The shipping industry has been forced to move towards sustainable fuels. Cryogenic gases, such as Liquefied Natural Gas (LNG), can be a viable solution for fuel storage and transportation even for remote areas. Besides, Liquefied Hydrogen (LH2) seems to be another, yet long-term solution, where several studies are directed towards this new opportunity. To address the intensive use of these two fuels, a detailed comparison from a technical, economic and environmental point of view is strongly required. Nevertheless, so far, a full understanding of the complex phenomena characterizing the accidental release of LNG and LH2 in harbour environment has not been assessed. In the current paper, a comparison of the two fuels is presented regarding safety perspective. The hazards and the consequences that will be caused by an accidental release are described considering the specific storage system which can be possibly installed on small ships such as ferries, small cruisers, and small cargos.