An in-vitro study of the effects of temperature on breast cancer cells: Experiments and models

Theriault, Christian; Paetzell, Emily; Chandrasekar, Rohith; Barkey, C.; Oni, Y.; Soboyejo, Winston O.

doi:10.1016/j.msec.2012.06.010

Cited by 12 publications

(13 citation statements)

References 58 publications

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“…It is known that in any biological system the temperature plays a crucial role in its dynamics, i.e. in the rate of cell division 37,38 . The use of the YGG nano-garnets as temperature nano-sensors in biological systems has the disadvantage that they must be functionalized before being introduced in aqueous media, in order to avoid the luminescence inhibition by the presence of OH-groups that interact with the optically active ions 39 .…”

Section: CD Ygg Nanocrystalline Garnet As Biological Optical Tempermentioning

confidence: 99%

“…This disadvantage is solved if the nano-garnets are coated with an insulating material, i.e. a silica shell, preventing the transfer of energy from the optically active RE 3+ ions to these impurities that generates channel of luminescence losses 38 . In this work, the Er 3+ -doped YGG nano-garnets were calibrated without the presence of this isolating material and, therefore they were not dissolved in any liquid.…”

Section: CD Ygg Nanocrystalline Garnet As Biological Optical Tempermentioning

confidence: 99%

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Optical nanothermometer based on the calibration of the Stokes and upconverted green emissions of Er³⁺ ions in Y₃Ga₅O₁₂ nano-garnets

et al. 2014

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The temperature-dependent green luminescence of Y 3 Ga 5 O 12 nano-garnets doped with different concentrations of Er 3+ ions has been measured from 300 to 850 K and, in more detail, in the biological range from 292 to 335 K. The green emissions were obtained exciting both under 488 nm blue or 800 nm near-infrared laser radiations. Both excitations give rise to bright green luminescence that can be seen by the naked eyes, and which can be associated either with Stokes processes, i.e. multiphonon relaxations followed by green spontaneous emission, in the former case or with infrared-to-visible upconversion processes in the latter one. The temperature-induced changes in the Er 3+ green emissions have been calibrated for both excitations and results point to a strong dependence on the concentration of optically active Er 3+ ions. The maximum value of the thermal sensitivity, 64 x 10 -4 K -1 at 547 K, has been obtained for the nano-garnets doped with the lowest concentration of Er 3+ ions, being one of the highest values found in the literature. These results allow concluding that a relatively low concentration of optically active ions is advisable and the changes induced by temperature on the green emissions are independent of the laser excitation radiation used, necessary to calibrate the temperature of the immediate environment of the Er 3+ -doped Y 3 Ga 5 O 12 nano-garnets.has been shown that the behavior of the green luminescence with the temperature is independent of the laser excitation wavelength, blue or near-infrared, used, although the latter is more suitable for biomedical applications.

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Section: CD Ygg Nanocrystalline Garnet As Biological Optical Tempermentioning

confidence: 99%

Section: CD Ygg Nanocrystalline Garnet As Biological Optical Tempermentioning

confidence: 99%

Optical nanothermometer based on the calibration of the Stokes and upconverted green emissions of Er³⁺ ions in Y₃Ga₅O₁₂ nano-garnets

et al. 2014

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“…Our implant for hyperthermia treatment, shown in Fig 2(a) , consists of a patterned metallic (copper) thin film (heater) embedded in a biocompatible polymer matrix (shell), poly-dimethylsiloxane (PDMS), substrate. Results of in-vitro hyperthermia studies obtained from this device, [ 14 ] showed that the device was able to kill or reduce the viability of breast cancer cells in the vicinity of the elevated temperature fields that surround it. Although the in-vitro cell experiments were promising, moving to in-vivo experiments required a proper understanding of the damage zones created by the device in biological media.…”

Section: Polymer-metal Compositesmentioning

confidence: 99%

Polymeric composite devices for localized treatment of early-stage breast cancer

2017

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For early-stage breast cancers mastectomy is an aggressive form of treatment. Therefore, there is a need for new treatment strategies that can enhance the use of lumpectomy by eliminating residual cancer cells with limited side effects to reduce local recurrence. Although, various radiotherapy-based methods have been developed, residual cells are found in 20–55% of the time at the first operation. Furthermore, some current treatment methods result in poor cosmesis. For the last decade, the authors have been exploring the use of polymeric composite materials in single and multi-modal implantable biomedical devices for post-operative treatment of breast cancer. In this paper, the concept and working principles of the devices, as well as selected results from experimental and numerical investigations, are presented. The results show the potential of the biomedical implants for cancer treatment.

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“…Physical injury by heat causes multiple levels of damage, leading to mutilation of cell membrane and cytoskeleton 76,77 . The membrane fluidity and potential gets affected after hyperthermia 78 ; and molecular changes like damage to intercellular proteins, generation of reactive oxygen species, increase in levels of heat shock proteins and damage to mitochondrial membrane has also been reported [79][80][81][82] . Transient heat treatments induce cytostatic processes where the cell temporarily gets arrested and division halts 80 .…”

Section: Lsmo Nanoparticles For Magnetic Fluid Hyperthermiamentioning

confidence: 99%

“…The membrane fluidity and potential gets affected after hyperthermia 78 ; and molecular changes like damage to intercellular proteins, generation of reactive oxygen species, increase in levels of heat shock proteins and damage to mitochondrial membrane has also been reported [79][80][81][82] . Transient heat treatments induce cytostatic processes where the cell temporarily gets arrested and division halts 80 . When dextran stabilized nanoparticles were used for hyperthermia treatment of human melanoma cell line-change in morphology, proliferation pattern and expression of heat shock proteins 70 and 90 were observed 83 .…”

Section: Lsmo Nanoparticles For Magnetic Fluid Hyperthermiamentioning

confidence: 99%

Lanthanum strontium manganese oxide (LSMO) nanoparticles: a versatile platform for anticancer therapy

2015

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Lanthanum Strontium Manganese oxide (LSMO) nanoparticles are a new class of magnetic nanoparticles, which exhibit favorable magnetic and biological properties for therapy using hyperthermia, imaging and diagnosis; opening avenues for multimodal anti-cancer therapy. Ease of synthesis and facile surface modifications makes LSMO nanoparticles a promising candidate for its application in anti-cancer therapy.

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An in-vitro study of the effects of temperature on breast cancer cells: Experiments and models

Cited by 12 publications

References 58 publications

Optical nanothermometer based on the calibration of the Stokes and upconverted green emissions of Er³⁺ ions in Y₃Ga₅O₁₂ nano-garnets

Optical nanothermometer based on the calibration of the Stokes and upconverted green emissions of Er³⁺ ions in Y₃Ga₅O₁₂ nano-garnets

Polymeric composite devices for localized treatment of early-stage breast cancer

Lanthanum strontium manganese oxide (LSMO) nanoparticles: a versatile platform for anticancer therapy

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An in-vitro study of the effects of temperature on breast cancer cells: Experiments and models

Cited by 12 publications

References 58 publications

Optical nanothermometer based on the calibration of the Stokes and upconverted green emissions of Er3+ ions in Y3Ga5O12 nano-garnets

Optical nanothermometer based on the calibration of the Stokes and upconverted green emissions of Er3+ ions in Y3Ga5O12 nano-garnets

Polymeric composite devices for localized treatment of early-stage breast cancer

Lanthanum strontium manganese oxide (LSMO) nanoparticles: a versatile platform for anticancer therapy

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Product

Resources

About

Optical nanothermometer based on the calibration of the Stokes and upconverted green emissions of Er³⁺ ions in Y₃Ga₅O₁₂ nano-garnets

Optical nanothermometer based on the calibration of the Stokes and upconverted green emissions of Er³⁺ ions in Y₃Ga₅O₁₂ nano-garnets