An extraordinary chemical burn injury cause: Buttercup a report of five cases

A case of phytodermatitis due to Ranunculus arvensis used as an herbal remedy

“…Plants of the genus Ranunculus contain the toxic glycoside ranunculin. In case of dermal contact, ranunculin is converted to the irritant protoanemonin, which leads to subepidermal separation and bulla formation, as seen in our patient.…”

“…However, there are a few case reports of phytodermatitis from R. arvensis . In the literature, there are 10 cases to date, including the Turkish literature, and most of them reported as “plant burn.” Like other members of the Ranunculaceae family, R. arvensis was used for rheumatic pain in most of these reported patients. However, in our patient, his use for this plant was interesting, because he had used it for treating the pustulas.…”

Phytocontact dermatitis due to Ranunculus arvensis mimicking burn injury: report of three cases and literature review

“…In case of dermal contact, ranunculin is broken down to protoanemonin, which leads to dermal-epidermal separation and formation of bullous lesions. This clinical condition is called phytodermatitis [4,8,10]. …”

“…Eskitascioglu et al [4] noted in their study that the severity of chemical burns caused by plant poultices depends on the application method and duration. Reviewing the literature, we found that most patients used the plant as a poultice that was applied to the painful extremity and was covered with a cloth for a period ranging from 25 min to 48 h. We assume that this covering method increases the rate of contact and the degree of damage.…”

Three Cases of Burn Injury Due to Topical Ranunculus Use

“…They applied paramedical therapies when they considered they did not benefit from therapies that they received so far; such a tendency is in agreement with the literature data. A literature search revealed case reports of chemical burns as in our patients induced by Ranunculus species used for joint pain in various regions of Turkey [7,8].…”