An HLA DRw52 Split Defined by Restriction Fragment Length Polymorphism: Population Genetics in Normals and in an HLA DRw52 Associated Autoimmune Disease

Chatila, M; Luyrink, Lorie; McEleney, James; Strominger, Jack L.; Glass, David N.

doi:10.1007/978-3-662-39946-0_169

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…Chatila et al (39) have reported that variants of the DRB3 genes may be associated with PJRA. Our data suggest that a positive association (nonsignificant after 'correction' of p values) exists between DNA fragments associated with DRB3*Ol/ 02/03 (DRw52).…”

Section: Combined Presence Of Hla Class II Dna Fragmentsmentioning

confidence: 99%

DNA polymorphism of HLA class II genes in pauciarticular juvenile rheumatoid arthritis

Morling

Friis²,

Fugger³

et al. 1991

Tissue Antigens

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We investigated the DNA restriction fragment length polymorphism (RFLP) of the major histocompatibility complex (MHC) class II genes: HLA-DRB, -DQA, -DQB, DPA, and -DPB in 54 patients with pauciarticular juvenile rheumatoid arthritis (PJRA) and in healthy Danes. The frequencies of DNA fragments associated with the following HLA class II genes were increased in PJRA when compared to normal controls: DRB1*08 (DRw8) (35.2% vs 10.3%, RR = 4.6, p less than 10(-3), DRB3*01/02/03 (DRw52) (76.3% vs 48.1%, RR 3.5, p less than 10(-3)), DQA1*0401 (41.0% vs 7.4%, RR = 7.9, p less than 10(-3)), DQA1*0501 (55.6% vs 29.7%, RR = 3.0, p less than 10(-2), DQB1*0301 (DQw7) (46.2% vs 17.5%, RR = 4.0; p less than 10(-2)), DPA1*0201 (44.2% vs 7.9%, RR = 8.7, p less than 10(-5)), and DPB1*02 (DPw2) (40.7% vs 7.1%, RR = 8.5, p less than 10(-6)). The frequency of DRB1*11 was not significantly increased. The frequencies of DNA fragments associated with the following HLA class II genes were decreased in PJRA although not statistically significantly so after 'correction' of p values: DRB1*04 (14.8% vs 40.2%, RR = 0.27; p less than 10(-3)), DRB1*07 (0% vs 25.9%, RR = 0.04, p less than 10(-3)), DRB4*0101 (DRw53) (25.9% vs 53.6%, RR = 0.31, p less than 10(-3)), DQA1*0102 (11.6% vs 36.0%, RR = 0.25, p less than 10(-4)), and DQA1*0201 (2.6% vs 34.2%, RR = 0.05, p less than 10(-2)).(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Combined Presence Of Hla Class II Dna Fragmentsmentioning

confidence: 99%

DNA polymorphism of HLA class II genes in pauciarticular juvenile rheumatoid arthritis

Morling

Friis²,

Fugger³

et al. 1991

Tissue Antigens

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“…The association of the DRw52 antigen with infantile spasms contributes to other evidence that im- munologic mechanisms may be involved in this disorder, since different allotypes of class I1 HLA molecules have been highly associated with several different organ-specific autoimmune diseases (e.g., DR3 with systemic lupus erythematosus, DR4 with rheumatoid arthritis) (Tiwari and Terasaki, 1985). Specifically, DRw52 has been associated with the autoimmune disorders juvenile rheumatoid arthritis (Chatila et al, 1987) and multiple sclerosis (Al-Din et al, 1986). The high frequency of the DRw52 antigen in all ethnic infantile spasm populations could represent the presence of a DR region B3 gene polymorphism associated with different DRBl genes in different ethnic pspulations; thus, the DRB3 gene product may act as the immune response gene in this disorder.…”

Section: Discussionmentioning

confidence: 99%

Serologic HLA Typing in Infantile Spasms

et al. 1988

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Serologic HLA typing was performed on 29 patients with infantile spasms and hypsarrhythmic patterns in their electroencephalograms (EEGs). There were no significant increases in the frequencies of HLA-A, B, and C antigens in the infantile spasm group as compared with controls. However, there was a significant increase in the frequency of DRw52 in the infantile spasm patients (90%) as compared with controls (72%) (p less than 0.05). In addition, 3 of 12 white infantile spasm patients demonstrated the complete B18,DR3 (DRw52) haplotype; none of 150 control white subjects showed this haplotype. These findings contribute to evidence that immunological mechanisms may be involved in the pathophysiology of infantile spasms.

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An HLA DRw52 Split Defined by Restriction Fragment Length Polymorphism: Population Genetics in Normals and in an HLA DRw52 Associated Autoimmune Disease

Cited by 2 publications

References 2 publications

DNA polymorphism of HLA class II genes in pauciarticular juvenile rheumatoid arthritis

DNA polymorphism of HLA class II genes in pauciarticular juvenile rheumatoid arthritis

Serologic HLA Typing in Infantile Spasms

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