An exploratory study on TCM syndrome differentiation in preoperative patients with colorectal cancer assisted by laboratory indicators

Wang, Yanan; Zhang, Min; Wang, Dou; Zhang, Zhi-kuan; Qu, Lian-ping; Xu, Jing; Shi, Cai-dong; Gao, Feng

doi:10.1016/j.heliyon.2022.e10207

Cited by 6 publications

(3 citation statements)

References 33 publications

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“…“Miraculous Pivot” mentioned that “The injury of the stomach, the blood overflow in the parenteral, the parenteral cold, the juice foam and blood phase kneading, the combination of condensation cannot be dispersed, and the product into.” Several clinical studies have retrospectively investigated the TCM symptoms of CRC patients and their associated factors. These studies have found that the most common TCM classification of CRC is the syndrome of damp heat accumulation[ 10 - 12 ]. HQD was first mentioned by Zhang Zhongjing in “Treatise on Febrile Diseases.” According to this monograph, HQD could clear away heat and relieve pain and is a classic therapeutic formula for damp heat in Chinese medicine.…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology and molecular docking-based analyses to predict the potential mechanism of Huangqin decoction in treating colorectal cancer

Li¹,

Tang²,

Yan³

et al. 2023

World J Clin Cases

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BACKGROUND To analyze the potential action mechanism of Huangqin decoction (HQD) in colorectal cancer (CRC) treatment on the basis of network pharmacology and molecular docking. AIM To investigate the molecular mechanisms of HQD for CRC treatment by using network pharmacology and molecular docking. METHODS All HQD active ingredients were searched using the Systematic Pharmacology and Traditional Chinese Medicine Systems Pharmacology databases and the Bioinformatics Analysis Tool for Molecular Mechanisms in traditional Chinese medicine. Then, the targets of the active ingredients were screened. The abbreviations of protein targets were obtained from the UniProt database. A “drug–compound–target” network was constructed to screen for some main active ingredients. Some targets related to the therapeutic effect of CRC were obtained from the GeneCards, DisGeNET, Therapeutic Target Database, and Online Mendelian Inheritance in Man databases. The intersection of targets of Chinese herbs and CRC was taken. A Venn diagram was drawn to construct the intersection target interactions network by referring to the STRING database. Topological analysis of the protein interaction network was performed using Cytoscape 3.7.2 software to screen the core HQD targets for CRC. The core targets were imported into the DAVID 6.8 analysis website for gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses and visualization. Finally, molecular docking was performed using AutoDockTool and PyMOL for validation. RESULTS In total, 280 potential drug-active ingredients were present in HQD, including 1474 targets of the drug-active ingredients. The main active ingredients identified were betulin, tetrahydropalmatine, and quercetin. In total, 10249 CRC-related targets and 1014 drug-disease intersecting targets were identified, including 28 core targets of action such as Jun proto-oncogene, AP-1 transcription factor subunit, signal transducer and activator of transcription 3, tumor protein p53, vascular endothelial growth factor, and AKT serine/threonine kinase 1. The gene ontology enrichment functional analysis yielded 503 enrichment results, including 406 biological processes that were mainly related to the positive regulation of both gene expression and transcription and cellular response to hypoxia, etc. In total, 38 cellular components were primarily related to polymer complexes, transcription factor complexes, and platelet alpha granule lumen. Then, 59 molecular functions were closely related to the binding of enzymes, homologous proteins, and transcription factors. The Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis yielded 139 enrichment results, involving epidermal growth factor receptor tyrosine kinase inhibitor resistance and HIF-1 and mitogen-activated protein kinase signaling pathways. CONCLUSION HQD can play a role in CRC treatment thro...

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Section: Discussionmentioning

confidence: 99%

Network pharmacology and molecular docking-based analyses to predict the potential mechanism of Huangqin decoction in treating colorectal cancer

Li¹,

Tang²,

Yan³

et al. 2023

World J Clin Cases

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show abstract

“…If the external evil is more severe than the physical weakness, it is classified as excessive syndrome (ES) according to TCM concepts; if the two are of the same magnitude, it is classified as deficiency and excessive syndrome (DES); and if the physical weakness is more pronounced, it is defined as deficiency syndrome (DS). The early and early-middle stages of CRC often appear as ES or DES, while the late stages are DS ( 50 , 51 ). Under the guidance of these theories, TCM treatments need to be selected according to the different manifestations of different syndrome types in patients, so as to be used correctly ( 52 ).…”

Section: The M6a Key Enzyme In the Development Of Crcmentioning

confidence: 99%

“…High expression of the keratin 19, keratin 18, keratin 8, ELF3 and serpin family E member 1 genes is a potential marker to identify the TCM evidence type in CRC and, high expression of the ELF3 gene in CRC with DES or ES. High expression of mucin 2 and regenerating family member 4 in DES was mainly related to cell growth, as well as the MAPK and cyclic adenosine 3′,5′-monophosphate signaling pathways, while high expression of collagen type I alpha 2 chain and periostin genes in ES was mainly related to angiogenesis and the PI3K/AKT pathway and the caveolae-associated protein 2 and glutathione peroxidase 1 genes were highly expressed in DS and are mainly related to vomiting, platelet catabolism and endocytosis ( 50 , 53 ).…”

Section: The M6a Key Enzyme In the Development Of Crcmentioning

confidence: 99%

Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review)

Shao,

Han,

Huang

et al. 2023

Int J Oncol

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RNA methylation modifications are closely linked to tumor development, migration, invasion and responses to various therapies. Recent studies have shown notable advancements regarding the roles of RNA methylation in tumor immunotherapy, the tumor microenvironment and metabolic reprogramming. However, research on the association between tumor chemoresistance and N6-methyladenosine (m6A) methyltransferases in specific cancer types is still scarce. Colorectal cancer (CRC) is among the most common gastrointestinal cancers worldwide. Conventional chemotherapy remains the predominant treatment modality for CRC and chemotherapy resistance is the primary cause of treatment failure. The expression levels of m6A methyltransferases, including methyltransferase-like 3 (METTL3), METTL14 and METTL16, in CRC tissue samples are associated with patients' clinical outcomes and chemotherapy efficacy. Natural pharmaceutical ingredients, such as quercetin, have the potential to act as METTL3 inhibitors to combat chemotherapy resistance in patients with CRC. The present review discussed the various roles of different types of key RNA methylation enzymes in the development of CRC, focusing on the mechanisms associated with chemotherapy resistance. The progress in the development of certain inhibitors is also listed. The potential of using natural remedies to develop antitumor medications that target m6A methylation is also outlined.

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TCM syndrome differentiation in colorectal cancer patients assisted by differences in gut microbiota: An exploratory study

Ming-bin,

Ya-nan,

Yong-ting

et al. 2023

Heliyon

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An exploratory study on TCM syndrome differentiation in preoperative patients with colorectal cancer assisted by laboratory indicators

Cited by 6 publications

References 33 publications

Network pharmacology and molecular docking-based analyses to predict the potential mechanism of Huangqin decoction in treating colorectal cancer

Network pharmacology and molecular docking-based analyses to predict the potential mechanism of Huangqin decoction in treating colorectal cancer

Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review)

TCM syndrome differentiation in colorectal cancer patients assisted by differences in gut microbiota: An exploratory study

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