An exploratory study to investigate the association between age, physical activity, femoral trochlear cartilage thickness and biomarkers of tissue metabolism in adult males

Roberts, Harry M.; Griffith-Mcgeever, Claire; Owen, J. B.; Angell, Lewis; Moore, Jonathan P.; Thom, Jeanette M.

doi:10.1007/s00421-021-04655-y

Cited by 6 publications

(4 citation statements)

References 49 publications

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“…In a cross-sectional study, younger age and physical activity were associated with thicker cartilage thickness. [ 26 ] However, in our study, age and physical activity were not effective on cartilage thickness. This may be explained by the small sample size or by most patients being physically inactive.…”

Section: Discussioncontrasting

confidence: 78%

Ultrasound measurement of femoral cartilage thickness in patients with familial Mediterrean fever and its relation to amyloidosis and other disease characteristics

Gezer¹

2022

Sisli Etfal

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Objectives: This study aimed to determine femoral cartilage thickness (FCT) in patients with familial Mediterranean fever (FMF) and healthy individuals and to assess the relationship of FCT with the development of amyloidosis and clinical features. Methods: Patients diagnosed with FMF according to the Tel-Hashomer criteria and healthy controls were included in the study. FCT of both knees was measured with a 7–12 MHz linear probe in maximum knee flexion. Three midpoint measurements were obtained from each knee: Lateral femoral condyle (LFC), intercondylar area (ICA), and medial femoral condyle (MFC). The patients’ clinic characteristics include disease duration, medications, comorbid conditions, amyloidosis, chronic renal failure (CRF), FMF gene mutation, arthritis, sacroiliitis, PRAS score, and Physical Activity Questionnaire Short Form score were recorded. Results: A total of 46 patients with FMF (36 women) and 20 age-sex-body mass index-matched controls (14 women) were enrolled in this study. The patients and controls’ mean age were 37±12.9 and 37.5±8.6 years, respectively. Amyloidosis occurred in 7 patients (15.2%), CRF in 3 (6.5%), and knee arthritis in 8 (17%). Disease activity was mild in 55.8%, moderate in 20.9%, and severe in 23.23% of the patients. The mean FCT in millimeter values in the FMF and control groups was as follows: On the right side, LFC 1.9±0.5 and 2±0.52, ICA 2.2±0.77 and 2.25±0.97, and MFC 2±0.47 and 2.25±0.72; on the left side, LFC 1.9±0.4 and 2.05±0.55, ICA 2.25±0.87 and 2.25±0.87, and MFC 1.85±0.5 and 2.25±0.6. Patients with FMF had decreased cartilage thickness at the lateral condyle of both knees (p<0.05) and medial condyle of the left knee (p<0.05) compared with controls. FCT measurements were similar in patients with or without arthritis, amyloidosis, and CRF (p>0.05). FCT scores were not different among the disease activity groups (p>0.05). Conclusion: These findings suggest that patients with FMF have decreased FCT compared with controls, and there is no significant relationship between the FCT and amyloidosis and disease activity.

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Section: Discussioncontrasting

confidence: 78%

Ultrasound measurement of femoral cartilage thickness in patients with familial Mediterrean fever and its relation to amyloidosis and other disease characteristics

Gezer¹

2022

Sisli Etfal

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“…The level of sCOMP increases immediately after physical activity and transiently elevated levels have been detected in athletes from different disciplines such as running [ 28 , 41 , 43 , 44 , 45 , 46 , 47 ], cycling [ 44 ], soccer [ 48 , 49 ], walking [ 37 , 50 , 51 , 52 ], resistance training [ 50 ], physical activity [ 53 ], and drop landing (box high 73 cm) [ 28 , 37 ] or jumping exercises [ 47 ]. sCOMP levels seem to slowly reduce until returning to baseline within 30 min from exposure to a physical challenge [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

Molecular Assessment of Healthy Pathological Articular Cartilages in Physically Active People: A Scoping Review

Petrigna

Trovato

Roggio

et al. 2023

IJMS

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Physiological aging triggers a cascade of negative effects on the human body and the human joint is only one of the several compartments affected by this irreversible and natural process. Osteoarthritis and cartilage degeneration can cause pain and disability; therefore, identifying the molecular processes underlying these phenomena and the biomarkers produced during physical activity is of critical importance. In the present review, the main goal was to identify and discuss the articular cartilage biomarkers analyzed in studies in which physical or sports activities were adopted and eventually to propose a standard operating procedure for the assessment. Articles collected from Pubmed, Web of Science, and Scopus were scrutinized to detect reliable cartilage biomarkers. The principal articular cartilage biomarkers detected in these studies were cartilage oligomeric matrix protein, matrix metalloproteinases, interleukins, and carboxy-terminal telopeptide. The articular cartilage biomarkers identified in this scoping review may aid in a better comprehension of where research on the topic is heading and offer a viable instrument for streamlining investigations on cartilage biomarker discovery.

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“…Although increased sCOMP is difficult to interpret consistently for all persons in all circumstances, increased sCOMP is correlated with increased age. 26,44 In addition, increased baseline sCOMP and increased activity-induced changes for sCOMP have been correlated, numerous times, with markers of degenerative joint disease severity and symptoms for various at-risk populations, including the aged. 15,16,24,28,37,39,40 The purpose of this study was to compare acute sCOMP changes after running and swimming, to better understand (1) the effects of different exercise modes on knee articular cartilage and ( 2) what acute increase of sCOMP concentration after physical activity represents.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

Serum Cartilage Oligomeric Matrix Protein Concentration Increases More After Running Than Swimming for Older People

Hay,

Rhoades,

Bangerter

et al. 2023

Sports Health: A Multidisciplinary Approach

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Background: Knee osteoarthritis is common in older people. Serum cartilage oligomeric matrix protein (sCOMP) is a biomarker of knee articular cartilage metabolism. The purpose of this study was 2-fold: to (1) determine acute effects of running and swimming on sCOMP concentration in older people; and (2) investigate relationships between sCOMP concentration change due to running and swimming and measures of knee health in older people. Hypotheses: Running would result in greater increase in sCOMP concentration than swimming, and increase in sCOMP concentration due to running and swimming would associate positively with measures of poor knee health. Study Design: Cross-sectional. Level of Evidence: Level 3. Methods: A total of 20 participants ran 5 km and 19 participants swam 1500 m. sCOMP concentration was measured immediately before, immediately after, and 15, 30, and 60 minutes after running or swimming. sCOMP concentration change due to running and swimming was compared. Correlations between sCOMP concentration change due to running and swimming, and other measures of knee health were evaluated, including the Tegner Activity Scale and Knee injury and Osteoarthritis Outcome Score. Results: sCOMP concentration increased 29% immediately after running, relative to baseline, but only 6% immediately after swimming ( P < 0.01). No significant relationship was observed between acute sCOMP change due to running and swimming, and observed measures of knee health ( P > 0.05). Participants with clinically relevant knee symptoms exhibited greater sCOMP concentration before and after running and swimming ( P = 0.03) and had greater body mass ( P = 0.04). Conclusion: Running results in greater acute articular cartilage metabolism than swimming; however, the chronic effects of this are unclear. Older people with clinically relevant knee symptoms possess greater sCOMP concentration and are heavier, independent of exercise mode and physical activity level. Clinical Relevance: These results describe the effects of exercise (running and swimming) for older physically active persons, with and without knee pain.

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An exploratory study to investigate the association between age, physical activity, femoral trochlear cartilage thickness and biomarkers of tissue metabolism in adult males

Cited by 6 publications

References 49 publications

Ultrasound measurement of femoral cartilage thickness in patients with familial Mediterrean fever and its relation to amyloidosis and other disease characteristics

Ultrasound measurement of femoral cartilage thickness in patients with familial Mediterrean fever and its relation to amyloidosis and other disease characteristics

Molecular Assessment of Healthy Pathological Articular Cartilages in Physically Active People: A Scoping Review

Serum Cartilage Oligomeric Matrix Protein Concentration Increases More After Running Than Swimming for Older People

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