An impressive case of chromoblastomycosis due to Fonsecaea pedrosoi in a patient with a long history of fungal infection

Romero-Navarrete, Marina; Ruiz, Lydia Fraile; Castillo, Alfredo Guillén del; Arenas, Roberto; Vega‐Memije, María Elisa; Xicohtencatl‐Cortes, Juan; Espinoza-Rivera, M.; Hernández‐Castro, Rigoberto

doi:10.1016/j.mycmed.2018.07.008

Journal de Mycologie Médicale

2018

DOI: 10.1016/j.mycmed.2018.07.008

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An impressive case of chromoblastomycosis due to Fonsecaea pedrosoi in a patient with a long history of fungal infection

Marina Romero-Navarrete

Lydia Fraile Ruiz

Alfredo Guillén del Castillo

et al.

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Cited by 3 publications

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“…(23) The treatment of infections caused by black fungi has always been considered a challenge because there are few therapeutic options and physical treatment methods are usually used together with oral antifungal therapy. (2,24,25) In addition, it is common to associate more than one antifungal drug in the treatment of CBM, in addition to the largely used itraconazole and terbinafine. (26) 5-Fluorocytosine (5FC) and amphotericin B, (27) itraconazole and 5FC, (28) and terbinafine and amphotericin (29) are examples of antifungal combinations used in CBM treatment.…”

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confidence: 99%

New possibilities for chromoblastomycosis and phaeohyphomycosis treatment: identification of two compounds from the MMV Pathogen Box® that present synergism with itraconazole

Coelho

Alves

Figueiredo-Carvalho

et al. 2022

Mem. Inst. Oswaldo Cruz

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BACKGROUND Black fungi of the Herpotrichiellaceae family are agents of chromoblastomycosis and phaeohyphomycosis. There are few therapeutic options for these infections and it is common to associate antifungal drugs in their treatment. OBJECTIVES To investigate the Medicines for Malaria Venture (MMV) Pathogen Box ® for possible compounds presenting synergism with antifungal drugs used to treat black fungal infections. METHODS An initial screening of the Pathogen Box ® compounds was performed in combination with itraconazole or terbinafine at sub-inhibitory concentrations against Fonsecaea pedrosoi . Hits were further tested against eight Herpotrichiellaceae using the checkerboard method. FINDINGS No synergism was observed with terbinafine. MMV687273 (SQ109) and MMV688415 showed synergism with itraconazole against F. pedrosoi . Synergism of these compounds was confirmed with some black fungi by the checkerboard method. SQ109 and itraconazole presented synergism for Exophiala dermatitidis , F. pedrosoi , F. monophora and F. nubica , with fungicidal activity for F. pedrosoi and F. monophora . MMV688415 presented synergism with itraconazole only for F. pedrosoi , with fungicidal activity. The synergic compounds had high selectivity index values when combined with itraconazole. MAIN CONCLUSIONS These compounds in combination, particularly SQ109, are promising candidates to treat Fonsecaea spp. and E. dermatitidis infections, which account for most cases of chromoblastomycosis and phaeohyphomycosis.

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confidence: 99%

New possibilities for chromoblastomycosis and phaeohyphomycosis treatment: identification of two compounds from the MMV Pathogen Box® that present synergism with itraconazole

Coelho

Alves

Figueiredo-Carvalho

et al. 2022

Mem. Inst. Oswaldo Cruz

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Chromoblastomycosis in Latin America and the Caribbean: Epidemiology over the past 50 years

et al. 2021

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Chromoblastomycosis is a chronic disease caused by melanized fungi that mainly affect individuals performing soil-related labour. The objective of this study was to analyse the epidemiological and clinical characteristics of chromoblastomycosis in Latin America and the Caribbean by an extensive literature review. An integrative review was performed of English, French, Portuguese, and Spanish publications in LILACS, SciELO, PubMed, SCOPUS and Web of Science databases covering the period 1969–2019. A total of 1,211 articles were identified, of which 132 were included in the review, covering 2,081 patients, 80.3% were male, the mean age was 56.1 years. The mean duration of the disease was 10.8 years. The lesions were mainly described in the lower limbs (60%). The most frequent clinical forms were verrucous (46.4%) and tumorous (21.7%). Major disease symptoms and signs consisted of itching and pain. Bacterial infection and functional limitation were important complications. Immunosuppression post-kidney transplantation was the most frequent comorbidity while leprosy was the main concomitant infectious disease. Fonsecaea pedrosoi and Cladophialophora carrionii were the predominant etiological agents. Majority of the cured cases were treated with itraconazole as monotherapy or in combination with other antifungals, surgery or cryosurgery. Chromoblastomycosis affects hundreds of rural workers in Latin America and the Caribbean, causing disability and personal, family and economic losses. It is important to prioritize epidemiological surveillance and early diagnosis of this disease in order to reveal its real prevalence and direct resources to preventive actions, diagnosis and early treatment. Lay Summary Chromoblastomycosis is a slowly progressing chronic disease caused by melanized fungi. We collected data from South America and the Caribbean covering 1969-2019, the 132 articles included 2 081 patients, mean disease duration was 10.8 years. Fonsecaea pedrosoi and Cladophialophora carrionii predominated.

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Difficult path to the diagnosis of chromomycosis

Melnikova,

Burtseva,

Cheboksarova

et al. 2024

Vestnik dermatologii i venerologii

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Chromomycosis is a slowly occurring mycosis of subcutaneous adipose tissue and skin. Most often, cases of the disease are recorded in countries with a tropical and subtropical climate. In the Russian Federation, the disease occurs sporadically. Very rarely (2 cases out of 100) malignant transformation into squamous cell carcinoma occurs. The article presents a clinical case of chromomycosis. A description is given of a patient in whom squamous cell carcinoma was detected at the onset of the disease, which was the reason for treatment by oncologists. Six months later, the patient had a relapse in the area of the postoperative scar and a focus in the area of the right hand. Repeated biopsy with histological examination made it possible to establish the correct diagnosis. Interest in the above clinical case was caused by the detection of chromomycosis in a resident of the city of St. Petersburg, who was not in endemic areas, was not engaged in agricultural work, and denied the primary injury. Our patient experienced a rapid malignancy of the focus, after surgical treatment, a recurrence of deep mycosis occurred. A good effect was obtained from systemic antimycotic therapy.

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An impressive case of chromoblastomycosis due to Fonsecaea pedrosoi in a patient with a long history of fungal infection

Cited by 3 publications

References 18 publications

New possibilities for chromoblastomycosis and phaeohyphomycosis treatment: identification of two compounds from the MMV Pathogen Box® that present synergism with itraconazole

New possibilities for chromoblastomycosis and phaeohyphomycosis treatment: identification of two compounds from the MMV Pathogen Box® that present synergism with itraconazole

Chromoblastomycosis in Latin America and the Caribbean: Epidemiology over the past 50 years

Difficult path to the diagnosis of chromomycosis

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