An Exploration of the Neural Network of Lance-Adams Syndrome: a Case Report

Song, Jimin; Kang, Wonil; Ohn, Suk Hoon; Jung, Kwang‐Ik; Bashir, Shahid; Yoo, Woo‐Kyoung

doi:10.12786/bn.2021.14.e1

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…Diffusion sensitizing gradients were applied in 64 noncollinear directions with a b-value of 1000 ms/mm 2 . The b = 0 images were scanned before acquisition of the diffusion-weighted images, with 65 volumes in total [ 22 , 23 ].…”

Section: Methodsmentioning

confidence: 99%

Alteration of White Matter in Patients with Central Post-Stroke Pain

Park

Hong

Park

et al. 2021

JPM

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A stroke may be followed by central post-stroke pain (CPSP), which is characterized by chronic neuropathic pain. The exact mechanism has not yet been fully uncovered. We investigated alterations in the white matters in patients with CPSP, compared with stroke patients without CPSP and normal controls. Our retrospective cross-sectional, case-control study participants were assigned to three groups: CPSP (stroke patients with CPSP (n = 17)); stroke control (stroke patients without CPSP (n = 26)); and normal control (normal subjects (n = 34)). The investigation of white matter for CPSP was focused on the values of fiber numbers (FN) and fractional anisotrophy (FA) for spinothalamic tract (STT), anterior thalamic radiation (ATR), superior thalamic radiation (STR) and posterior thalamic radiation (PTR), and corticospinal tract (CST) was measured. The FA for the STT and STR of the CPSP group were lower than those for the stroke control and normal control groups. The FA of CST and ATR did not differ between the CPSP and stroke groups, but both differed from the normal control. The FA of PTR in the stroke control group differed from the normal control group, but not from the CPSP group. The FN of CST, STT, ATR, and STR for the CPSP and stroke control groups did not differ from each other, but both differed from those of normal controls. FN of PTR did not differ between the CPSP and normal control groups. The alterations in the spinothalamic tract and superior thalamic radiation after stroke would play a role in the pathogenesis of CPSP.

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Section: Methodsmentioning

confidence: 99%

Alteration of White Matter in Patients with Central Post-Stroke Pain

Park

Hong

Park

et al. 2021

JPM

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Multimodal Assessment of the Origin of Myoclonus in Lance-Adams Syndrome

Vellieux,

Apartis,

Baudin

et al. 2024

Neurology

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Background and ObjectivesLance-Adams syndrome (LAS), or chronic posthypoxic myoclonus, is a long-term disabling neurologic disorder occurring in survivors of anoxia. The cortical or subcortical origin of this myoclonus is unclear. We aimed to identify the neuroanatomical origin of myoclonus in LAS. MethodsWe conducted a cross-sectional study and investigated patients diagnosed with LAS from the Department of Neurology of Pitié-Salpêtrière Hospital, using multimodal neurologic explorations: EEG with quantitative analyses, polygraphic EMG recording of myoclonus, coupled EEG-EMG analyses with jerk-locked back averaging, and 18 fluorodeoxyglucose PET/CT imaging. ResultsAll 18 patients had action multifocal or generalized myoclonus. Eleven patients also presented seizures, mainly generalized tonic-clonic seizures. For 8 patients, myoclonus decreased after seizures for a variable duration, from 1 day to 2 weeks. Epileptiform discharges were identified over the central median region (n = 14), with a maximal amplitude on the Cz (65 ± 20 μV, n = 12) and Fz (107 μV, n = 1) electrodes, and a significantly increased frequency during non-rapid eye movement sleep stages 1 (12 ± 8.5 events/minute, p = 0.004, n = 9) and 2 (11 ± 8.8 events/ minute, p = 0.016, n = 7) compared with wake (5.5 ± 5.4 events/minute). The duration of the cortical and muscular events was significantly and positively correlated (ρ = 0.58, p < 0.001, n = 9). Action myoclonic jerks with a duration of <50 ms were confirmed in all patients, with a fastdescending corticospinal way organization with a mean biceps brachii-first interossei dorsalis delay of 9.8 ± 1 ms (n = 8). A central cortical transient preceding the muscular jerks was identified (n = 14), with a mean latency of −31.9 ± 2.9 ms for the tibialis anterior muscle (n = 7). A regional metabolism decrease was observed in the precentral cortex, supplementary motor area, paracentral lobule (n = 6), and postcentral cortex and precuneus (n = 5). This metabolism decrease was bilateral in the precentral cortex for 83% of the patients and in the postcentral cortex for 100%. Hypometabolism in the precentral, supplementary motor, and postcentral areas was confirmed with a voxelwise analysis (p < 10 −3 , n = 6). DiscussionOur findings, based on a large cohort of patients with LAS, strongly suggest a cortical myoclonus, originating within the motor cortex and related to epileptiform mechanisms.

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An Exploration of the Neural Network of Lance-Adams Syndrome: a Case Report

Cited by 2 publications

References 20 publications

Alteration of White Matter in Patients with Central Post-Stroke Pain

Alteration of White Matter in Patients with Central Post-Stroke Pain

Multimodal Assessment of the Origin of Myoclonus in Lance-Adams Syndrome

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