An Exploration of the Protective Effects of Investigators’ Ethical Awareness upon Subjects of Drug Clinical Trials in China

Zhang, L.; Huang, Xu; Chen, H. F.

doi:10.1007/s11673-017-9826-5

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Consequently, the demand for clinical trial resources, such as subjects, has witnessed a substantial annual upsurge. The quantity of registered clinical trials in China approached nearly 10,000 ( 2 ), yielding an impressive output value of 700 billion US dollars from 2016 to 2020. According to data from Informa Pharma Intelligence, the average annual growth rate for Phase I to Phase IV clinical trials stood at 20% ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

An online survey on public awareness of drug clinical trials in inland cities of northern China

Wang,

Zhang,

Liu

et al. 2024

Front. Public Health

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ObjectiveThe aims of this survey were to investigate the public awareness of drug clinical trials (DCTs) and willingness to participate the DCTs, and provide references for propaganda and science popularization of DCTs.MethodsA self-designed questionnaire named “an online survey questionnaire on public awareness of DCTs” was used to conduct an online survey from January to March 2022. The demographic characteristics and the response of participants to the awareness and willingness to participate the DCTs were collected. The factors affecting the public awareness of DCTs were analyzed by single factor and binary logistic regression analysis.ResultsOne thousand three hundred eighty valid questionnaires were collected, and the respondents’ awareness rate of DCTs was 61.1%. Thirteen demographic characteristics including age, gender, education, occupation, work fields, household type, marital status, city type, income, medical insurance, medical expenditure, pressure to seek medical care, financial pressure, both significantly affected the qualified rate of participants’ awareness of DCTs (p < 0.001) by single factor analysis. Binary logistic regression analysis indicated that education level, work fields, city type, medical insurance, and medical expenditure affected independently the participants’ awareness rate of DCTs (p < 0.001). 52.9% of the participants were willing to take part in DCTs. “to promote medical progress” (54.4%) or “believe doctors” (31.1%) were the most frequent reasons for subjects participating in DCTs.ConclusionThe public awareness rate of DCTs and the willingness to participate in drug clinical were significantly affected by the demographic characteristics of subjects. Thus, targeting the needs of the public, propaganda, and science popularization of DCTs should be carried out and served public health.

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Section: Introductionmentioning

confidence: 99%

An online survey on public awareness of drug clinical trials in inland cities of northern China

Wang,

Zhang,

Liu

et al. 2024

Front. Public Health

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“…A number of authors consider the ethical responsibilities that health professionals may have as a result of knowledge, be it knowledge that a prescribed drug might be used to end a patient's life (Duckett 2018) or knowledge that a patient will be returned to a harmful environment after discharge (Essex and Isaacs 2018). Other articles discuss the obligation of professionals to have and use knowledge in particular contexts, including the importance of ethical awareness amongst research investigators in China (Zhang, Huang, and Chen 2018) and the need to incorporate ethical and legal knowledge as an integral component of clinical decision-making (Parker et al 2018). The power and limits of information derived from clinical testing and the rights of (potential) parents to use this information is also a common thread.…”

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confidence: 99%

The Power of Knowledge, Responses to Change, and the Gymnastics of Causation

Ashby

Morrell

2018

Bioethical Inquiry

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Inoculating Against Moral Disengagement Creates Ethical Adherence for Narcissism

Jones,

Beekun,

Schermer

et al. 2024

Pers Soc Psychol Bull

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Increasing honesty is critical in modern society. Moral Disengagement Tactics (MDTs) enable individuals to engage in unethical behavior while avoiding self-criticism, making MDTs a form of self-persuasion. One way to prevent persuasion is inoculation. Across three experiments ( N = 972), two preregistered, we randomly assigned individuals to a code of ethics versus inoculation to MDTs condition. Study 1 ( n = 443) found that those high in narcissism reported increased ethical intentions in the inoculation condition. Study 2 ( n = 224) replicated and extended this effect, finding that individuals high in narcissism were more likely to behave honestly in the inoculation condition. Study 3 ( n = 305) was a longitudinal study finding that inoculating those high in narcissism led to fewer lies over the past week’s inoculation. None of these interaction patterns emerged for Machiavellianism or psychopathy. Thus, inoculation to MDTs appears effective in reducing dishonesty among those high in narcissism.

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An Exploration of the Protective Effects of Investigators’ Ethical Awareness upon Subjects of Drug Clinical Trials in China

Cited by 3 publications

References 18 publications

An online survey on public awareness of drug clinical trials in inland cities of northern China

An online survey on public awareness of drug clinical trials in inland cities of northern China

The Power of Knowledge, Responses to Change, and the Gymnastics of Causation

Inoculating Against Moral Disengagement Creates Ethical Adherence for Narcissism

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