“…The application of a local intervention, such as systemic acupuncture, may also be effective to reduce the sensitization of peripheral nociceptors in chronic pain. In this type of procedure, the insertion and handling of needles cause a sensation called De Qi (numbness, distension, electricity, heat, cold, weight, irradiation) (29) , which leads to a greater participation of low-conduction Aδ and C fibers, simultaneously to the quick conduction of Aβ fibers (30)(31) . A positive correlation has been reported among the numbness sensation, the pain triggered by the De Qi, propagated by these nociceptive fibers, and the efficacy of acupuncture-induced analgesia (32) .…”