An in vitro Study of a Phase-Shift Nanoemulsion: A Potential Nucleation Agent for Bubble-Enhanced HIFU Tumor Ablation

Zhang, Peng; Porter, Tyrone M.

doi:10.1016/j.ultrasmedbio.2010.07.001

Cited by 158 publications

(164 citation statements)

References 82 publications

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“…However, preexisting nucleation sites for cavitation are not omnipresent in most tissues in vivo. Either ultrasound contrast agents (UCA) [16][17][18] or nanoparticles have been studied as methods of delivering nuclei into the target region. 13 The use of UCA and nanoparticles, however, requires the systematic injection of foreign particles into the blood stream and would cause much concern regarding the toxicity, efficiency, etc.…”

Section: -mentioning

confidence: 99%

Enhanced-heating effect during photoacoustic imaging-guided high-intensity focused ultrasound

Cui¹,

Yang²

2011

Applied Physics Letters

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Photoacoustic imaging (PAI) technique has been used to monitor thermal lesion formation during high-intensity focused ultrasound (HIFU) treatment. While previous studies focused on photoacoustic detection of changes in temperature during HIFU treatment, we report an enhanced-heating effect when PAI is used to monitor HIFU treatment. We found that the temperature induced by HIFU could be significantly enhanced when the diagnostic laser system for photoacoustic detection was operating during HIFU treatment. This finding demonstrates an advantage of using PAI to guide HIFU therapy.

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Section: -mentioning

confidence: 99%

Enhanced-heating effect during photoacoustic imaging-guided high-intensity focused ultrasound

Cui¹,

Yang²

2011

Applied Physics Letters

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“…Many research efforts have been made to create nucleation sites for cavitation and reduce cavitation threshold. Both ultrasound contrast agents (UCAs) [13][14][15][16][17][18] and nanoparticles have been studied as methods to deliver cavitation nuclei into the targeted region. 19,20 The use of UCA or nanoparticles, however, requires the systematic injection of foreign particles into the blood stream, and would have major concerns regarding toxicity, efficiency, etc.…”

mentioning

confidence: 99%

Laser-enhanced cavitation during high intensity focused ultrasound: An in vivo study

Cui

Zhang²,

Yang³

2013

Applied Physics Letters

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Laser-enhanced cavitation during high intensity focused ultrasound (HIFU) was studied in vivo using a small animal model. Laser light was employed to illuminate the sample concurrently with HIFU radiation. The resulting cavitation was detected with a passive cavitation detector. The in vivo measurements were made under different combinations of HIFU treatment depths, laser wavelengths, and HIFU durations. The results demonstrated that concurrent light illumination during HIFU has the potential to enhance cavitation effect by reducing cavitation threshold in vivo. High intensity focused ultrasound (HIFU) is a truly noninvasive thermal-ablation technique. HIFU works through rapidly depositing high intensity ultrasound energy into a small region to induce cell death primarily by hyperthermia after high intensity ultrasound is absorbed by soft tissue. [1][2][3][4][5] While the application of HIFU therapy is expanding, one concern related to HIFU treatment is the prolonged treatment time for large tumors because HIFU lesion is relatively small for each HIFU shot.Cavitation has been shown to yield elevated heating rate above those produced by classical acoustic absorption in tissue and can provide an effective method to improve the efficiency of HIFU treatment.6-12 However, pre-existing nucleation sites for cavitation are not omnipresent in most tissues in vivo. Many research efforts have been made to create nucleation sites for cavitation and reduce cavitation threshold. Both ultrasound contrast agents (UCAs) [13][14][15][16][17][18] and nanoparticles have been studied as methods to deliver cavitation nuclei into the targeted region.19,20 The use of UCA or nanoparticles, however, requires the systematic injection of foreign particles into the blood stream, and would have major concerns regarding toxicity, efficiency, etc. Cavitation bubbles can also be induced in presonication areas by using low frequency, high intensity ultrasound prior to HIFU treatments. 21,22 This technique can enhance cavitation and create larger size lesions in deep tissue without the injection of any contrast agents. However, this technique requires very high acoustic pressure (generally more than 10 MPa) to be delivered into soft tissues in order to induce cavitation in the beginning. In addition, the inception of cavitation is erratic and difficult to predict when induced by ultrasound alone.Laser light has been widely used as a reliable method to induce cavitation through optical breakdown. This procedure is generally performed with high intensity light, and mostly limited to clear media or sample surfaces. 23,24 Hence the application of this technique is limited in the in vivo applications, where treatments in a certain depth in turbid media are often desired.In a previous study, 25 we reported an enhanced heating effect during photoacoustic imaging-guided HIFU therapy. The results suggested that cavitation was enhanced when a diagnostic laser light beam illuminated the sample concurrently with HIFU radiation. Two features were highlighted...

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“…To generate microbubbles containing slightly soluble gas inside a body, the usage of nanoparticles that can be vaporized into microbubbles by HIFU pulses or short bursts has been developed and investigated [23,[37][38][39]. Such phase change nanoparticles enable us to control the region of microbubbles induced by HIFU pulses.…”

Section: Trigger Hifu Sequencementioning

confidence: 99%

Enhancement of High-Intensity Focused Ultrasound Heating by Short-Pulse Generated Cavitation

2017

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Abstract:A target tissue can be thermally coagulated in high-intensity focused ultrasound (HIFU) treatment noninvasively. HIFU thermal treatments have been clinically applied to various solid tumors. One of the problems in HIFU treatments is a long treatment time. Acoustically driven microbubbles can accelerate the ultrasonic heating, resulting in the significant reduction of the treatment time. In this paper, a method named "trigger HIFU exposure" which employs cavitation microbubbles is introduced and its results are reviewed. A trigger HIFU sequence consists of high-intensity short pulses followed by moderate-intensity long bursts. Cavitation bubbles induced in a multiple focal regions by rapidly scanning the focus of high-intensity pulses enhanced the temperature increase significantly and produced a large coagulation region with high efficiency.

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An in vitro Study of a Phase-Shift Nanoemulsion: A Potential Nucleation Agent for Bubble-Enhanced HIFU Tumor Ablation

Cited by 158 publications

References 82 publications

Enhanced-heating effect during photoacoustic imaging-guided high-intensity focused ultrasound

Enhanced-heating effect during photoacoustic imaging-guided high-intensity focused ultrasound

Laser-enhanced cavitation during high intensity focused ultrasound: An in vivo study

Enhancement of High-Intensity Focused Ultrasound Heating by Short-Pulse Generated Cavitation

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