An in vitro analysis of the effect of acidosis on coagulation in chronic disease states – a thromboelastograph study

White, Hayden; Bird, Robert; Sosnowski, Kellie; Jones, Mark

doi:10.7861/clinmedicine.16-3-230

Cited by 3 publications

(6 citation statements)

References 25 publications

(27 reference statements)

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“…To exclude an effect of glucose itself on the thrombin generation, we tested standard plasma with increasing glucose levels (50‐500 mg/dL) and found no correlative dependency (data not shown). Neither did we find a correlation with pH‐levels in our experiments which is in line with findings by White et al, who investigated acidosis dependent alterations in thromboelastometry 22 . Hence, these changes hint to either a decrease of inhibitors of thrombin generation or an elevation of procoagulant triggers.…”

Section: Discussionsupporting

confidence: 92%

“…Neither did we find a correlation with pH-levels in our experiments which is in line with findings by White et al, who investigated acidosis dependent alterations in thromboelastometry. 22 Hence, these changes hint to either a decrease of inhibitors of thrombin generation or an elevation of procoagulant triggers.…”

Section: Plasmatic Coagulation and Activation Markersmentioning

confidence: 99%

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Increased tissue factor activity promotes thrombin generation at type 1 diabetes onset in children

et al. 2020

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Objective: In type 1 diabetes (T1D), a prothrombotic status due to elevated coagulation factors coincides with metabolic derailment. In a previous study, we discovered altered thrombin generation profiles in children with T1D. These alterations are potentially most pronounced at T1D onset and ameliorated after insulin treatment. We tested this hypothesis in a longitudinal study, measuring thrombin generation together with coagulation parameters in children at T1D onset and during follow-up. Materials and methods: Twenty-three children (12 female, age: 9.4 [2.7-17.3] years; median [range]) were tested at T1D onset and after long-term insulin treatment. Thrombin generation was measured using calibrated automated thrombography. Tissue factor (TF) activity and tissue factor pathway inhibitor (TFPI) activity were measured using enzyme-linked immunosorbent assay (ELISA). Results: A procoagulant shift was observed in thrombin generation traces at T1D onset compared to follow-up (time to peak

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Section: Discussionsupporting

confidence: 92%

Section: Plasmatic Coagulation and Activation Markersmentioning

confidence: 99%

Increased tissue factor activity promotes thrombin generation at type 1 diabetes onset in children

et al. 2020

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“…Acidosis is known to be an important cause of coagulation dysfunction, but the specific underlying mechanism is still unclear. [ 14 – 16 ] Coagulation is initiated by the activation of coagulation factors, which can transform prothrombin into thrombin and fibrinogen into fibrin, in the presence of thrombin; this is accompanied by platelet activation and the formation of blood clots through adhesion and aggregation with fibrin. Thus, the formation rate and stability of blood clots, which are the final products of the coagulation process, are important factors influencing coagulation.…”

Section: Discussionmentioning

confidence: 99%

CO2 artificial pneumothorax on coagulation and fibrinolysis during thoracoscopic esophagectomy

Ren

Yan

et al. 2021

Medicine

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Background: CO2 artificial pneumothorax creates a sufficient operative field for thoracoscopic esophagectomy. However, it has potential complications and continuous CO2 insufflation may impede coagulation and fibrinolysis. We sought to compare the effects of CO2 artificial pneumothorax on perioperative coagulation and fibrinolysis during thoracoscopic esophagectomy. Methods: We investigated patients who underwent thoracoscopic esophagectomy with (group P, n = 24) or without CO2 artificial pneumothorax (group N, n = 24). The following parameters of coagulation–fibrinolysis function: intraoperative bleeding volume; serum levels of tissue plasminogen activator (t-PA), plasminogen activator inhibitor (PAI-1), thromboelastogram (TEG), D-Dimer; and arterial blood gas levels were compared with two groups. Results: Group P showed higher levels of PaCO2, reaction time (R) value and kinetics (K) value, but significantly lower pH value, alpha (α) angle and Maximum Amplitude (MA) value at 60 minutes after the initiation of CO2 artificial pneumothorax than group N ((P < .05, all). The t-PA level after CO2 insufflation for 60 minutes was significantly higher in group P than in group N (P < .05), but preoperative levels were gradually restored on cessation of CO2 insufflation for 30 min (P > .05). There was no significant difference in D-dimer. Conclusion: CO2 artificial pneumothorax during thoracoscopic esophagectomy had a substantial impact on coagulation and fibrinolysis, inducing significant derangements in pH and PaCO2. Trial registration: The study was registered at the Chinese clinical trial registry (ChiCTR1800019004)

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“…The factors involved in abnormal coagulation in COPD have also been reported. For example, acidosis could affect the coagulation status in COPD patients 8 . Respiratory bacterial infections, lipoprotein‐associated phospholipase A2, myeloperoxidase, and vascular endothelial growth factor could change the coagulation status, which could be the high risk factors of thrombotic events 9 .…”

Section: Introductionmentioning

confidence: 99%

“…For example, acidosis could affect the coagulation status in COPD patients. 8 Respiratory bacterial infections, lipoprotein-associated phospholipase A2, myeloperoxidase, and vascular endothelial growth factor could change the coagulation status, which could be the high risk factors of thrombotic events. 9 However, the factors lead to coagulation dysfunction in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remain insufficient explored.…”

mentioning

confidence: 99%

Coagulation dysfunction in patients with AECOPD and its relation to infection and hypercapnia

Liu

Jiang

et al. 2021

Clinical Laboratory Analysis

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Chronic obstructive pulmonary disease (COPD) is one of the common chronic airway obstructive diseases, characterized by persistent respiratory symptoms and airflow limitation. Chronic respiratory diseases was recognised as the third leading cause of death in 2017 and COPD was the most common cause of chronic respiratory disease-attributable deaths. 1 It is estimated that COPD will become the fourth largest cause of death in the world and potentially the direct cause of 4.4 million deaths. 2 This will place a significant burden on economic and healthcare systems throughout the world. Although the inflammation in the early stage of COPD only involves the trachea and lung, hypoxia and further acute inflammation are systemic. In acute exacerbation stage,

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An in vitro analysis of the effect of acidosis on coagulation in chronic disease states – a thromboelastograph study

Cited by 3 publications

References 25 publications

Increased tissue factor activity promotes thrombin generation at type 1 diabetes onset in children

Increased tissue factor activity promotes thrombin generation at type 1 diabetes onset in children

CO2 artificial pneumothorax on coagulation and fibrinolysis during thoracoscopic esophagectomy

Coagulation dysfunction in patients with AECOPD and its relation to infection and hypercapnia

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