An in vivo dose-response study of fenbendazole against Oesophagostomum dentatum and Oesophagostomum quadrispinulatum in pigs

Praslička, J.; Bjørn, H.; Várady, Marián; Nansen, P.; Hennessy, D.R.; Talvik, H.

doi:10.1016/s0020-7519(96)00184-1

Cited by 12 publications

(8 citation statements)

References 12 publications

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“…In vitro egg hatch assays have been used to measure resistance both experimentally (Martin et al 1989) and as a field diagnostic aid (Le Jambre 1976, Ihler & Bjørn 1996, Geerts & Gryseels 2000. An in vitro larval development test (LDT) has been used to evaluate anthelmintic resistance in multiple mammalian species (Coles et al 1988, Praslicka et al 1997, Königová et al 2003, Várady et al 2006 and has been included in the guidelines of the World Association for the Advancement of Veterinary Parasitology (WAAVP) (Coles et al 1992). …”

Section: In Vitro Tests For Antiparasiticsmentioning

confidence: 99%

In vitro effect of seven antiparasitics on Acolpenteron ureteroecetes (Dactylogyridae) from largemouth bass Micropterus salmoides (Centrarchidae)

Reimschuessel¹,

Gieseker²,

Poynton³

2011

Dis. Aquat. Org.

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Few drugs are approved by the United States Food and Drug Administration for treating parasite infections in minor species such as fish, due in part to the high cost of developing such drugs and to a relatively small market share for drug sponsors. Because in vivo effectiveness trials for antiparasitic drugs are costly, time consuming, and use many animals, a systematic in vitro screening approach to describe parasite motility could help find promising drug candidates. We evaluated the effects of 7 antiparasitics on the activity and survival of the endoparasitic monogenean Acolpenteron ureteroecetes (Dactylogyridae) collected from the posterior kidneys of juvenile largemouth bass Micropterus salmoides (Lacepede, 1802) (Centrarchidae) held in the laboratory. Tests were conducted in 12 well tissue culture plates; each well had 3 parasites, and we tested 3 concentrations and 1 control for each of the 7 antiparasitics. The parasites were observed immediately after adding the drug, at 1 to 3 h, and 17 to 26 h, and video recordings were made. Drug effects were recorded by documenting morbidity (reduced movement, tremors, contracted body, abnormal morphology) and mortality. A. ureteroecetes was strongly affected by the quinoline praziquantel, the imidazothiazide levamisole, and the organophosphates dichlorvos and trichlorfon. The parasites were moderately affected by the macrocyclic lactones ivermectin and emamectin, and generally unaffected by the benzimidazole mebendazole. Our study demonstrates the utility of characterizing in vitro responses with video microscopy to document responses of fish parasites for initial screens of drug effects on a fish monogenean.

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Section: In Vitro Tests For Antiparasiticsmentioning

confidence: 99%

In vitro effect of seven antiparasitics on Acolpenteron ureteroecetes (Dactylogyridae) from largemouth bass Micropterus salmoides (Centrarchidae)

Reimschuessel¹,

Gieseker²,

Poynton³

2011

Dis. Aquat. Org.

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“…This amounts to the assumption that the nematodes in our model have not been previously exposed to the anthelmintic treatments under consideration; see, for example, [11]. We point out that the effect of the resistance in the dynamics is usually limited by the rotation of different anthelmintic classes on an annual basis (see [12,13]).…”

Section: Introductionmentioning

confidence: 99%

A Within-Host Stochastic Model for Nematode Infection

Gómez‐Corral

López‐García

2018

Mathematics

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Abstract:We propose a stochastic model for the development of gastrointestinal nematode infection in growing lambs under the assumption that nonhomogeneous Poisson processes govern the acquisition of parasites, the parasite-induced host mortality, the natural (no parasite-induced) host mortality and the death of parasites within the host. By means of considering a number of age-dependent birth and death processes with killing, we analyse the impact of grazing strategies that are defined in terms of an intervention instant t 0 , which might imply a move of the host to safe pasture and/or anthelmintic treatment. The efficacy and cost of each grazing strategy are defined in terms of the transient probabilities of the underlying stochastic processes, which are computed by means of Strang-Marchuk splitting techniques. Our model, calibrated with empirical data from Uriarte et al and Nasreen et al., regarding the seasonal presence of nematodes on pasture in temperate zones and anthelmintic efficacy, supports the use of dose-and-move strategies in temperate zones during summer and provides stochastic criteria for selecting the exact optimum time instant t 0 when these strategies should be applied.

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“…FEN is a broad spectrum benzimidazole anthelmintic prescribed worldwide in the treatment and prevention of several endoparasitic veterinary diseases. [1][2][3][4][5] However, in rare cases was used for humans. 6 Praziquantel (PRA), [2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino (2,1-a) isoquinolin-4-one], Figure 1, is a pyrazinoisoquinolone derivative which has been shown to be highly effective against a broad spectrum of cestode and trematode parasites in humans and animals.…”

Section: Introductionmentioning

confidence: 99%

Development of a Dissolution Test for Fenbendazole-Praziquantel Capsules Using UV-PLS Method

Vignaduzzo¹,

Operto²,

Castellano³

2016

J. Braz. Chem. Soc.

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A dissolution test for capsules containing 50 mg of praziquantel and 500 mg of fenbendazole was developed and validated. The optimal conditions were an USP apparatus 2 with paddles rotating at 75 rpm, 900 mL dissolution medium (a mixture of 300 mL of ethanol and 600 mL 0.5 mol L -1 HCl), at 37.0 ± 0.5 °C. Both analytes achieved with sink conditions. A published highperformance liquid chromatography (HPLC) method was used to monitoring dissolution test during the optimization. Additionally, a chemometrics method based on UV-VIS spectrophotometry and partial least-squares (PLS) was developed and validated for the simultaneous determination of both analytes in the dissolution media. The coefficients of determination were 0.9986 and 0.9959 for fenbendazole and praziquantel, respectively, and the elliptical joint confidence region (EJRC) test concluded that constant and proportional biases were absent. The optimized model was applied to build dissolution profile and its results did not show statistical differences with HPLC method.

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An in vivo dose-response study of fenbendazole against Oesophagostomum dentatum and Oesophagostomum quadrispinulatum in pigs

Cited by 12 publications

References 12 publications

In vitro effect of seven antiparasitics on Acolpenteron ureteroecetes (Dactylogyridae) from largemouth bass Micropterus salmoides (Centrarchidae)

In vitro effect of seven antiparasitics on Acolpenteron ureteroecetes (Dactylogyridae) from largemouth bass Micropterus salmoides (Centrarchidae)

A Within-Host Stochastic Model for Nematode Infection

Development of a Dissolution Test for Fenbendazole-Praziquantel Capsules Using UV-PLS Method

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