As the logic capacity of Field-Programmable Gate Arrays (FPGAs) increases, they are being increasingly used to implement large arithmetic-intensive applications, which often contain a large proportion of datapath circuits. Since datapath circuits usually consist of regularly structured components (called bit-slices) which are connected together by regularly structured signals (called buses), it is possible to utilize datapath regularity in order to achieve significant area savings through FPGA architectural innovations. This paper describes such an FPGA routing architecture, called the multi-bit routing architecture, which employs bus-based connections in order to exploit datapath regularity. It is experimentally shown that, comparing to conventional FPGA routing architectures, the multi-bit routing architecture can achieve 14% routing area reduction for implementing datapath circuits, which represents an overall FPGA area savings of 10%. This paper also empirically determines the best values of several important architectural parameters for the new routing architecture including the most area efficient granularity values and the most area efficient proportion of bus-based connections.