Electric systems are getting more complex with time, and primitive protection methods such as traveling wave and impedance-based methods face limitations and shortcomings. This paper incorporates and presents the applications of an adaptive neuro-fuzzy inference system and compares it with a back propagation neural network, self-organizing map, and hybrid method of discrete wavelet with adaptive neuro-fuzzy inference system for fault detections, classification, and localization in transmission lines. These methods, in comparison with primitive methods, could be capable of detecting, identifying, and predicting the location of the faults more accurately. The IEEE 9-bus system is utilized to obtain data from one end of the transmission line to develop an ANFIS-based model. This system is simulated in MATLAB/Simulink for different fault cases at various locations. The three-phase voltage and current at one end of IEEE 9-bus number seven are taken for training. Three ANFIS models are developed for fault detection, classification, and localization and compared with other models. For verification of the models, mean square error, mean absolute error, and regression analysis have been computed and compared for all the models. All four techniques have performed well for fault classification, detection, and location. However, the percentage error for the ANFIS-based fault model is less compared to backpropagation, self-organizing map, and discrete wavelet transform with ANFIS. Therefore, the proposed ANFIS models can be implemented for deploying in real-time-based protection systems.