An injectable, dual crosslinkable hybrid pectin methacrylate (PECMA)/gelatin methacryloyl (GelMA) hydrogel for skin hemostasis applications

Wang, Jinghan; Tsai, Ching-Wen; Tsai, Nian-Yun; Chiang, Chao-Ying; Lin, Ru-Sin; Pereira, Rúben F.; Li, Yi-Chen Ethan

doi:10.1016/j.ijbiomac.2021.06.162

Cited by 60 publications

(26 citation statements)

References 45 publications

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“…Gel-MA was also related to the C-N-H vibratory bond, and the band within the range of 3200-3400 cm-1 revealed the peptide bonds (mainly stretching NH bonding) [38]. The formation of the dressings was verified by the following bands; the wide absorption band at 1630 cm-1 was related to C=O stretching and the band at 1542 cm-1 was attributed to the stretching vibration of C-N-H [39]. Moreover, the absorption band from the hydroxyl unit (-OH) near 3300 cm-1 was observed in the spectra of Gel-MA, which meant the reduced number of hydrogen double bonds because of the reaction of amino units (-NH) in Gel after the reaction with the methlacrylate group [39,40].…”

Section: Resultsmentioning

confidence: 93%

Assessment of Centella Asiatica Extract Containing Dual-crosslinked Gel-MA/Pec Hydrogels as Wound Dressing

ALBAYRAK>

GELAL>

Akalgan

et al. 2022

Hittite Journal of Science and Engineering

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In the present work, 3D-printed wound dressings containing different amounts of Centella Asiatica extract were synthesized via dual-crosslinking method. Methacrylic anhydride modified gelatin (Gel-MA) and pectin (Pec) were chosen as the base material for dressings. A dual crosslinked network was formed with Gel-MA photo-crosslinking using Irgacure 2959 and Pectin (Pec) psychical-crosslinking using Ca++ ions. Meanwhile, the developed dual-crosslinked hydrogel dressings were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, and mechanical, swelling, in vitro degradation as well as ex vivo bioadhesion tests. It has been observed that the preapred dressings provide good bioadhesion on the chicken skin. Moreover, MTT assay revealed cell viability of Gel-MA/Pec hydrogel dressings containing Centella Asiatica extract. The results presented the dressings as a promising biomaterial to be used for wound healing purposes, which should be further investigated in future.

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Section: Resultsmentioning

confidence: 93%

Assessment of Centella Asiatica Extract Containing Dual-crosslinked Gel-MA/Pec Hydrogels as Wound Dressing

ALBAYRAK>

GELAL>

Akalgan

et al. 2022

Hittite Journal of Science and Engineering

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“…An in vitro porcine skin bleeding model confirmed that the hydrogel could be injected directly into the wound and rapidly photo-crosslinked, and reduce the coagulation time by 39%. Importantly, the hydrogel can be easily removed to prevent secondary injury to the wound [92,93]. In another study, Yang et al developed a photo-crosslinked multifunctional antibacterial and antioxidant hemostatic hydrogel dressing.…”

Section: Skinmentioning

confidence: 99%

Advances in Hemostatic Hydrogels That Can Adhere to Wet Surfaces

Han

Wang

2022

Gels

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Currently, uncontrolled bleeding remains a serious problem in emergency, surgical and battlefield environments. Despite the specific properties of available hemostatic agents, sealants, and adhesives, effective hemostasis under wet and dynamic conditions remains a challenge. In recent years, polymeric hydrogels with excellent hemostatic properties have received much attention because of their adjustable mechanical properties, high porosity, and biocompatibility. In this review, to investigate the role of hydrogels in hemostasis, the mechanisms of hydrogel hemostasis and adhesion are firstly elucidated, the adhesion design strategies of hemostatic hydrogels in wet environments are briefly introduced, and then, based on a comprehensive literature review, the studies and in vivo applications of wet-adhesive hemostatic hydrogels in different environments are summarized, and the improvement directions of such hydrogels in future studies are proposed.

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“…Swellable hydrogels can absorb blood plasma to concentrate blood clotting factors locally and to trigger the coagulation process . Injectable hydrogels provide versatile platforms for chemical functionalization and mechanical tunability . However, the blood clotting time scale for dry wound dressings is generally shorter than that for hydrogels. , As a result, ongoing research seeks effective biomaterial design strategies for bleeding management using injectable hydrogels with particular attention to their wet tissue adhesive properties.…”

Section: Introductionmentioning

confidence: 99%

Engineered Hemostatic Biomaterials for Sealing Wounds

et al. 2022

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Hemostatic biomaterials show great promise in wound control for the treatment of uncontrolled bleeding associated with damaged tissues, traumatic wounds, and surgical incisions. A surge of interest has been directed at boosting hemostatic properties of bioactive materials via mechanisms triggering the coagulation cascade. A wide variety of biocompatible and biodegradable materials has been applied to the design of hemostatic platforms for rapid blood coagulation. Recent trends in the design of hemostatic agents emphasize chemical conjugation of charged moieties to biomacromolecules, physical incorporation of blood-coagulating agents in biomaterials systems, and superabsorbing materials in either dry (foams) or wet (hydrogel) states. In addition, tough bioadhesives are emerging for efficient and physical sealing of incisions. In this Review, we highlight the biomacromolecular design approaches adopted to develop hemostatic bioactive materials. We discuss the mechanistic pathways of hemostasis along with the current standard experimental procedures for characterization of the hemostasis efficacy. Finally, we discuss the potential for clinical translation of hemostatic technologies, future trends, and research opportunities for the development of next-generation surgical materials with hemostatic properties for wound management.

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An injectable, dual crosslinkable hybrid pectin methacrylate (PECMA)/gelatin methacryloyl (GelMA) hydrogel for skin hemostasis applications

Cited by 60 publications

References 45 publications

Assessment of Centella Asiatica Extract Containing Dual-crosslinked Gel-MA/Pec Hydrogels as Wound Dressing

Assessment of Centella Asiatica Extract Containing Dual-crosslinked Gel-MA/Pec Hydrogels as Wound Dressing

Advances in Hemostatic Hydrogels That Can Adhere to Wet Surfaces

Engineered Hemostatic Biomaterials for Sealing Wounds

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