An Improved Method for Magnetic Nanocarrier Drug Delivery across the Cell Membrane

Abstract

One of the crucial issues in the pharmacological field is developing new drug delivery systems. The main concern is to develop new methods for improving the drug delivery efficiencies such as low disruptions, precise control of the target of delivery and drug sustainability. Nowadays, there are many various methods for drug delivery systems. Carbon-based nanocarriers are a new efficient tool for translocating drug into the defined area or cells inside the body. These nanocarriers can be functionalized with proteins, peptides and used to transport their freight to cells or defined areas. Since functionalized carbon-based nanocarriers show low toxicity and high biocompatibility, they are used in many nanobiotechnology fields. In this study, different shapes of nanocarrier are investigated, and the suitable magnetic field, which is applied using MRI for the delivery of the nanocarrier, is proposed. In this research, based on the force required to cross the membrane and MD simulations, the optimal magnetic field profile is designed. This optimal magnetic force field is derived from the mathematical model of the system and magnetic particle dynamics inside the nanocarrier. The results of this paper illustrate the effects of the nanocarrier’s shapes on the percentage of success in crossing the membrane and the optimal required magnetic field.

An overview and bibliometric analysis on the colorectal cancer therapy by magnetic functionalized nanoparticles for the responsive and targeted drug delivery

“…The drug delivery through nanoparticles has led researchers worldwide to focus on developing life-saving nanoparticles [ 14 ]. Magnetic nanoparticles (MNPs) based on metals such as iron [ 15 ], nickel [ 16 , 17 ], or metal oxides [ 18 ] have aided modern technology's efficient development [ 19 ]. MNPs can find various biomedical applications, including simultaneously therapy and diagnosis [ 20 ]; hence, the enormous interest in MNPs efficiency can be easily understood [ 21 ].…”

Analysis of Dynamics Targeting CNT-Based Drug Delivery through Lung Cancer Cells: Design, Simulation, and Computational Approach

“…Carbon nanotubes (CNTs) have gained full attention so far in life science applications [ 1 , 2 , 3 , 4 , 5 , 6 ]. These applications include separation [ 1 , 2 , 3 , 7 ], drug delivery [ 8 , 9 , 10 , 11 , 12 ], and hyperthermia by guiding with magnetic nanoparticles [ 13 , 14 , 15 , 16 ].…”

“…Moreover, in the non-invasive delivery method, CNTs can be directed by exerting an external magnetic force. Furthermore, CNTs can be used as a carrier for drug delivery to cancer cells inside the body [ 6 , 17 ]. As CNTs can be functionalized and guided by an external force, they can also be used for targeted drug delivery to the brain [ 18 ].…”

Publication Trends in Drug Delivery and Magnetic Nanoparticles

“…Between various issues in the pharmacological field, developing beneficial drug delivery systems is one of the important key factors [2]. The main concern is focused on improving drug delivery efficiencies which are generally described in low disruptions, sustainability, and accurate and precise targeted delivery control [3].…”

“…Carbon-based nanotubes (CNTs) are a new method of drug translocating into targeted places inside the human body which are functionalised with proteins and peptides. Concerning low toxicity and high biocompatibility of functionalised CNTs, they are widely used in many nanobiotechnology application [3]. Beside the nanocarriers method, some researchers used bare nanoparticles as a novel method for brain disorder detection.…”