An increasing threat in intensive care units: evaluation of multi-drug-resistant Myroides spp. infections and risk factors

Gülmez, Abdurrahman; Ceylan, Ayşe Nur; Özalp, Onur

doi:10.1016/j.jhin.2023.04.010

Cited by 1 publication

(2 citation statements)

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“…Due to immune suppression and frequent exposure to the hospital setting, cancer patients have an increased risk of transmitting to infectious diseases, such as blood circulation. [42][43][44] In clinical applications, infections caused by Gram-positive bacteria are facing urgent situations of drug resistance; therefore, novel drugs that target Gram-positive MDR bacteria are highly anticipated. Gram-positive bacteria possess a thick layer of peptidoglycan, which boronic acid can bind through covalent bonds.…”

Section: Introductionmentioning

confidence: 99%

“…Bloodstream infections and staphylococcal infection are common among the patient. Due to immune suppression and frequent exposure to the hospital setting, cancer patients have an increased risk of transmitting to infectious diseases, such as blood circulation [42–44] . In clinical applications, infections caused by Gram‐positive bacteria are facing urgent situations of drug resistance; therefore, novel drugs that target Gram‐positive MDR bacteria are highly anticipated.…”

Section: Introductionmentioning

confidence: 99%

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The Use of Conjugated Gold Nanorods with Reduced Toxicity in Photothermal Therapy for MRSA

Yusufbeyoğlu,

Cinar,

Ildiz

et al. 2024

ChemistrySelect

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Methicillin‐resistant Staphylococcus aureus (MRSA) is one of the deadliest pathogenic bacteria. Using photothermal therapy (PTT) to eradicate MRSA bacteria easily and effectively, it has directed this bacterium to be destroyed. Gold nanorods (AuNRs), which are nanoparticles that provide PPT, were synthesized and removed from the CTAB molecule reduce the toxic effect caused by CTAB. Subsequently, mercaptophenylboronic acid (MFBA) coated AuNRs were synthesized and used in photothermal therapy to develop a targeting agent to selectively eliminate MRSA. A decrease in cytotoxic effect of CTAB@AuNRs after conjugation with MFBA was also demonstrated by the MTS cell viability test. We found that at the end of 48 hours and 72 hours of interaction, IC50 values of MFBA@ AuNR increased by approximately 50 % compared to CTAB@AuNR. Also, it shows that the cytotoxicity of AuNRs conjugated with MFBA was reduced. Herein, photothermal efficiency was achieved with MFBA@AuNRs targeting MRSA. The purpose of using and modifying gold nanorods is to reduce the toxicity of AuNRs and to examine their efficacy on resistant pathogenic bacteria strains by taking advantage of photothermal therapy properties.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%