An external exposome-wide association study of hypertensive disorders of pregnancy

Hu, Hui; Zhao, Jinying; Savitz, David A.; Prosperi, Mattia; Zheng, Yi; Pearson, Thomas A.

doi:10.1016/j.envint.2020.105797

Cited by 24 publications

(9 citation statements)

References 69 publications

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Section: Introductionmentioning

confidence: 99%

“…More recently, exposome-wide discovery approaches have pioneered the simultaneous assessment of associations between many environmental risk factors and pregnancy and child health outcomes (e.g., blood pressure, lung function, birth weight, obesity, communication impairments). [21][22][23][24][25][26] First early life exposome studies have also made progress in understanding how multiple exposures correlate and co-exist, [27][28][29][30] how multiple exposures vary geographically and temporally, 27,[30][31][32] which social and dietary factors determine parts of the early life exposome, [33][34][35] and how we may explore associations between multiple exposures and child health. [36][37][38][39] Likewise, the first exposome projects have moved forward in the use of high-throughput omics techniques to characterize the internal part of the exposome and to identify biological signatures and pathways that respond to and interact with environmental exposures.…”

Section: Introductionmentioning

confidence: 99%

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Advancing tools for human early lifecourse exposome research and translation (ATHLETE)

Vrijheid¹,

Basagaña²,

González³

et al. 2021

Environmental Epidemiology

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Early life stages are vulnerable to environmental hazards and present important windows of opportunity for lifelong disease prevention. This makes early life a relevant starting point for exposome studies. The Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE) project aims to develop a toolbox of exposome tools and a Europe-wide exposome cohort that will be used to systematically quantify the effects of a wide range of community- and individual-level environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways, longitudinally from early pregnancy through to adolescence. Exposome tool and data development include as follows: (1) a findable, accessible, interoperable, reusable (FAIR) data infrastructure for early life exposome cohort data, including 16 prospective birth cohorts in 11 European countries; (2) targeted and nontargeted approaches to measure a wide range of environmental exposures (urban, chemical, physical, behavioral, social); (3) advanced statistical and toxicological strategies to analyze complex multidimensional exposome data; (4) estimation of associations between the exposome and early organ development, health trajectories, and biological (metagenomic, metabolomic, epigenetic, aging, and stress) pathways; (5) intervention strategies to improve early life urban and chemical exposomes, co-produced with local communities; and (6) child health impacts and associated costs related to the exposome. Data, tools, and results will be assembled in an openly accessible toolbox, which will provide great opportunities for researchers, policymakers, and other stakeholders, beyond the duration of the project. ATHLETE’s results will help to better understand and prevent health damage from environmental exposures and their mixtures from the earliest parts of the life course onward.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Advancing tools for human early lifecourse exposome research and translation (ATHLETE)

Vrijheid¹,

Basagaña²,

González³

et al. 2021

Environmental Epidemiology

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“…Hypertensive disorders in pregnancy (HDP) is a group of diseases that coexist with pregnancy and hypertension [ 1 , 2 , 3 ]. It is one of the most common obstetric complications [ 4 , 5 ]. In order to reduce the occurrence of HDP and adverse maternal and infant outcomes, the disease needs to be effectively predicted as early as possible.…”

Section: Introductionmentioning

confidence: 99%

Prediction of hypertensive disorders in pregnancy based on placental growth factor

Sun

Zhang

et al. 2021

THC

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BACKGROUND: The prediction of hypertensive disorders in pregnancy (HDP) mainly involves various aspects such as maternal characteristics and biomarkers. OBJECTIVE: We aimed to study the effect of the HDP prediction model with or without placental growth factor (PlGF). METHODS: This study used maternal factors and PlGF, and standardized the data uniformly. At 12–20 weeks, the comprehensive comparison of model quality with or without PlGF was conducted by logistic regression. RESULTS: The area under curve and the model accuracy of the model with PlGF were higher than those of the model without PlGF. The accuracy of the model with PlGF was above 90%. CONCLUSIONS: Adding PlGF to the model for predicting HDP improved the accuracy and effectiveness of the model. This study confirmed the predictive performance of PlGF.

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“…2 Recent reports demonstrate that one's zip code may be a more reliable surrogate for predicting disease risk, life expectancy, and response to treatment than one's genetic profile, thereby substantiating that community-level data have a significant health impact. [3][4][5] Maduka et al 1 have taken an excellent first step in investigating the generalizability of findings from the surgery literature to the general population. However, the next logical step is to ensure the inclusion of race and ethnicity and community-level data in the design of future prospective work to more clearly delineate the contribution of structural racism to health disparities.…”

mentioning

confidence: 99%

“…The resultant social deprivation has been shown to impact the microbiome, epigenomic phenomena, and other upstream determinants of health, possibly explaining differences in disease incidence and outcomes . Recent reports demonstrate that one’s zip code may be a more reliable surrogate for predicting disease risk, life expectancy, and response to treatment than one’s genetic profile, thereby substantiating that community-level data have a significant health impact …”

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confidence: 99%

Now Is the Time for a Critical Conversation About the Reporting of Race and Ethnicity

Stewart

2021

JAMA Surg

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Maduka et al highlight the need for consistent reporting of race and ethnicity in surgery literature in their study "The Reporting of Race and Ethnicity in Surgery Literature." 1 The authors reviewed 2485 articles involving human-based studies published in 7 surgery journals in 2019. They found equally low rates of reporting race and ethnicity in journals that stated they follow the ICMJE recommendations and those that did not. The myriad causes for this finding include disproportionate representation in trials and the inability to gather the data from retrospective studies. The authors also identified the "failure to see relevance when compared to 'biologically' based subject demographics such as age or sex" as a contributor to the lack of reporting on race and ethnicity in these articles. 1 This statement supports the need to consider the intersectionality between structural racism and health inequities.Although most agree that race is a social construct with no biological foundation, the role of race in US history is undeniable. The 1526 arrival of the first slaves to the colony of San Miguel de Gualdape (modern-day Georgetown, South Carolina) began a period of unimaginable cruelty that some believe ended with the passage of the 13th, 14th, and 15th amendments to the US Constitution. However, the ensuing de jure residential segregation and unequal access to educational opportunities denied racial and ethnic minority groups the fun-

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An external exposome-wide association study of hypertensive disorders of pregnancy

Cited by 24 publications

References 69 publications

Advancing tools for human early lifecourse exposome research and translation (ATHLETE)

Advancing tools for human early lifecourse exposome research and translation (ATHLETE)

Prediction of hypertensive disorders in pregnancy based on placental growth factor

Now Is the Time for a Critical Conversation About the Reporting of Race and Ethnicity

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