Modeling the lifespan of OLED (Organic Light-Emitting Diode) is a complex task as it depends on differentpotentially interacting factors. As the literature on this subject is still scant, new parametric models for calculating the lifespan of OLED are proposed in this work. The Design of Experiment (DoE) methodology is used for cost and accuracy reasons. Different lifespan models based on thermal and electrical experimental aging tests are proposed. As stress factors, current density, temperature and their interactions, which are rarely taken into account in aging studies are simultaneously involved. The analysis of the model parameters highlights the prevalence of temperature compared to current density on the luminance performance of OLEDs. Non-linear models appear as the most accurate.