An IgM pyroglobulin associated with lymphosarcoma

Patterson, Roy; Roberts, Mary; Rambach, Walter A.; Falleroni, Angelo E.

doi:10.1016/0002-9343(70)90051-3

Cited by 18 publications

(4 citation statements)

References 8 publications

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“…CryoglobuHns are immunoglobulins that form precipitate or gel at reduced temperatures (6,8). Pyroglobulins are immunoglobulins that irreversibly precipitate or gel at elevated temperatures (7,14,(21)(22)(23). Immunoglobulins with both cryo-and pyro-precipitability are very rare.…”

mentioning

confidence: 99%

Chemical and Genetic Characterization of a Monoclonal IgA(λ) Protein with Both Cryo‐ and Pyro‐Precipitability

et al. 1976

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Studies of a monoclonal IgA (lambda) protein with both cryo- and pyro-precipitability show that it belongs to the IgA2 subclass and is positive for the A2m(2) allotypic marker. Like other cryoglobulins, this protein also has an unblocked light chain, and its heavy chain belongs to the VHI subgroup. The first 22 N-terminal amino acids of the lambda chain of this protein showed less than 65% homology with those of other human lambda chains but showed 86% identity with that of an amyloid fibril protein reported by others. The alpha chain of this protein appears to have more glutamic acid or glutamine, or both, and less isoleucine residues than other human alpha chains.

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confidence: 99%

Chemical and Genetic Characterization of a Monoclonal IgA(λ) Protein with Both Cryo‐ and Pyro‐Precipitability

et al. 1976

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“…On the other hand, pyroglobulins of IgM gener ally lose thermoprecipitability when splitted into 7S monomers [14,21].…”

Section: Ultrastructural Studiesmentioning

confidence: 99%

“…Pyroglobulins are M-proteins which pre cipitate irreversibly when heated to 56 °C [8] and are usually found in patients with multiple myeloma and other lymphoproli férative disorders [6,14,22], except for rare cases [9]. Pyroglobulins have been re ported on IgG, IgA and IgM, but not IgD, IgE or Bence-Jones' protein (BJP) [6],…”

Section: Introductionmentioning

confidence: 99%

IgD-Plasma Cell Leukemia Associated with Pyroglobulinemia and Pyroglobulinuria

Tsuda¹,

Kishimoto²

1982

Acta Haematol

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New pyroglobulin variants were found in a patient with a typical plasma cell leukemia. One was found in the urine and proved to be a variant of Bence-Jones’ protein with a molecular weight of approximately 68,000. The other was found in the serum and appears to be the myeloma protein of IgD. Furthermore, an ultrastructural study disclosed myeloma cells in both peripheral blood and bone marrow to have cytoplasmic fibrils which might be unique for plasma cell leukemia.

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“…Because of their irrelevance as to any clinical symptomatology, they are discovered, as a rule, accidentally during the performance of complement fixation tests. With rare exceptions [5], pyro globulinemia is associated with plasma cell myeloma and lymphoproli férative disorders [1,3,9,10,12].We describe here the clinical and serological data of 8 cases of pyro globulinemia, all of which associated with paraproteinemia, detected in our laboratory in the last 3 years. …”

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confidence: 96%

Pyroglobulinemia

Invernizzi¹,

Cattaneo²,

Secondo³

et al. 1973

Acta Haematol

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Of 260 paraproteinemic sera 8 contained pyroglobulins: 1 IgG-myeloma, 1 IgA, 6 Waldenström’s disease, 3 with and 3 without cryoglobulinemia. The clinical and serological findings of these patients are described. Electrophoresis and separation of immunoglobulins suggest that the M-component is the pyroglobulin. In mixed cryoglobulinemias IgM- IgG, only the IgM is the pyroprecipitable component. The thermolability of pyroglobulins is due to a complex mechanism resulting from intramolecular or intermolecular reactions; itis not necessarily linked only to the polymerization at the level of disulfide bonds

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An IgM pyroglobulin associated with lymphosarcoma

Cited by 18 publications

References 8 publications

Chemical and Genetic Characterization of a Monoclonal IgA(λ) Protein with Both Cryo‐ and Pyro‐Precipitability

Chemical and Genetic Characterization of a Monoclonal IgA(λ) Protein with Both Cryo‐ and Pyro‐Precipitability

IgD-Plasma Cell Leukemia Associated with Pyroglobulinemia and Pyroglobulinuria

Pyroglobulinemia

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