting methods. Integrating these techniques offers the prospect of crafting artificial blood vessels with remarkable precision and functionality. Therefore, the potential impact of bioprinting in vascular engineering is significant. With technological advances, it holds promise in revolutionizing organ transplantation, tissue engineering, and regenerative medicine. By mimicking the natural complexity of blood vessels, bioprinting brings us one step closer to engineering organs with functional vasculature, ushering in a new era of medical advancement.

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Section: Biocompatible Materials For 3d-printed Vascular Structuresmentioning

confidence: 99%

Section: Exploring Biodegradable Polymer Selection For Enhanced 3d-pr...mentioning

confidence: 99%

Development of Biocompatible 3D-Printed Artificial Blood Vessels through Multidimensional Approaches

Choi,

Lee,

Jang

et al. 2023

JFB

View full text Add to dashboard Cite

show abstract

Experimental Devices Versus Hand-Sewn Anastomosis of the Aorta: A Systematic Review and Meta-Analysis

Manolesou

Georgiopoulos

Lazaris

et al. 2021

Journal of Surgical Research

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Α systematic review and meta-analysis of the efficacy of aortic anastomotic devices

Manolesou

Papaioannou

Georgiopoulos

et al. 2019

Journal of Vascular Surgery

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Objective: One of the factors contributing to complications related to open repair of the aorta is the construction of a hand-sewn anastomosis. Aortic anastomotic devices (AADs), such as the intraluminal ringed graft (IRG), and the anastomotic stenting technique have been developed to perform a sutureless and less complicated anastomosis. This study performed a systematic review and meta-analysis of the literature reporting clinical use of AADs and aimed to assess, primarily, the effect of each device on 30-day overall and operation-related mortality and aortic cross-clamping time and, secondarily, the rate of successful two-sided application of the IRG device and the operation-related morbidity for each device.Methods: An electronic search was performed using MEDLINE, Scopus, ScienceDirect, and Cochrane Library by two independent authors. Our exclusion criteria included studies incorporating fewer than three patients and studies reporting results solely from animals or in vitro testing, results solely from end-to-side anastomosis, and results solely from endarterectomy procedures. The last search date was February 1, 2018.Results: A total of 41 studies were identified that reported outcomes for the use of three different device types: IRG, anastomotic stenting technique, and surgical staplers. The last two types were classified together as the non-IRG group. The meta-analysis included 27 studies with 50 cohorts incorporating 1260 patients. The median age of the incorporated patients was 61.4 years (range, 51-73 years), and 68.9% were male. The operations were performed for the treatment of acute aortic dissection in 82.3%. The pooled overall 30-day mortality rate varied by device type; IRG devices had a mean rate of all-cause mortality of 9.71%, whereas non-IRG devices were associated with a significantly (I 2 ¼ 15.78%; P for Cochrane Q test < .19) lower rate of death (1.47%). The pooled mean aortic cross-clamping time was 35.83 minutes. Metaregression showed that the performance of two-sided anastomosis with the IRG device significantly decreased the aortic cross-clamping time. However, a successful two-sided ringed anastomosis was performed in approximately half of the cases.Conclusions: Taking into account that the majority of operations were performed for the treatment of acute aortic dissection, AADs had a relatively low rate of 30-day mortality. Despite the observed heterogeneity in study protocols and the small sample size in the non-IRG group, the non-IRG group presented with the lowest 30-day mortality rate. Specific device-related complications between the different device types need further investigation.

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An Experimental Study to Replace the Thoracic Descending Aorta for Pigs with a Self-Made Sutureless Blood Vessel

Cited by 4 publications

References 13 publications

Development of Biocompatible 3D-Printed Artificial Blood Vessels through Multidimensional Approaches

Development of Biocompatible 3D-Printed Artificial Blood Vessels through Multidimensional Approaches

Experimental Devices Versus Hand-Sewn Anastomosis of the Aorta: A Systematic Review and Meta-Analysis

Α systematic review and meta-analysis of the efficacy of aortic anastomotic devices

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