No abstract

Up till now, China has not enacted any legal mechanisms governing certification or supervision for ethics committees. This article analyses deficiencies in the protection of subjects in clinical drug trials under China's current laws and regulations; it emphasizes that investigators, as practitioners who have direct contact with subjects, play significant roles in protecting and safeguarding subjects' rights and interests. The paper compares the status quo in China in this area to that of other countries and discusses ways China might enhance the protection of rights and interests of trial subjects, such as enhancing the ethical awareness of investigators through training, improving laws and regulations, and strengthening the communication between investigators and ethics committees.

The purpose of this article was to describe the clinical and microscopic features of a foreign‐body granuloma in submental region that resulted from a fish bone embedded in the floor of mouth. A 45‐year‐old female patient complained of a hard mass in submental region. Clinical examination showed a non‐compressible, firm, fixed lump, painless on palpation. Ultrasound examination showed an internally uneven, uncircumscribed, hypoechoic mass with a steaky hyperechoic spot of 1.1 cm length in the center. A microscopic examination showed newly‐formed granuloma, composed of lympocytes and epithelioid cells, and some microabscess with neurophiles. The final diagnosis was a foreign‐body granuloma with fish bone. Even though foreign‐body granulomas in submental region are rare lesions, surgeon should be familiar with their features and include them in the differential diagnosis of tissue masses.