AN IMMUNOGLOBULIN IN NEWFOUNDLAND WITH THE GENETIC MARKER Glm(z) WITHOUT Glm(a) IN FIVE SIBLINGS. A POSSIBLE HYBRID MOLECULE

Abstract

SUMMARY Inheritance of Glm(z) without Glm(a) was found in five members of a Newfoundland family. The investigations were suggestive for the transmission of a Gm haplotype (z; n‐; g) coding for Glm(z) and nGlm(a) at the Fd and Fc parts, respectively, of the IgGl heavy chain.

QUANTITATIVE STUDIES OF Gm ALLOTYPES:V. SIMULTANEOUS PRESENCE OF LATENT Gm ALLOTYPES AND DEFICIENT Gm GENES IN A FAMILY WITH HYPOGAMMAGLOBULINAEMIC PROBANDS

“…According to the common and uncommon Gm haplotypes encountered in Caucasian populations (Lefranc et aZ., 1976(Lefranc et aZ., , 1978Natvig et aZ., 1974;Pandey et aZ., 1978;Rivat et af., 1978;Steinberg, 1969;Steinberg et al, 1968Steinberg et al, , 1970Van Loghem & Natvig, 1970;Van Loghem et al, 1976, 1977 three genetic possibilities can account for the present results: I, and her kindred have inherited either a Gm1917;21928 (first hypothesis), or a Gml. 17; J , 2 8 (second hypothesis) or a Gm192*17;21*28 gene (third hypothesis).…”

A CAUCASOID PEDIGREE DEMONSTRATING THE TRANSMISSION OF A Gm1, 2, 17; 5, 13, 14 HAPLOTYPE

“…The haplotypes usually found in Caucasians with the reagents routinely used in this laboratory (reagents to detect G m antigens 1,2,3,17;5,6,13,14 and 21) are Gml. 17;21, Gm'.2*17;21 and Gm3;s713,14. Exceptions to these usual patterns have been reported (Steinberg et al, 1968(Steinberg et al, , 1970van Loghem and Natvig, 1970;van Loghem et al, 1976).…”