An injectable multi-responsive hydrogel as self-healable and on-demand dissolution tissue adhesive

Sigen, A; Xu, Qian; Johnson, Melissa; Creagh-Flynn, Jack; Venet, Manon; Zhou, Daohong; Lara-Sáez, Irene; Tai, Hongyun; Wang, Wenxin

doi:10.1016/j.apmt.2021.100967

Cited by 35 publications

(13 citation statements)

References 29 publications

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“…214 In another work, Wang et al presented a multiresponsive adhesive hydrogel for on-demand dissolvable wound dressings. 215 This hydrogel was prepared from the Schiff base bonding between aldehyde-functionalized HA and a disulfide-containing cross-linker (3,3-dithiobis(propionic hydrazide)), and the introduction of disulfide bonds made hydrogels exhibit gel−sol transformation toward strain, reduction, oxidation, enzyme, and UV light (Figure 11C). Thus, the adhesive hydrogels could be removed in a minimally invasive manner.…”

Section: Dynamic Covalent Linkage-functionalized Adhesive Hydrogelsmentioning

confidence: 99%

Supramolecular Adhesive Hydrogels for Tissue Engineering Applications

et al. 2022

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Tissue engineering is a promising and revolutionary strategy to treat patients who suffer the loss or failure of an organ or tissue, with the aim to restore the dysfunctional tissues and enhance life expectancy. Supramolecular adhesive hydrogels are emerging as appealing materials for tissue engineering applications owing to their favorable attributes such as tailorable structure, inherent flexibility, excellent biocompatibility, near-physiological environment, dynamic mechanical strength, and particularly attractive self-adhesiveness. In this review, the key design principles and various supramolecular strategies to construct adhesive hydrogels are comprehensively summarized. Thereafter, the recent research progress regarding their tissue engineering applications, including primarily dermal tissue repair, muscle tissue repair, bone tissue repair, neural tissue repair, vascular tissue repair, oral tissue repair, corneal tissue repair, cardiac tissue repair, fetal membrane repair, hepatic tissue repair, and gastric tissue repair, is systematically highlighted. Finally, the scientific challenges and the remaining opportunities are underlined to show a full picture of the supramolecular adhesive hydrogels. This review is expected to offer comparative views and critical insights to inspire more advanced studies on supramolecular adhesive hydrogels and pave the way for different fields even beyond tissue engineering applications.

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Section: Dynamic Covalent Linkage-functionalized Adhesive Hydrogelsmentioning

confidence: 99%

Supramolecular Adhesive Hydrogels for Tissue Engineering Applications

et al. 2022

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“…Furthermore, the release of glyphosate from the hydrogel under environmental stimuli displayed regulatable behaviors. Multi-responsive properties such as redox-responsive, enzyme-responsive, and UV-responsive properties were introduced into an adhesive hydrogel composed of aldehyde functionalized HA and a disulfide containing cross-linker-3,3′-dithiobis(propionic hydrazide) . A cellulose-based multi-responsive hydrogel was made of the facile incorporation of enamine and disulfide bonds at a physiological pH.…”

Section: Preparation and Different Types Of Stimuli-responsive Polysa...mentioning

confidence: 99%

“…Multi-responsive properties such as redox-responsive, enzyme-responsive, and UV-responsive properties were introduced into an adhesive hydrogel composed of aldehyde functionalized HA and a disulfide containing cross-linker-3,3′-dithiobis(propionic hydrazide). 137 A cellulose-based multi-responsive hydrogel was made of the facile incorporation of enamine and disulfide bonds at a physiological pH. The cellulose hydrogel exhibited reversible sol−gel transitions in response to pH and redox stimulus.…”

Section: ■ Introductionmentioning

confidence: 99%

Recent Advances of Stimuli-Responsive Polysaccharide Hydrogels in Delivery Systems: A Review

Zhang

Dong

Liu

et al. 2022

J. Agric. Food Chem.

106

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Hydrogels obtained from natural polymers have received widespread attention for their excellent biocompatible property, nontoxicity, easy gelation, and functionalization. Polysaccharides can regulate the gut microbiota and improve the intestinal microenvironment, thus exerting the healthy effect of intestinal immunity. In an active substance delivery system, the extent and speed of the substance reaching its target are highly dependent on the carrier. Thus, the smart active substance delivery systems are gradually increasing. The smart polysaccharide-hydrogels possess the ability in response to external stimuli through changing their volume phase and structure, which are applied in various fields. Natural polysaccharide-based hydrogels possess excellent characteristics of environmental friendliness, good biocompatibility, and abundant sources. According to the response type, natural polysaccharide-based hydrogels are usually divided into stimulus-responsive hydrogels, including internal response (pH, temperature, enzyme, redox) and external response (light, electricity, magnetism) hydrogels. The delivery system based on polysaccharides can exert their effects in the gastrointestinal tract. At the same time, polysaccharides may also take part in regulating the brain signals through the microbiota-gut-brain axis. Therefore, natural polysaccharide-hydrogels are considered as promising biomaterials, which can be designed as delivery systems for regulating the gut-brain axis. This article reviews the research advance of stimulus-responsive hydrogels, which focus on the types, response characteristics, and applications for polysaccharide-based smart hydrogels as delivery systems.

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“…As the esophagus is a soft tissue with peristalsis and swallowing functions, higher requirements are put forward for the glue used to bond the multi-layer esophageal scaffold (>>10 kPa and >>10 Jm −2 ). New adhesives, such as nano-clay/multi-walled carbon nanotubes/isopropylacrylamide hydrogel (adhesive strength 7 kPa) ( Deng et al, 2019 ), sodium p-styrene sulfonate/chloromethane quaternized dimethylaminoethyl acrylate hydrogel (adhesive strength 25 kPa, adhesive energy 50 Jm -2 ) ( Rao et al, 2018 ), chitosan/double-bonded phenylalanine hydrogel (adhesive strength 14 kPa) ( Sharma et al, 2019 ), aldehyde functionalized hyaluronic acid/3,3′-dithiobis (propionyl hydrazide) hydrogel (adhesive strength 120 kPa) ( Sigen et al, 2021 ), polyethylene glycol/lysozyme hydrogel (adhesive strength 32 kPa) ( Tan et al, 2019 ), folic acid/polydimethyl diallyl ammonium chloride hydrogel (adhesive strength 150 kPa) ( Gao et al, 2021 ), and hyaluronic acid/catechol/horseradish peroxidase hydrogels (17 kPa) ( Wang D. et al, 2020 ) ( Figure 7 ), are used. The hydrogels mentioned above can only meet one of the requirements of adhesion or cytocompatibility.…”

Section: Problems and Challengesmentioning

confidence: 99%

“…Adhesion experiments of aldehyde-functionalized hyaluronic acid/3,3′-dithiobis (propionyl hydrazide) hydrogels. (G,J) Hydrogels adhered to various substrate surfaces ( Sigen et al, 2021 ).…”

Section: Problems and Challengesmentioning

confidence: 99%

Development and Prospect of Esophageal Tissue Engineering

Fang

et al. 2022

Front. Bioeng. Biotechnol.

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Currently, patients with esophageal cancer, especially advanced patients, usually use autologous tissue for esophageal alternative therapy. However, an alternative therapy is often accompanied by serious complications such as ischemia and leakage, which seriously affect the prognosis of patients. Tissue engineering has been widely studied as one of the ideal methods for the treatment of esophageal cancer. In view of the complex multi-layer structure of the natural esophagus, how to use the tissue engineering method to design the scaffold with structure and function matching with the natural tissue is the principle that the tissue engineering method must follow. This article will analyze and summarize the construction methods, with or without cells, and repair effects of single-layer scaffold and multi-layer scaffold. Especially in the repair of full-thickness and circumferential esophageal defects, the flexible design method and the binding force between the layers of the scaffold are very important. In short, esophageal tissue engineering technology has broad prospects and plays a more and more important role in the treatment of esophageal diseases.

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An injectable multi-responsive hydrogel as self-healable and on-demand dissolution tissue adhesive

Cited by 35 publications

References 29 publications

Supramolecular Adhesive Hydrogels for Tissue Engineering Applications

Supramolecular Adhesive Hydrogels for Tissue Engineering Applications

Recent Advances of Stimuli-Responsive Polysaccharide Hydrogels in Delivery Systems: A Review

Development and Prospect of Esophageal Tissue Engineering

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