We present new limits on exotic keV-scale physics based on 478 kg d of Majorana Demonstrator commissioning data. Constraints at the 90% confidence level are derived on bosonic dark matter (DM) and solar axion couplings, Pauli exclusion principle violating (PEPV) decay, and electron decay using monoenergetic peak signal-limits above our background. Our most stringent DM constraints are set for 11.8 keV mass particles, limiting gAe < 4.5 × 10 −13 for pseudoscalars and α ′ α < 9.7 × 10 −28 for vectors. We also report a 14.4 keV solar axion coupling limit of g eff AN × gAe < 3.8 × 10 −17 , a 1 2 β 2 < 8.5 × 10 −48 limit on the strength of PEPV electron transitions, and a lower limit on the electron lifetime of τe > 1.2 × 10 24 yr for e − → invisible.PACS numbers: 95.35.+d