“…In addition, SSIM has been repeatedly improved, with several derivative methods developed, such as gradient-based SSIM (GSSIM), three-component weighting region, four-component weighting region, complex wavelet, and an improved SSIM with a sharpness comparison (ISSIM-S) [ 31 , 32 , 33 , 34 , 35 ]. In these advanced implementations, SSIM was transformed to demonstrate reasonable performance in assessing images without a reference and can be used for image decomposition, identifying inter-patch and intra-patch similarities, and deblurring IQA [ 36 , 37 , 38 , 39 ]. SSIM is used widely to evaluate images, including medical images; therefore, this study presents four types of SSIM as a computer-based observer to assess DOT reconstructed images.…”