An imbalance in the production of IL‐1β and IL‐6 by monocytes of bipolar patients: restoration by lithium treatment

Knijff, Esther M.; Breunis, M. Nadine; Kupka, Ralph; Wit, Harm J. de; Ruwhof, Cindy; Akkerhuis, Grard W.; Nolen, Willem A.; Drexhage, Hemmo A.

doi:10.1111/j.1399-5618.2007.00444.x

Cited by 136 publications

(80 citation statements)

References 71 publications

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“…36,37 In addition, mood stabilizers and antidepressants have an anti-inflammatory effect on isolated monocytes. 38,39 In this cross-sectional study, however, we are not able to make causal inferences with respect to pharmacodynamic effects.…”

Section: Discussionmentioning

confidence: 99%

Monocyte and microglial activation in patients with mood-stabilized bipolar disorder

Jakobsson

Bjerke

Sahebi

et al. 2015

jpn

100

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Section: Discussionmentioning

confidence: 99%

Monocyte and microglial activation in patients with mood-stabilized bipolar disorder

Jakobsson

Bjerke

Sahebi

et al. 2015

jpn

100

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“…It also exerts a broad range of effects on immune cells and is reported to inhibit inflammation and apoptosis. It is speculated that this may be one of the mechanisms of action of Lithium since inflammation and aberrant immune responses are often associated with psychiatric diseases (Knijff et al, 2007;Makoukji et al, 2012). LiCl treatment is reported to protect against TNF-α endotoxemia, experimental colitis, type II collagen-induced arthritis, zymosan and ovalbumin-induced asthma.…”

Section: Introductionmentioning

confidence: 99%

Dendritic cells from the elderly display an intrinsic defect in the production of IL-10 in response to Lithium Chloride

Agrawal

Gollapudi

Gupta

et al. 2013

Experimental Gerontology

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Chronic, low grade inflammation is a characteristic of old age. Innate immune system cells such as dendritic cells (DCs) from the elderly display a pro-inflammatory phenotype associated with increased reactivity to self. Lithium is a well-established anti-inflammatory agent used in the treatment of bipolar disorders. It has also been reported to reduce inflammation in DCs. Here, we investigated whether Lithium is effective in reducing the inflammatory responses in DCs from the elderly. The effect of Lithium Chloride (LiCl) was compared on the response of TLR4 agonist, LPS and TLR2 agonist, PAM3CSK4 stimulated aged and young DCs. LiCl enhanced the production of IL-10 in LPS stimulated young DCs. However, it did not affect TNF-α and IL-6 production. In contrast, in aged DCs, LiCl reduced the secretion of TNF-α and IL-6 in LPS stimulated DCs but did not increase IL-10. LiCl had no significant effect on PAM3CSK4 responses in aged and young DCs. LiCl treated DCs also displayed differences at the level of CD4 T cell priming and polarization. LPS-stimulated young DCs reduced IFN-γ secretion and biased the Th cell response towards Th2/Treg while LiCl treated aged DCs only reduced IFN-γ secretion but did not bias the response towards Th2/Treg. In summary, our data suggests that LiCl reduces inflammation in aged and young DCs via different mechanisms. Furthermore, the effect of LiCl is different on LPS and PAM3CSK4 responses.

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“…Chronic inflammation exists in medicated bipolar patients displaying varied correlations with leptin, insulin, soluble TNF receptor-1 (sTNF-R1), and IL-1Ra (11). Notwithstanding, controversy exists as to whether these phenomena are state-dependent (5), normalize in remission (18), or represent trait markers exacerbated by the affective episodes (19). These discrepancies may be explained by heterogeneity in mood state, methodological differences, and not controlling for known confounds, such as obesity (6).…”

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confidence: 99%

Antibody Profiling of Bipolar Disorder Using Escherichia coli Proteome Microarrays

Chen

Syu

Chung

et al. 2015

Molecular & Cellular Proteomics

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To profile plasma antibodies of patients with bipolar disorder (BD), an E. coli proteome microarray comprising ca. 4200 proteins was used to analyze antibody differences between BD patients and mentally healthy controls (HCs). The plasmas of HCs and patients aged 18 -45 years with bipolar I disorder (DSM-IV) in acute mania (BD-A) along with remission (BD-R) were collected. The initial samples consisting of 19 BD-A, 20 BD-R, and 20 HCs were probed with the microarrays. After selecting protein hits that recognized the antibody differences between BD and HC, the proteins were purified to construct BD focus arrays for training diagnosis committees and validation. Additional six BD-A, six BD-R, six HCs, and nine schizophrenic disorder (SZ, as another psychiatric control) samples were individually probed with the BD focus arrays. The trained diagnosis committee in BD-A versus HC combined top six proteins, including rpoA, thrA, flhB, yfcI, ycdU, and ydjL. However, the optimized committees in BD-R versus HC and BD-A versus BD-R were of low accuracy (< 0.6). In the single blind test using another four BD-A, four HC, and four SZ samples, the committee of BD-A versus HC was able to classify BD-A versus HC and SZ with 75% sensitivity and 80% specificity that both HC and SZ were regarded as negative controls. The consensus motif of the six proteins, which form the committee of BD-A versus HC, is [KE]DIL[AG]L[LV]I[NL][IC][SVKH]G[LV][VN][LV] byGapped Local Alignment of Motifs. We demonstrated that the E. coli proteome microarray is capable of screening BD plasma antibody differences and the selected proteins committee was successfully used for BD diagnosis with

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An imbalance in the production of IL‐1β and IL‐6 by monocytes of bipolar patients: restoration by lithium treatment

Abstract: Blood monocytes have an altered proinflammatory status in BD. Lithium treatment restores this altered status. Short-term in vitro exposure of monocytes to lithium has other effects than lithium treatment.

Cited by 136 publications

References 71 publications

Monocyte and microglial activation in patients with mood-stabilized bipolar disorder

Monocyte and microglial activation in patients with mood-stabilized bipolar disorder

Dendritic cells from the elderly display an intrinsic defect in the production of IL-10 in response to Lithium Chloride

Antibody Profiling of Bipolar Disorder Using Escherichia coli Proteome Microarrays

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