Endogenous animal models of intracranial aneurysm development: a review

Tutino, Vincent M.; Rajabzadeh-Oghaz, Hamidreza; Veeturi, Sricharan S.; Poppenberg, Kerry E.; Waqas, Muhammad; Mandelbaum, Max; Liaw, Nicholas; Siddiqui, Adnan H.; Meng, Hui; Kolega, John

doi:10.1007/s10143-021-01481-w

Cited by 14 publications

(21 citation statements)

References 223 publications

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“…Understanding of IA pathophysiology has been largely enabled by the use of small animal models (rat, mouse, rabbit) in which induced IA can mimic aspects of the human pathology. As such, induced IA are smaller than those found in humans thus, the above-mentioned imaging techniques are not widely used to analyze IA's dynamic and static characteristics ( 98 ). In fact, only a few studies use them other than as IA detection tools, for instance to detect macrophage infiltration or to perform CFD analysis on 3DRA images ( 77 , 99 ).…”

Section: Inflammation Imagingmentioning

confidence: 99%

Imaging Modalities for Intracranial Aneurysm: More Than Meets the Eye

Maupu

Lebas

Boulaftali

2022

Front. Cardiovasc. Med.

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Intracranial aneurysms (IA) are often asymptomatic and have a prevalence of 3 to 5% in the adult population. The risk of IA rupture is low, however when it occurs half of the patients dies from subarachnoid hemorrhage (SAH). To avoid this fatal evolution, the main treatment is an invasive surgical procedure, which is considered to be at high risk of rupture. This risk score of IA rupture is evaluated mainly according to its size and location. Therefore, angiography and anatomic imaging of the intracranial aneurysm are crucial for its diagnosis. Moreover, it has become obvious in recent years that several other factors are implied in this complication, such as the blood flow complexity or inflammation. These recent findings lead to the development of new IA imaging tools such as vessel wall imaging, 4D-MRI, or molecular MRI to visualize inflammation at the site of IA in human and animal models. In this review, we will summarize IA imaging techniques used for the patients and those currently in development.

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Section: Inflammation Imagingmentioning

confidence: 99%

Imaging Modalities for Intracranial Aneurysm: More Than Meets the Eye

Maupu

Lebas

Boulaftali

2022

Front. Cardiovasc. Med.

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“…Throughout history, there have been attempts for improving the available IA models by using different strategies, technologies, and animal species. Currently, there are two different classes for experimental development, considering the mechanism of production ( 20 ):…”

Section: Experimental In Vivo Aneurysm Developmentmentioning

confidence: 99%

“…On these grounds, nowadays, the precise mechanisms underlying IAintracranial aneurysm formation and rupture remain unclear, although most of the induction models are based on three main principles which can also be found in humans acting as risk factors: hypertension, hemodynamic changes, and vessel injury. Moreover, estrogen deficiency and genetic manipulation are increasing impact on all recent reviews ( 20 , 24 ). The combination of at least 2 or 3 of these methods is often described in the literature to improve the success rate, however, there is no international consensus about which is the best association.…”

Section: Experimental In Vivo Aneurysm Developmentmentioning

confidence: 99%

“…In most of the surgical hypertension-induced based models, branches of the renal arteries are surgical ligated ( 26 , 27 ), the rat is nephrectomized or its kidney is wrapped ( 20 ). According to this strategy, high-salt diet has been widely used.…”

Section: Experimental In Vivo Aneurysm Developmentmentioning

confidence: 99%

“…Deoxycorticosterone acetate-salt administration may have a dose-dependent effect, influencing both aneurysm formation and rupture ( 23 , 28 ). Despite being one of the favorite methods, by itself, the hypertension induction model is not enough to get an acceptable IA incidence rate ( 20 ).…”

Section: Experimental In Vivo Aneurysm Developmentmentioning

confidence: 99%

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Beyond Classic Anastomoses Training Models: Overview of Aneurysm Creation in Rodent Vessel Model

et al. 2022

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Nowadays, due to the decline in the number of microsurgical clippings for cerebral aneurysms and revascularization procedures, young neurosurgeons have fewer opportunities to participate and train on this type of surgery. Vascular neurosurgery is a demanding subspecialty that requires skills that can only be acquired with technical experience. This background pushes the new generations to be ready for such challenging cases by training hard on different available models, such as synthetic tubes, chicken wings, or placenta vessels. Although many training models for vascular neurosurgery have been described worldwide, one of the best is the rodent vessels model. It offers pulsation, coagulation, and real blood flow conditions in a physiologic atmosphere that mimics perfectly the intracranial human vessels environment, especially in terms of size. However, the current differences in governmental different regulations about the use of living animals in medical experimentation and the social awareness, as well as the lack of financial support, cause more difficulties for neurosurgeons to start with that kind of training. In this review, we describe the tools and techniques as basic steps for vascular microsurgery training by using rodent models, that provide an accurate copy of brain vessels environment under stable conditions. The initial three classical known microanastomoses for neurosurgeons are end-to-end, end-to-side, and side-to-side, but in literature, there have been described other more complex exercises for training and investigation, such as aneurysm models. Although there is still little data available, we aim to summarize and discuss aneurysm's training models and reviewed the current literature on the subject and its applications, including a detailed description of the techniques.

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