2020
DOI: 10.1039/d0lc00131g
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Anin vitrotumor swamp model of heterogeneous cellular and chemotherapeutic landscapes

Abstract: A microfluidic platform was developed that generates a gradient of chemotherapy via diffusion to study evolutionary dynamics of cancer.

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Cited by 12 publications
(13 citation statements)
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References 34 publications
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“…The life cycle of the PACC state has not yet been explored 31 . One characteristic of cells in the PACC state is dormancy 28,29,31,33,35 . Cells in the PACC state exist in a dormant state in terms of cell division and proliferation that prevents cell cycle arrest at mitotic checkpoints from genotoxic stress.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The life cycle of the PACC state has not yet been explored 31 . One characteristic of cells in the PACC state is dormancy 28,29,31,33,35 . Cells in the PACC state exist in a dormant state in terms of cell division and proliferation that prevents cell cycle arrest at mitotic checkpoints from genotoxic stress.…”
Section: Discussionmentioning
confidence: 99%
“…Hyper-abnormal nuclear morphologies, such as multilobulated and multinucleated nuclei, are highly associated with metastasis and recurrence (35,54,65). Since cancer cells in the PACC state exhibit most or all of these distinct nuclear shapes associated with malignancy (54,56,(61)(62)(63) and because recent evidence suggest that the PACC state could be the lynchpin of cancer lethality (23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(35)(36)(37)(38)(39)(40)(41)(42), it is important to investigate the timing and mechanisms utilized by cancer cells to enter and maintain the therapeutic resistant PACC state.…”
mentioning
confidence: 99%
“…In cancer, PACCs may similarly serve as a (reversible) quiescent state that cancer cells can enter when faced with a novel stressor 26 28 . The key role of PACCs under this hypothesis is to allow cancer cells to survive during periods of extreme stress by exiting the cell cycle and protecting their genome 51 , 52 . Once the stressor is removed or conditions otherwise improve, the PACCs can undergo depolyploidization, producing aneuploid progeny that can continue proliferating.…”
Section: Cancer Eco-evolutionary Dynamicsmentioning
confidence: 99%
“…Diversifying bet-hedging in cancer does occur. PACCs have been identified as a small but ever-present fraction of the cancer cell population even in the absence of a major stress such as therapy, nutrient deprivation, or hypoxia (Lin et al, 2020). Cell culture experiments of dormancy show that during serum deprivation, a small proportion of cancer cells remained proliferative.…”
Section: Evolutionary Ecology Of Dormancy Strategiesmentioning
confidence: 99%