An indirect drug delivery device driven by piezoelectric pump

Chen, Song; Liu, Haidong; Ji, Jiajian; Kan, Junwu; Jiang, Yonghua; Zhang, Zhong Hua

doi:10.1088/1361-665x/ab8c23

Cited by 27 publications

(13 citation statements)

References 14 publications

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“…Chen et al developed an indirect piezoelectric micropump for drug delivery that consisted of a reusable piezoelectric actuator and a disposable drug delivery unit connected by a tube. 287 In this system, the drug fluids did not flow directly through the chamber in the pump, thereby reducing drug waste and contributing to environmental protection and cost reduction. The device outlet was connected to a needle, the diameter of which could influence the performance of the device for drug delivery.…”

Section: Microfluidic Micropumps For Drug Deliverymentioning

confidence: 99%

Microfluidics for Drug Development: From Synthesis to Evaluation

et al. 2021

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Drug development is a long process whose main content includes drug synthesis, drug delivery, and drug evaluation. Compared with conventional drug development procedures, microfluidics has emerged as a revolutionary technology in that it offers a miniaturized and highly controllable environment for bio(chemical) reactions to take place. It is also compatible with analytical strategies to implement integrated and high-throughput screening and evaluations. In this review, we provide a comprehensive summary of the entire microfluidics-based drug development system, from drug synthesis to drug evaluation. The challenges in the current status and the prospects for future development are also discussed. We believe that this review will promote communications throughout diversified scientific and engineering communities that will continue contributing to this burgeoning field.

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Section: Microfluidic Micropumps For Drug Deliverymentioning

confidence: 99%

Microfluidics for Drug Development: From Synthesis to Evaluation

et al. 2021

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“…Piezoelectric pumps are composed of a piezoelectric actuator and valve body (Chen et al, 2020;Kaynak et al, 2016;Li et al, 2021; J. T. Mohith et al, 2019;Opekar et al, 2016;Tang et al, 2019;Valdovinos et al, 2014;Wang et al, 2019;Y.-N. Wang & Fu, 2018;Yin et al, 2020). The actuator provides power for the fluid and the valve body plays a diversion role, so as to achieve unidirectional fluid pumping.…”

Section: Vpmgrf and Its Recirculating Flowmentioning

confidence: 99%

A novel valve-less piezoelectric micropump generating recirculating flow

Chen

Gui

et al. 2021

Engineering Applications of Computational Fluid Mechanics

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Microfluidic devices or systems to generate recirculating flow are increasingly utilized in the fields of chemistry, biomedicine, biology, with bottlenecks in integration and miniaturization needed a breakthrough. Here, a concept for a highly integrated valve-less piezoelectric micropump generating recirculating flow (VPMGRF) is proposed, simultaneously realizing innovation in theory and method. Based on fluid inertiaand energy dissipation of vortexes, a novel double-loop tube was designed to achieve fluid flow in different directions along various paths, with the flow characteristics at different cross-sectional areas explored through computational fluid dynamics (CFD). Afterwards, as valve bodies, the double-loop tubes were connected with a piezoelectric-actuated chamber to constitute the VPMGRF, which was followed by establishing a theoretical model of the vibration, fluid dynamics, and net flow rate. Eventually, experimental results showed that VPMGRFs could generate internal recirculating flow and had a pump effect. The maximum net flow rate reached 5.19 mL/min at 8 Hz, corresponding to a vibrator amplitude of 35 μm and an output pressure amplitude of 4.27 kPa. Furthermore, the larger the characteristic length of the cross section, the greater the amplitude of the vibrators, the larger the amplitude of output pressure, and the slower the flow rate.

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“…Pumps are considered powerful methods through which human beings to understand and transform the world [ 2 , 3 , 4 ]. Traditional pumps are driven by electric machinery; their disadvantages are their large volume, high power consumption, and lack of electromagnetic interference, which hinders their application in microfluidic and other fields [ 5 , 6 , 7 ]. With the development of the micro-electro-mechanical system (MEMS), micro pumps such as electrostatic pumps [ 8 , 9 ], thermally driven pumps [ 10 , 11 ], and piezoelectric pumps [ 12 , 13 ] have attracted wide attention.…”

Section: Introductionmentioning

confidence: 99%

“…Generally, the fluid is driven by the piezoelectric pump through the piezoelectric vibrator and special structures. It has the advantages of a simple structure [ 15 ], easy miniaturization [ 16 ], and no electromagnetic interference [ 17 ], leading to widespread use in microfluidic applications [ 5 , 6 , 7 ], medical equipment [ 18 , 19 , 20 ], fuel cells [ 21 , 22 , 23 ], and other fields. In terms of structure, piezoelectric pumps can be divided into valve-based piezoelectric pumps and valve-less piezoelectric pump [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Working Mechanisms and Experimental Research of Piezoelectric Pump with a Cardiac Valve-like Structure

Zhou

Sun²,

Fu³

et al. 2022

Micromachines

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In this study, based on the working principle of the cardiac valve structure that prevents blood from flowing back, a piezoelectric pump with a cardiac valve-like structure (PPCVLS) is designed. The operating principles of cardiac-valve-like structures (CVLSs) are introduced. Furthermore, the closure conditions of the CVLSs on both sides of the flow channel are explored. The principle behind the working-state conversion between “valve-based” and “valve-less” of PPCVLS is also analyzed. A high-speed dynamic microscopic image-analysis system was utilized to observe and verify the working-state conversion between “valve-based” and “valve-less” PPCVLSs. The resonant frequency of the piezoelectric pump was measured by Doppler laser vibrometer, and the optimal working frequency of the piezoelectric vibrator was determined as 22.35 Hz. The prototype piezoelectric pump was fabricated by the 3D printing technique, and the output performance of the piezoelectric pump was also evaluated. The experimental results show that the piezoelectric pump is valve-based when the driving voltage is greater than 140V, and the piezoelectric pump is valve-less when the driving voltage is less than 140 V. Furthermore, the maximum output pressure of the piezoelectric pump was 199 mm H2O when driven by the applied voltage of 220 V at 7 Hz, while the maximum flow rate of the piezoelectric pump was 44.5 mL/min when driven by the applied voltage of 220 V at 11 Hz.

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An indirect drug delivery device driven by piezoelectric pump

Cited by 27 publications

References 14 publications

Microfluidics for Drug Development: From Synthesis to Evaluation

Microfluidics for Drug Development: From Synthesis to Evaluation

A novel valve-less piezoelectric micropump generating recirculating flow

Working Mechanisms and Experimental Research of Piezoelectric Pump with a Cardiac Valve-like Structure

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