An Infectious Cutaneous Fibroma of the Virginia White-Tailed Deer (Odocoileus Virginianus)

Shope, Richard E.; Mangold, Robert; MacNamara, Lester G.; Dumbell, K. R.

doi:10.1084/jem.108.6.797

Cited by 30 publications

(18 citation statements)

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“…Though genital, cutaneous and oral papillomas (localized epithelium hyperplasia with a defined boundary and an intact basement membrane; Shah & Howley 1990) have been frequently described in odontocetes (Ge raci et al 1987, Lambertsen et al 1987, Bossart et al 1996, Van Bressem et al 1996, 1999, 2007b, Reh tanz et al 2006, Gottschling et al 2011, to the best of our knowledge, there are no published papers on cutaneous fibropapillomas in these marine mammals. Often caused by viruses in the family Papillomaviridae, fibropapillomas are commonly diagnosed on the skin of many terrestrial mammals including deer, camels, horses and zebras 1 where they can be plentiful and reach large sizes (Shope et al 1958, Sundberg & Nielsen 1981, Schulman et al 2003, Nel et al 2006. Whether papillomaviruses are implicated in the aetiology of fibropapillomas in O. brevirostris is possible, but requires further research.…”

Section: Malaysiamentioning

confidence: 99%

Cutaneous nodules in Irrawaddy dolphins: an emerging disease in vulnerable populations

Bressem¹,

Minton²,

Sutaria³

et al. 2014

Dis. Aquat. Org.

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The presence of cutaneous nodules is reported in vulnerable populations of Irrawaddy dolphins Orcaella brevirostris from Malaysia (Kuching, Bintulu-Similajau, KinabatanganSegama and Penang Island), India (Chilika Lagoon) and Bangladesh (Sundarbans). Approximately 5700 images taken for photo-identification studies in 2004 to 2013 were examined for skin disorders. Nodules were detected in 6 populations. They appeared as circumscribed elevations of the skin and varied in size from 2 to > 30 mm, were sparse or numerous and occurred on all visible body areas. In 8 photo-identified (PI) dolphins from India and Malaysia, the lesions remained stable (N = 2) or progressed (N = 6) over months but did not regress. The 2 most severely affected individuals were seen in Kuching and the Chilika Lagoon. Their fate is unknown. Cutaneous nodules were sampled in a female that died in a gillnet in Kuching in 2012. Histologically, the lesions consisted of thick collagen bundles covered by a moderately hyperplasic epithelium and were diagnosed as fibropapillomas. Whether the nodules observed in the other O. brevirostris were also fibropapillomas remains to be investigated. Disease prevalence ranged from 2.2% (N = 46; Bintulu-Similajau) to 13.9% (N = 72; Chilika) in 4 populations from Malaysia and India. It was not significantly different in 3 study areas in eastern Malaysia. In Chilika, prevalence was significantly higher (p = 0. well et al. 1975, Kiszka et al. 2009, Reif et al. 2009, Van Bressem et al. 2009b. In some small communities of inshore and estuarine populations, these pathologies are highly prevalent, may progress to cover extensive body areas and have been associated with the death or disappearance of severely affected individuals, including calves (Simões-Lopes et al. 1993, Van Bressem et al. 2007a, Kiszka et al. 2009, Daura-Jorge & Simões-Lopes 2011. However, their impact on the long-term viability of affected communities is still vastly unknown. The fungi Lacazia loboi, Fusarium spp., Paracoccidioides brasiliensis and Trichophyton spp. have been identified as the aetiological agents of some nodular disorders (Caldwell et al. 1975, Frasca et al. 1996, Van Bressem et al. 2007a, Esperón et al. 2012, Tanaka et al. 2012). Immune dysfunction is also known to play a role in the pathogenesis of L. loboi disease in coastal common bottlenose dolphins Tursiops truncatus from Florida, USA (Reif et al. 2009, Murdoch et al. 2010.Irrawaddy dolphins Orcaella brevirostris occur in large rivers and marine appended lakes in South Asia, as well as in the coastal waters of the Indo-Pacific Ocean (Smith 2009). Estuarine and nearshore populations are distributed in tropical and subtropical waters of the Indo-Pacific Ocean, from eastern India to the Philippines (Dolar et al. 2002, Minton et al. 2011. Riverine populations have been documented in 3 major river systems: the Mahakam (Indonesia), the Ayeyarwady (Myanmar) and the Mekong (Laos, Cambodia and Vietnam) (Smith 2009). Their habitat preference exposes them to multiple anthropog...

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Section: Malaysiamentioning

confidence: 99%

Cutaneous nodules in Irrawaddy dolphins: an emerging disease in vulnerable populations

Bressem¹,

Minton²,

Sutaria³

et al. 2014

Dis. Aquat. Org.

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“…PVs causing fibromas infect the host through skin lesions as demonstrated by experimental studies (Shope, 1955;Shope et al, 1958;Sundberg et al, 1985a). After inoculation, the virus induces proliferation of fibroblasts at the entry site (Sundberg and Nielsen, 1981) developing into well-defined, usually multiple cutaneous tumours on virtually any part of the body surface.…”

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“…Fibropapillomatosis is caused by papillomaviruses (PVs) which are non-enveloped, icosahedral viruses, 50-55 nm in diameter, with a circular, double-stranded DNA genome, ranging from 7.4 to 8.6 kb. Besides the number of PVs identified in domestic animals several PVs have been described from fibropapillomas of wild cervid species such as whitetailed deer (Shope et al, 1958;Lancaster and Sundberg, 1982), mule deer (Lancaster and Sundberg, 1982), European elk (Moreno-Lopez et al, 1981), reindeer (Moreno-Lopez et al, 1987), red deer (McDiarmid, 1975;Moar and Jarrett, 1985), and roe deer (Erdélyi et al, 2008). Fibromatosis has been seen in Hungarian populations of roe deer (Takács and Nagy-Bozsoky, 1998;Kocsner, 2001;Erdélyi et al, 2008) and red deer (Hőnich et al, 1978).…”

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“…The epidermis on white-tailed deer fibromas often shows signs of acanthosis, focal hyperplasia of the stratum granulosum, hyper-and parakeratosis, while polygonal fibroblasts of the main tumour mass produce large amounts of collagen fibres (Sundberg and Nielsen, 1981;Sundberg et al, 1985b). Fibromas are benign tumours, they rarely form metastases and they generally do not influence the host's body condition (Shope et al, 1958;Sundberg and Nielsen, 1981). Roe deer fibromatosis is also characterised by the formation of multiple, benign skin tumours of varying size localised predominantly on the extremities and the head.…”

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confidence: 99%

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Papillomavirus-associated fibropapillomas of red deer ( Cervus elaphus )

Erdélyi

Gál

Sugár

et al. 2009

Acta Veterinaria Hungarica

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Oval, firm, cutaneous tumours with a rough, hairless, pigmented surface, exhibiting a moderately pronounced papillary structure were detected on the abdominal skin of two young red deer (Cervus elaphus). One animal was shot in Lower Austria in 2004, the other at a deer farm in Hungary in 2007. Histological examination of both samples classified the tumours as fibropapillomas, showing marked proliferation of fibroblasts and connective tissue, accompanied by hyperkeratosis, parakeratosis and acanthosis of the overlaying epidermis, and occasional foci of inflammation. The distribution of cytokeratin and vimentin was characterised in the lesion. The presence of papillomavirus (PV) antigen was demonstrated by immunohistochemistry in both cases. Papillomavirus-specific DNA was successfully amplified by PCR from one sample. The obtained partial nucleotide sequence of the L2 ORF exhibited the highest critical identity values with the homologous regions of Delta-papillomaviruses, especially the Roe deer papillomavirus (93%). Phylogenetic analysis of the partial L2 ORF sequence alignment of 10 papillomaviruses by both neighbour-joining and maximum parsimony method confirmed that the Red deer PV is very closely related to the Western roe deer papillomavirus (CcPV1).

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“…Although such neoplasms have been re ported for red deer, they have been unambi guously classified as either papilloma or fi broma; the latter seems to be identical by macroscopic and histologic criteria to the cutaneous fibroma of the American white tailed deer [4][5][6][7]Jennings,personal commun. ].…”

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A Cutaneous Fibropapilloma from a Red Deer (<i>Cervus elaphus</i>) Associated with a Papillomavirus

Moar

Jarrett

1985

Intervirology

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A cutaneous fibropapilloma was found on a Scottish red deer (Cervus elaphus), and a papillomavirus was isolated from it. The virus appeared to be related to bovine papillomavirus type 1 (BPVl) or type 2 (BPV2) because: (i) it cross-reacted in peroxidase-antiperoxidase tests with antisera raised against these virions; (ii) BPVl and BPV2 DNAs cross-hybridized to the red deer papillomavirus in situ; and (iii) BPVl and/or BPV2 DNA cross-hybridized to the red deer papillomavirus DNA on Southern blots under conditions of high stringency. These tests also revealed a unique restriction enzyme cleavage pattern for the red deer papillomavirus DNA.

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An Infectious Cutaneous Fibroma of the Virginia White-Tailed Deer (Odocoileus Virginianus)

Cited by 30 publications

References 1 publication

Cutaneous nodules in Irrawaddy dolphins: an emerging disease in vulnerable populations

Cutaneous nodules in Irrawaddy dolphins: an emerging disease in vulnerable populations

Papillomavirus-associated fibropapillomas of red deer ( Cervus elaphus )

A Cutaneous Fibropapilloma from a Red Deer (<i>Cervus elaphus</i>) Associated with a Papillomavirus

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