An Immunoreactive Peptide of the FSH Involved in Autoimmune Infertility

Gobert, B.; Jolivet-Reynaud, Colette; Dalbon, Pascal; Barbarino-Monnier, P; Fauré, G; Jolivet, Michel; Béné, Marie C.

doi:10.1006/bbrc.2001.6059

Cited by 31 publications

(25 citation statements)

References 30 publications

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“…Out of all antibody isotypes, only anti-FSH IgA correlated with antisperm IgA, suggesting that these antibodies may share the common seminal antigenic origin. In this context, it is supportive to refer to the absence of anti-FSH antibodies in the sera of children (10).…”

Section: Discussionmentioning

confidence: 92%

Circulating anti-follicle-stimulating hormone immunoglobulin A in women: a sperm-prone reaction of mucosal tolerance?

Haller

Sikut

Karro

et al. 2008

Fertility and Sterility

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Section: Discussionmentioning

confidence: 92%

Circulating anti-follicle-stimulating hormone immunoglobulin A in women: a sperm-prone reaction of mucosal tolerance?

Haller

Sikut

Karro

et al. 2008

Fertility and Sterility

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“…Endometriosis and PCOS have been associated with higher values of anti-FSH IgA autoantibodies, and endometriosis also has association with anti-FSH IgG autoantibodies). One of the major epitopes identified was a 78-93 amino acid sequence belonging to part of the human FSH beta-chain (Gobert et al, 2001). This autoantigenic determinant is recognized most frequently by human serum samples from women with AOA.…”

Section: Anti-ovarian Antibodies and Infertilitymentioning

confidence: 99%

Ovarian Biomarkers in Infertility

Vangelov¹,

Dineva²,

Todorova³

et al. 2012

Trends in Immunolabelled and Related Techniques

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“…92 These antibodies bind to various steroid hormone-producing cells 8,14,82,93,94 like adrenal cortex cells, theca cells of ovary, placental syncytiotrophoblast cells, and are known as steroid cell antibodies (StCAs). 82 They also bind to gonadotropins and their receptors, [95][96][97] zona pellucid, 98 oocyte, 99 corpus luteum, 84,100 and can act as markers of ovarian autoimmunity. 82 Furthermore, it was observed that POI has strong association with autoimmune Addison's disease.…”

Section: Autoimmune Factorsmentioning

confidence: 99%

Premature Ovarian Insufficiency: Aetiology and Long-Term Consequences

Kumar¹,

Manesh²

2017

Women Health Open J

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Premature ovarian insufficiency (POI) is characterised by premature cessation of ovulation/ menstruation for 4-6 months along with raised serum gonadotropin levels especially follicle stimulating hormone (FSH) (>40 IU/L) on two or more occasions >4 weeks apart. POI is a heterogeneous disorder resulting from various autoimmune, iatrogenic and metabolic factors, chromosomal or genetic mutations and infections. Premature loss of ovarian function in women with POI is associated with long-term psychosocial sequelae, infertility and major health complications. It is also associated with age-specific increase in mortality due to cardio-vascular diseases. Its occurrence has increased in recent years as more and more women now-a-days attain motherhood late, also there is increase in incidence of gynaecological malignancies and its successful management leading to increased risk of POI. This manuscript aims to highlight the recent advances in pathogenesis and management of POI. Literature regarding premature ovarian insufficiency, its incidence, pathogenesis, management and recent advances was searched from various English language journals, WHO, ACOG data, published peer-reviewed articles on PubMed, Medline, Embase and Google Scholar upto 2017.

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An Immunoreactive Peptide of the FSH Involved in Autoimmune Infertility

Cited by 31 publications

References 30 publications

Circulating anti-follicle-stimulating hormone immunoglobulin A in women: a sperm-prone reaction of mucosal tolerance?

Circulating anti-follicle-stimulating hormone immunoglobulin A in women: a sperm-prone reaction of mucosal tolerance?

Ovarian Biomarkers in Infertility

Premature Ovarian Insufficiency: Aetiology and Long-Term Consequences

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