Proceedings of the 8th European Congress of Neurosurgery, Barcelona, September 6–11, 1987 1988
DOI: 10.1007/978-3-7091-8978-8_41
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An Increment in Unilateral Carotid Blood Flow Produces Cerebral Aneurysms in Rats

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Cited by 6 publications
(3 citation statements)
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“…Although the mechanisms underlying the formation, growth, and rupture of aneurysms remain controversial, hemodynamic shear stress appears to be a principal aneurysmogenic factor. 1,6,9,18 Vascular casting is a powerful tool used to study arterial vascular systems; it avoids shrinkage artifacts and maintains a 3D geometry. Imprints of endothelial cell nuclei and endothelial cell borders can be clearly seen with the aid of a scanning electron microscope.…”
mentioning
confidence: 99%
“…Although the mechanisms underlying the formation, growth, and rupture of aneurysms remain controversial, hemodynamic shear stress appears to be a principal aneurysmogenic factor. 1,6,9,18 Vascular casting is a powerful tool used to study arterial vascular systems; it avoids shrinkage artifacts and maintains a 3D geometry. Imprints of endothelial cell nuclei and endothelial cell borders can be clearly seen with the aid of a scanning electron microscope.…”
mentioning
confidence: 99%
“…Then, in the late 80s, Roda and Alvarez ( 26 , 27 ) detailed better the influence of the hemodynamic stress on the IA incidence rate in rats, succeeding almost three times more in those animals which developed a higher carotid artery flow, thanks to the combination of unilateral CCA ligation and an end-to-side anastomosis between carotids, in comparison to those which underwent only unilateral CCA ligation ( Figure 2 ). Further, they demonstrated how this combination increased the blood flow through the parent carotid artery up to 89% in 5 months, inducing intracranial vessels damage ( 34 ).…”
Section: Experimental In Vivo Aneurysm Developmentmentioning
confidence: 98%
“…In most of the surgical hypertension-induced based models, branches of the renal arteries are surgical ligated ( 26 , 27 ), the rat is nephrectomized or its kidney is wrapped ( 20 ). According to this strategy, high-salt diet has been widely used.…”
Section: Experimental In Vivo Aneurysm Developmentmentioning
confidence: 99%