Lanthanum strontium manganese oxide (LSMO) nanoparticles: a versatile platform for anticancer therapy

Kulkarni, Vaishnavi; Bodas, Dhananjay; Paknikar, Kishore M.

doi:10.1039/c5ra02731d

Cited by 30 publications

(11 citation statements)

References 127 publications

(203 reference statements)

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“…LSM nanoparticles are spherical high surface metal particles that appear as a brown or black crystalline powder. Although numerous studies on LSM’s mechanical and electrical properties have been conducted [1, 3, 8, 9], very little research has focused on its biological effects [10–12]. Numerous nanoparticles have illustrated tendencies to promote mucus secretion and accumulation, thus are linked to respiratory illnesses [13, 14].…”

Section: Introductionmentioning

confidence: 99%

“…Research upon LSM nanoparticles shows promising ideas for biomedical applications [15–17]. Recently, research on LSM has shown its potential for anti-cancer therapy [12, 18, 19]. With the correct synthesis procedures and surface modifications, LSM has the ability to be a MRI contrast and hyperthermia agent as well as a drug carrier [20–22].…”

Section: Introductionmentioning

confidence: 99%

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Perovskite Nanoparticles Toxicity Study on Airway Epithelial Cells

et al. 2019

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Research on the toxicity of nanoparticles has developed over recent years due to their increasing prevalence in common everyday materials. Various nanoparticles have been reported to promote and induce mucus secretion, which could potentially lead to airway damages and respiratory complications. Lanthanum strontium manganite (LSM) is a nanoparticle widely used in solar oxidized fuel cells (SOFCs) due to its high electrical conductivity, high electrochemical activity for O2 reduction reaction, high thermal stability and compatibility of SOFC electrolytes, and most importantly, its microstructural stability and long-term performance. Very few studies have been conducted on LMS’s toxicity, thus its effect on airway cells was investigated in this study. After treating trachea cells with increasing concentrations of LSM ranging up to 500 μg/ml, we found that it has a moderate effect on cell viability, ROS production, cytochrome C, and caspase 3 expression. Despite its minimal impact on stated apoptosis-inducing characteristics, LSM illustrated an inhibiting effect on mucus secretion. We obtained a decreasing trend in mucus secretion with an increased concentration of the LSM treatment. Overall, LSM’s advancement in SOFCs necessitated a toxicity study, and although it does not show a significant toxicity to trachea cells, LSM reduces mucus secretion, and can potentially interfere with airway clearance.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Perovskite Nanoparticles Toxicity Study on Airway Epithelial Cells

et al. 2019

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“…LSMO NPs are ferromagnetic and have a high magnetization M and Curie temperature T C below 70 °C. This enables its use for MHT treatment of cancer with a possibility of in vivo temperature control . The T C value depends strongly on the Sr‐concentration x .…”

Section: Introductionmentioning

confidence: 99%

La_1−xSr_xMnO₃ Nanoparticles for Magnetic Hyperthermia

Apostolov

Apostolova

Wesselinowa

2018

Physica Status Solidi (b)

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Using a modified Heisenberg model and a Green's function technique we have studied the influence of size d and concentration x of Sr dopants on the Curie temperature T C , saturation magnetization M S , coercivity H C and specific absorption rate (SAR) of single-domain La 1Àx Sr x MnO 3 nanoparticles. Their magnetic properties are explained based on the "magnetically death" surface layer and the competition between the ferromagnetic double-exchange and antiferromagnetic super-exchange interaction. We calculated the specific absorption rate which characterizes the efficiency of the absorption energy when the magnetic hyperthermia is applied as a therapeutic method for the treatment of tumors. A set of nanoparticles appropriate for in vivo and in vitro medical applications, such as magnetic hyperthermia and drug delivery to cancer cells, is determined. The established methodology and microscopic model are suitable to study the magnetic properties of low-dimensional systems (thin films and nanoparticles) such as La 1Àx A x MnO 3 with A ¼ Ca, Ag, Ba, Na for medical applications.

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“…For the sake of achieving this purpose, the series of La 1− x Sr x MnO 3 (LSMO) compounds has attracted great interest in recent years [6–8]. The ferromagnetic–paramagnetic transition temperature T c (Curie temperature) of LSMO compounds is from 10 to 97 °C with the variation of Sr content [9]. Above the T c , MNPs lose the ability of generating caloric under magnetic field.…”

Section: Introductionmentioning

confidence: 99%

LSMO Nanoparticles Coated by Hyaluronic Acid for Magnetic Hyperthermia

et al. 2016

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Magnetic hyperthermia with the treating temperature range of 41–46 °C is an alternative therapy for cancer treatment. In this article, lanthanum strontium manganates (La1−xSrxMnO3, 0.25 ≤ × ≤ 0.35) magnetic nanoparticles coated by hyaluronic acid (HA) which possesses the ability of targeting tumor cells were prepared by a simple hydrothermal method combined with a high-energy ball milling technique. The crystal structure, morphology, magnetic properties of the HA-coated magnetic nanoparticles (MNPs), and their heating ability under alternating magnetic field were investigated. It was found the HA-coated La0.7Sr0.3MnO3, with particle diameter of ~100 nm, Curie temperature of 45 °C at a concentration 6 mg/ml, gave the optimal induction heating results. The heating temperature saturates at 45.7 °C, and the ESAR is 5.7 × 10−3 W/g · kHz · (kA/m2) which is much higher than other reported results.Electronic supplementary materialThe online version of this article (doi:10.1186/s11671-016-1756-3) contains supplementary material, which is available to authorized users.

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Lanthanum strontium manganese oxide (LSMO) nanoparticles: a versatile platform for anticancer therapy

Cited by 30 publications

References 127 publications

Perovskite Nanoparticles Toxicity Study on Airway Epithelial Cells

Perovskite Nanoparticles Toxicity Study on Airway Epithelial Cells

La_1−xSr_xMnO₃ Nanoparticles for Magnetic Hyperthermia

LSMO Nanoparticles Coated by Hyaluronic Acid for Magnetic Hyperthermia

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Lanthanum strontium manganese oxide (LSMO) nanoparticles: a versatile platform for anticancer therapy

Cited by 30 publications

References 127 publications

Perovskite Nanoparticles Toxicity Study on Airway Epithelial Cells

Perovskite Nanoparticles Toxicity Study on Airway Epithelial Cells

La1−xSrxMnO3 Nanoparticles for Magnetic Hyperthermia

LSMO Nanoparticles Coated by Hyaluronic Acid for Magnetic Hyperthermia

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Product

Resources

About

La_1−xSr_xMnO₃ Nanoparticles for Magnetic Hyperthermia