2020
DOI: 10.1088/1741-2552/ab947a
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An HFAC block-capable and module-extendable 4-channel stimulator for acute neurophysiology

Abstract: Objective. This paper describes the design, testing and use of a novel multichannel block-capable stimulator for acute neurophysiology experiments to study highly selective neural interfacing techniques. This paper demonstrates the stimulator’s ability to excite and inhibit nerve activity in the rat sciatic nerve model concurrently using monophasic and biphasic nerve stimulation as well as high-frequency alternating current (HFAC). Approach. The proposed stimulator uses a Howland Current Pump circuit as the ma… Show more

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Cited by 9 publications
(9 citation statements)
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“…Further, it is important to ensure that the hardware can generate the intended waveforms without distortion (e.g., attenuation, rounding of squares). Generating KHF waveforms remains a challenge even in laboratory settings FallahRad et al 2019;Rapeaux and Constandinou 2020), and it is necessary to measure output waveforms at the desired frequencies, output loads, and amplitudes. In this study, we rigorously evaluated our stimulators (Supplementary Figure 1) to confirm the validity of our findings.…”
Section: Discussionmentioning
confidence: 99%
“…Further, it is important to ensure that the hardware can generate the intended waveforms without distortion (e.g., attenuation, rounding of squares). Generating KHF waveforms remains a challenge even in laboratory settings FallahRad et al 2019;Rapeaux and Constandinou 2020), and it is necessary to measure output waveforms at the desired frequencies, output loads, and amplitudes. In this study, we rigorously evaluated our stimulators (Supplementary Figure 1) to confirm the validity of our findings.…”
Section: Discussionmentioning
confidence: 99%
“…Stimulation using a monophasic current pulse of 200 µs duration by the PtIr cuff and the two CE variant cuffs resulted in a similar nerve response, indicative of a successful stimulation and consistent with previous work conducted on the same ex vivo set up. [ 69 ] Both CE cuff variants were able to stimulate A fiber activity at a current density similar to that of the commercial PtIr cuff (Figure 6c), suggesting that the fit of the cuff on the nerve was similar for all devices. The cuff seal is mainly impacted by the fit of the cuff around the nerve.…”
Section: Resultsmentioning
confidence: 84%
“…Buffer flows from the bottle to the nerve bath continuously and drains to waste, or alternatively directly back to the bottle itself. This figure was previously published in Rapeaux and Constandinou ( 2020 ).…”
Section: Methodsmentioning
confidence: 75%