An in vitro investigation on the cytotoxic and nuclear receptor transcriptional activity of the mycotoxins fumonisin B1 and beauvericin

Fernández-Blanco, Celia; Frizzell, Caroline; Shannon, Maeve; Ruiz, María-José; Connolly, Lisa

doi:10.1016/j.toxlet.2016.05.021

Cited by 36 publications

(22 citation statements)

References 45 publications

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“…Different in vitro and in vivo [120,121,122] approaches were suggested in the past to test for changes in toxicity (Table 4), each with a unique set of advantages and challenges [123,124]. The adopted system should take into consideration: (a) the nature of the tested mycotoxin as screening carcinogens for example with long-term exposure studies is different from screening estrogenic toxins; (b) host suitability and selection since mono-gastric animals for example show higher sensitivity towards certain toxins (such as DON) in comparison to other livestock; (c) the solubility and stability of final biotransformation products (the reduced solubility and stability of 3- keto -DON for example necessitates using organic solvents for storing and diluting this metabolite that might interfere with assay outcomes in certain cases.…”

Section: Strategies and Methodologiesmentioning

confidence: 99%

Strategies and Methodologies for Developing Microbial Detoxification Systems to Mitigate Mycotoxins

Zhu

Hassan

Lepp

et al. 2017

Toxins

100

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Mycotoxins, the secondary metabolites of mycotoxigenic fungi, have been found in almost all agricultural commodities worldwide, causing enormous economic losses in livestock production and severe human health problems. Compared to traditional physical adsorption and chemical reactions, interest in biological detoxification methods that are environmentally sound, safe and highly efficient has seen a significant increase in recent years. However, researchers in this field have been facing tremendous unexpected challenges and are eager to find solutions. This review summarizes and assesses the research strategies and methodologies in each phase of the development of microbiological solutions for mycotoxin mitigation. These include screening of functional microbial consortia from natural samples, isolation and identification of single colonies with biotransformation activity, investigation of the physiological characteristics of isolated strains, identification and assessment of the toxicities of biotransformation products, purification of functional enzymes and the application of mycotoxin decontamination to feed/food production. A full understanding and appropriate application of this tool box should be helpful towards the development of novel microbiological solutions on mycotoxin detoxification.

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Section: Strategies and Methodologiesmentioning

confidence: 99%

Strategies and Methodologies for Developing Microbial Detoxification Systems to Mitigate Mycotoxins

Zhu

Hassan

Lepp

et al. 2017

Toxins

100

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“…The decrease in estradiol production was not linked to a significant modification on CYP19A1 expression in bovine granulosa cells, while it was observed in porcine granulosa cells [ 70 ], indicating that another mechanism of action should be implied (i.e., estradiol metabolism and/or FSH/IGF1-receptors). It has been reported that FB1 can modulate the endocrine system by antagonism of nuclear receptor transcriptional activity [ 71 ], but whether this is how FB1 is acting in granulosa cells will require further elucidation. Moreover, many in vitro studies concerning the reproductive effects in cattle have shown that the co-exposure plays a fundamental role, and that doses tested have a strong influence on the entity and type of exerted effects [ 72 , 73 ].…”

Section: Fumonisin Bmentioning

confidence: 99%

Fusarium Molds and Mycotoxins: Potential Species-Specific Effects

Bertero

Moretti

Spicer

et al. 2018

Toxins

129

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This review summarizes the information on biochemical and biological activity of the main Fusarium mycotoxins, focusing on toxicological aspects in terms of species-specific effects. Both in vitro and in vivo studies have centered on the peculiarity of the responses to mycotoxins, demonstrating that toxicokinetics, bioavailability and the mechanisms of action of these substances vary depending on the species involved, but additional studies are needed to better understand the specific responses. The aim of this review is to summarize the toxicological responses of the main species affected by Fusarium mycotoxins.

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“…This type of studies support the theory that crop residues are the source of Fusarium toxin inoculum, so alternating crops would reduce the possibility of contamination. However, studies such as that reported by Fernández-Blanco et al [25] indicate that wheat grown consecutively (each year) has less contamination by Fusarium toxins than alternately grown wheat. Urea fertilization is another strategy to reduce contamination by Fusarium sp.…”

Section: Possible Mechanisms and Management That Modulate Inhibition mentioning

confidence: 89%

“…The exposure levels ranging from 0.02 to 0.2 mg/kg in body weight have been found of fumonisin concentration; these are within the limit of intake. Although fumonisins are relatively thermal stability, these may undergo reactions in food systems that alter their chemical structure and toxicity and is potentially hazardous to the health of both humans and animals [25].…”

Section: Fumonisinsmentioning

confidence: 99%

Fusarium Mycotoxins and Metabolites that Modulate Their Production

Jiménez-García¹,

García-Mier²,

García‐Trejo³

et al. 2018

Fusarium - Plant Diseases, Pathogen Diversity, Genetic Diversity, Resistance and Molecular Markers

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The genus Fusarium is a group of fungi producing several types of toxins with toxicological effect in both humans and animals. Such fungi are commonly found in soils so it can contaminate various types of crops, preferably cereals, leading to significant economic losses. Relative humidity, storage temperature and various handling in cereales increase the possibility of contamination by Fusarium toxins. Cereals naturally have secondary metabolites that may help attenuate contamination by these toxins, but it is necessary to know strategies and mechanisms that generate inactivation mycotoxins. This chapter reviews relevant information about cereal mycotoxin contamination, as well as the production of cereal secondary metabolites as a strategy to reduce the possibility of mycotoxin contamination.

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An in vitro investigation on the cytotoxic and nuclear receptor transcriptional activity of the mycotoxins fumonisin B1 and beauvericin

Cited by 36 publications

References 45 publications

Strategies and Methodologies for Developing Microbial Detoxification Systems to Mitigate Mycotoxins

Strategies and Methodologies for Developing Microbial Detoxification Systems to Mitigate Mycotoxins

Fusarium Molds and Mycotoxins: Potential Species-Specific Effects

Fusarium Mycotoxins and Metabolites that Modulate Their Production

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