An Exploratory Multi-reader, Multi-case Study Comparing Transmission Ultrasound to Mammography on Recall Rates and Detection Rates for Breast Cancer Lesions

Malik, Bilal; Iuanow, Elaine; Klock, John C.

doi:10.1016/j.acra.2020.11.011

Cited by 12 publications

(6 citation statements)

References 38 publications

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“…Digital breast tomosynthesis (DBT) was developed to reduce the issues cause by superimposed breast tissue observed in conventional mammography, however, some of the recent studies have shown that DBT does not improve the sensitivity for detecting cancers in women with dense breasts [70] . To this end, we recently performed a multi-reader multi-case (MRMC) study that compared the performance of QT imaging and full-field digital mammography (FFDM) for breast cancer detection [27] and improved area under the curve.…”

Section: Resultsmentioning

confidence: 99%

“…A careful discussion of the comparison between full-field digital mammography (FFDM) and low frequency transmitted ultrasound breast imaging [71] showed the AUC of the ROC improved by 10% and other metrics indicated the viability for the QT images for breast screening in call-back decision.…”

Section: Discussionmentioning

confidence: 99%

“…digital breast tomosynthesis – none of these improvements are isotropic and are thus unable to achieve similar spatial resolution in all imaging planes. The 21 st century has witnessed great progress in imaging modalities [6] , [7] , [8] , [9] , [10] , including ultrasound [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] and in particular 3D model based low frequency ultrasound tomography (3D UT) [1] , [12] , [28] , [29] , [30] , [31] which may be called ‘ volography ’ for reasons explained below. 3D UT or volography (3D ultrasound tomography with full 3D, not 2D, wave propagation modelling) is model based and nearly isotropic in 3D, with higher resolution in the plane of acquisition [32] .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Low frequency 3D transmission ultrasound tomography: technical details and clinical implications

Wiskin

Malik

Klock

2023

Zeitschrift für Medizinische Physik

Self Cite

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Low frequency 3D transmission ultrasound tomography: technical details and clinical implications

Wiskin

Malik

Klock

2023

Zeitschrift für Medizinische Physik

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“…Ultrasound Tomography (USCT) is an emerging non-invasive imaging technology, which currently focuses on early breast cancer detection. [1][2][3] By surrounding the breast with up to several thousand ultrasound transducers, transmission and reflectivity can be simultaneously acquired. While transmission images represent quantitative sound speed and attenuation properties of tissue, conventional reflection tomography reconstructs qualitative images proportional to the magnitude of the impedance gradient.…”

Section: Introductionmentioning

confidence: 99%

Reconstruction of tissue scatter characteristics using 3D ultrasound tomography

Hopp,

Maul,

Ebener

et al. 2024

Medical Imaging 2024: Ultrasonic Imaging and Tomography

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Conventional reflectivity imaging with Ultrasound Tomography (USCT) reconstructs qualitative images proportional to the magnitude of the impedance gradient. We propose a method to additionally recover the scatter characteristics for each reconstructed voxel, i.e. whether a reflection is diffuse or specular. This is achieved using a modification of 3D Synthetic Aperture Focusing Technique (SAFT). Our novel approach separates the incoming and outgoing ultrasound intensity in each voxel according to the incident direction and the direction to the receiver. To reduce memory requirements, we propose several strategies for selecting a subset of data or aggregating data to predefined directions. The reconstruction leads to five-dimensional data, from which for each voxel in 3D space, a 2D scatter map can be derived. It can be interpreted as the distribution of energy which has been introduced from a certain direction and which has been reflected into a particular direction. We validated our approach by a simulation based on the Phong reflection model and perform first reconstructions of experimental data. Using the 2D scatter maps it is possible to distinguish specular from diffuse reflections visually. Extracting first-order statistics from the 2D scatter maps for each voxel can be a means to break down the 5D information to 3D for traditional slice-based visualization. The multidimensional data provided by our method may be used in future as a biomarker for diagnosis as e.g. a plain surface of a cyst may reflect the ultrasound differently than a rough surface of a spiculated mass.

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“…Ultrasound Tomography (USCT) is an emerging technology for early breast cancer detection. 2D and 2.5D USCT systems 1,2 have recently been approved for clinical use. At Karlsruhe Institute of Technology we focus on the design and realization of a 3D USCT system with a hemispherical aperture and unfocussed emission and reception in 3D.…”

Section: Introductionmentioning

confidence: 99%

First imaging results with the new generation of the KIT 3D ultrasound tomography device

Hopp

Zapf

Fernandez-Lago

et al. 2023

Medical Imaging 2023: Ultrasonic Imaging and Tomography

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Ultrasound Tomography (USCT) is an emerging technology for early breast cancer detection. At Karlsruhe Institute of Technology we recently realized a new generation of full 3D USCT device with a pseudo-randomly sampled hemispherical aperture. In this paper we summarize first imaging results with phantoms and first volunteer images. Using a gelatin phantom with PVC inclusions we evaluated transmission imaging, which showed a deviation from the ground truth of less than 5 m/s in the sound speed and 0.2 dB/cm in the attenuation for the phantom body and less than 15 m/s and 0.2 dB/cm for an inclusion with a diameter of 2.2 cm. Geometric errors are in average in the range of 0.2 cm. For reflectivity imaging we showed that the point spread function is nearly isotropic and with an average of 0.26 mm close to the theoretical predictions for the current system. While the system is still in final commissioning, the results of the phantom and volunteer imaging are very promising: after further calibration and deeper analysis with phantoms we aim at starting a clinical study.

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An Exploratory Multi-reader, Multi-case Study Comparing Transmission Ultrasound to Mammography on Recall Rates and Detection Rates for Breast Cancer Lesions

Cited by 12 publications

References 38 publications

Low frequency 3D transmission ultrasound tomography: technical details and clinical implications

Low frequency 3D transmission ultrasound tomography: technical details and clinical implications

Reconstruction of tissue scatter characteristics using 3D ultrasound tomography

First imaging results with the new generation of the KIT 3D ultrasound tomography device

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