1983
DOI: 10.1016/0006-2952(83)90055-2
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An in vitro study of hemicholinium-3 on phospholipid metabolism of Krebs II ascites cells

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1985
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Cited by 24 publications
(11 citation statements)
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“…In the case of HC3, both of these effects could be involved, because it has already been reported to be an inhibitor of choline penetration in other cellular systems, as well as an inhibitor of choline phosphorylation (3,8,16 On the other hand, the choline level is decreased by all of these compounds (Fig. 3).…”
Section: Resultsmentioning
confidence: 94%
“…In the case of HC3, both of these effects could be involved, because it has already been reported to be an inhibitor of choline penetration in other cellular systems, as well as an inhibitor of choline phosphorylation (3,8,16 On the other hand, the choline level is decreased by all of these compounds (Fig. 3).…”
Section: Resultsmentioning
confidence: 94%
“…However, HC-3 also a ects the biosynthesis of phosphorylcholine (PCho) by competitive inhibition of ChoK. In fact, HC-3 is actually also the most active inhibitor of ChoK known (Hamza et al, 1983;Cannon, 1994). In this study, we have generated new compounds based on the structure of HC-3 with much more potent inhibitory activity towards ChoK.…”
Section: Discussionmentioning
confidence: 99%
“…Hemicholinium-3 (HC-3) is a competitive inhibitor of ChoK due to its structural homology to choline (Hamza et al, 1983). The HC-3 structure, designated in this study as compound 1 (Figure 1), contains a central biphenyl ring to which two choline-like chains containing the quaternary groups are attached forming oxazinium rings in solution (Cannon, 1994).…”
Section: Generation Of New Choline Kinase Inhibitorsmentioning
confidence: 99%
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“…5) has been a prototype for ChoK inhibitors [97]. Prior to its study as a ChoK inhibitor, HC-3 was used as a research tool for its ability to inhibit acetylcholine synthesis in the nervous system [98].…”
Section: Choline Kinase Inhibitionmentioning
confidence: 99%