An Exploratory Study on the Antimicrobial Activity of Cetirizine Dihydrochloride

Maji, Himangshu Sekhar; Maji, Sushomasri; Bhattacharya, Mrinal

doi:10.4172/pharmaceutical-sciences.1000288

Cited by 11 publications

(6 citation statements)

References 23 publications

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“…In a study by Martins et al (2008), cetirizine was introduced as an antibacterial agent with inhibitory effects against Staphylococcus aureus and Salmonella typhi [19] . Based on experiments conducted by Maji et al (2017), it was found that cetirizine at a concentration of 1000 μg/mL has more inhibitory effects against E. coli isolates [20] , which was lower than that of a wide range of antibiotics, and its effectiveness was evaluated as more effective. In another study, ibuprofenfluconazole combination was shown to be more potent against candidiasis as a fungal infection [21] .…”

Section: Discussionmentioning

confidence: 99%

Study of Antibacterial Activity of Gentamicin-Cetirizine on Uropathogenic Escherichia coli Isolates

Hasani

Fozouni

2021

IEM

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Background: Urinary tract infections (UTIs) cause a wide range of infections in individuals; they are common nosocomial infections that have recently become difficult to treat because of the increased emergence of multidrug-resistant bacteria. The present study aimed to determine and compare the minimum inhibitory concentration of gentamicin alone and in combination with cetirizine against Escherichia coli strains isolated from hospitalized patients with UTI.Materials & Methods: This study was performed on 76 E. coli strains isolated from a total of 103 samples of patients admitted to three hospitals in Gonbad-e Kavus. Kirby Bauer disk diffusion and broth microdilution tests were used to determine antibiotic susceptibility and the minimum inhibitory concentration (MIC) of gentamicin alone and in combination with cetirizine according to CLSI M100-S25 (2015) criteria. Findings: Evaluation of the minimum inhibitory concentration of gentamicin-cetirizine combination against E. coli isolates showed that none were able to grow at a concentration of 8 µg/mL. The concentration of gentamicin in combination with cetirizine, inhibiting 90% of E. coli isolates (MIC 90 ), was 4 μg/mL, which was 16 times lower than that of gentamicin alone (MIC 90 = 64 μg/mL) (p=.02). Conclusion:Gentamicin in combination with cetirizine was found to be more potent in inhibiting E. coli isolates than gentamicin alone. Therefore, the results of this study could provide a clear perspective for dealing with drug-resistant pathogens.

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Section: Discussionmentioning

confidence: 99%

Study of Antibacterial Activity of Gentamicin-Cetirizine on Uropathogenic Escherichia coli Isolates

Hasani

Fozouni

2021

IEM

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“…Cetirizine, when tested for antimicrobial activity against 42 bacterial strains belonging to the Gram-positive and -negative groups, it was proven that a majority of them were inhibited at 200-2000 µg/mL concentration, and a few were also susceptible below 200 µg/mL concentration [36]. The order of sensitivity towards cetitrizine was: Bacillus sp., Vibrio cholera, Staphylococcus aureus, Escherichia coli and Shigella spp.…”

Section: Antihistaminesmentioning

confidence: 99%

“…The order of sensitivity towards cetitrizine was: Bacillus sp., Vibrio cholera, Staphylococcus aureus, Escherichia coli and Shigella spp. [36]. Moreover, cetirizine in vitro is a bactericidal agent for Staphylococcus aureus and Salmonella typhi.…”

Section: Antihistaminesmentioning

confidence: 99%

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Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance

et al. 2020

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In recent years, due to the dramatic increase in and global spread of bacterial resistance to a number of commonly used antibacterial agents, many studies have been directed at investigating drugs whose primary therapeutic purpose is not antimicrobial action. In an era where it is becoming increasingly difficult to find new antimicrobial drugs, it is important to understand these antimicrobial effects and their potential clinical implications. Numerous studies report the antibacterial activity of non-steroidal anti-inflammatory drugs, local anaesthetics, phenothiazines such as chlorpromazine, levomepromazine, promethazine, trifluoperazine, methdilazine and thioridazine, antidepressants, antiplatelets and statins. Several studies have explored a possible protective effect of statins inreducing the morbidity and mortality of many infectious diseases. Various non-antibiotic agents exhibit antimicrobial activity via multiple and different mechanisms of action. Further studies are required in the field to further investigate these antimicrobial properties in different populations. This is of paramount importance in the antimicrobial resistance era, where clinicians have limited therapeutic options to combat problematic infections.

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“…In particular, therapeutic agents not originally designed for antibiotic or chemotherapeutic purposes but that subsequently demonstrated antimicrobial properties are classified under the name of “non-antibiotics” [ 17 ]. Among them, antihistamines [ 18 , 19 , 20 ], tranquilizers [ 21 ], antihypertensives [ 22 ], antipsychotics [ 23 , 24 , 25 , 26 ], and anti-inflammatory agents [ 27 , 28 ] represent classes of drugs that unexpectedly showed antimicrobial effects. In particular, serotonin reuptake inhibitors have been found to be effective.…”

Section: Introductionmentioning

confidence: 99%

Non-Antibiotic Drug Repositioning as an Alternative Antimicrobial Approach

et al. 2022

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The worldwide scenario of antibiotic resistance and the falling number of funds for the development of novel antibiotics have led research efforts toward the study of specific cost-effective strategies aimed at discovering drugs against microbial infections. Among the potential options, drug repositioning, which has already exhibited satisfactory results in other medical fields, came out as the most promising. It consists of finding new uses for previously approved medicines and, over the years, many “repurposed drugs” displayed some encouraging in vitro and in vivo results beyond their initial application. The principal theoretical justification for reusing already existing drugs is that they have known mechanisms of action and manageable side effects. Reuse of old drugs is now considered an interesting approach to overcome the drawbacks of conventional antibiotics. The purpose of this review is to offer the reader a panoramic view of the updated studies concerning the repositioning process of different classes of non-antibiotic drugs in the antimicrobial field. Several research works reported the ability of some non-steroidal anti-inflammatory drugs (NSAIDs), antidepressants, antipsychotics, and statins to counteract the growth of harmful microorganisms, demonstrating an interesting winning mode to fight infectious diseases caused by antimicrobial resistant bacteria.

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An Exploratory Study on the Antimicrobial Activity of Cetirizine Dihydrochloride

Cited by 11 publications

References 23 publications

Study of Antibacterial Activity of Gentamicin-Cetirizine on Uropathogenic Escherichia coli Isolates

Study of Antibacterial Activity of Gentamicin-Cetirizine on Uropathogenic Escherichia coli Isolates

Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance

Non-Antibiotic Drug Repositioning as an Alternative Antimicrobial Approach

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