An in situ formed biodegradable hydrogel for reconstruction of the corneal endothelium

Liang, Ye; Liu, Wanshun; Han, Baoqin; Yang, Cui; Ma, Qun; Song, Fulai; Bi, Qingqing

doi:10.1016/j.colsurfb.2010.07.043

Cited by 97 publications

(83 citation statements)

References 28 publications

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“…It was also found that the grafted HP-chitosan copolymer killed 99.9% of S. aureus and E. coli within 30 min, and had relatively higher superoxide anion scavenging ability owing to the incorporation of hydroxyl groups (Xie et al, 2002b;Sun et al, 2004). In addition, HP-chitosan derivatives have been employed as composite hydrogel for corneal endothelium reconstruction and adhesion scaffold of mesenchymal stem cells in tissue engineering (Gao et al, 2008;Wang et al, 2009;Liang et al, 2011). Recently, more and more experimental results have been reported on the potential applications and exploitations of CM-chitosan and HP-chitosan in absorbable biomaterial field (Ling et al, 2008;Bayramoglu et al, 2011;Riva et al, 2011).…”

Section: Introductionmentioning

confidence: 96%

Pharmacokinetics and biodegradation performance of a hydroxypropyl chitosan derivative

Shao

Han

Dong

et al. 2015

J. Ocean Univ. China

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Hydroxypropyl chitosan (HP-chitosan) has been shown to have promising applications in a wide range of areas due to its biocompatibility, biodegradability and various biological activities, especially in the biomedical and pharmaceutical fields. However, it is not yet known about its pharmacokinetics and biodegradation performance, which are crucial for its clinical applications. In order to lay a foundation for its further applications and exploitations, here we carried out fluorescence intensity and GPC analyses to determine the pharmacokinetics mode of fluorescein isothiocyanate-labeled HP-chitosan (FITC-HP-chitosan) and its biodegradability. The results showed that after intraperitoneal administration at a dose of 10 mg per rat, FITC-HP-chitosan could be absorbed rapidly and distributed to liver, kidney and spleen through blood. It was indicated that FITC-HP-chitosan could be utilized effectively, and 88.47% of the FITC-HP-chitosan could be excreted by urine within 11 days with a molecular weight less than 10 kDa. Moreover, our data indicated that there was an obvious degradation process occurred in liver (< 10 kDa at 24 h). In summary, HP-chitosan has excellent bioavailability and biodegradability, suggesting the potential applications of hydroxypropyl-modified chitosan as materials in drug delivery, tissue engineering and biomedical area.

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Section: Introductionmentioning

confidence: 96%

Pharmacokinetics and biodegradation performance of a hydroxypropyl chitosan derivative

Shao

Han

Dong

et al. 2015

J. Ocean Univ. China

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“…They can be cast into practically any shape, size, or form [4] for different applications such as controlled drug release devices [5][6][7], tissue engineering scaffolds [8] and biosensors [9]. In recent years, stimuli-responsive polymers have been vigorously investigated due to their attractive properties: volume or phase transitions in response to slight environmental changes including temperature [10], pH [11], salt concentration [12] and magnetism [13].…”

Section: Introductionmentioning

confidence: 99%

A novel thermo-responsive hydrogel based on salecan and poly(N-isopropylacrylamide): Synthesis and characterization

Wei

et al. 2015

Colloids and Surfaces B: Biointerfaces

117

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“…The chitosan films demonstrated the ability to support the attachment and proliferation of ovine CECs and also had excellent mechanical, optical, biocompatible properties appropriate for corneal regenerative engineering [126]. Similarly, Liang et al showed that a composite biodegradable hydrogel made of chitosan and sodium alginate can be used as a scaffold for CEC proliferation and are useful for the reconstruction of the corneal endothelium [127]. Grolik et al developed a novel hydrogel scaffold based on a chitosan-collagen blend crosslinked with genipin for culturing corneal epithelial cells [125].…”

Section: Corneal Regenerative Engineeringmentioning

confidence: 96%

Chitosan Hydrogels for Regenerative Engineering

Padmanabhan

Nair

2015

Springer Series on Polymer and Composite Materials

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Research in the field of hydrogels has been actively growing for the past couple of decades. Hydrogels are crosslinked polymers with high water content. They can be prepared from natural, synthetic, and composite polymers using different chemical and physical crosslinking methods. Hydrogels have been widely explored for the delivery of bioactive molecules, drugs, and for other therapeutic applications. Chitosan-based hydrogels have unique advantages owing to their biocompatibility, biodegradability, antimicrobial activity, mucoadhesivity, and low toxicity. This chapter reviews the different methods used for preparing chitosan-based hydrogels and their applications as cell, protein, and drug delivery vehicles to support tissue regeneration.

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An in situ formed biodegradable hydrogel for reconstruction of the corneal endothelium

Cited by 97 publications

References 28 publications

Pharmacokinetics and biodegradation performance of a hydroxypropyl chitosan derivative

Pharmacokinetics and biodegradation performance of a hydroxypropyl chitosan derivative

A novel thermo-responsive hydrogel based on salecan and poly(N-isopropylacrylamide): Synthesis and characterization

Chitosan Hydrogels for Regenerative Engineering

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