An Injectable Strong Hydrogel for Bone Reconstruction

Bone is a hard yet dynamic tissue with remarkable healing capacities. Research to date has greatly advanced the understanding of how bone heals and has led to marked success in the treatment of bone injuries. Nevertheless, the effective treatment of nonunions and large bone defects continues to present a challenge for orthopedic surgeons. Biomaterials provide researchers with a powerful instrument to potentially guide effective bone tissue regeneration in challenging healing environments. However, the most appropriate biomaterial for bone tissue engineering continues to be an area of intense debate. Indeed, the mechanical properties of real bone can be reproduced in vitro but the development of a functional bone substitute goes beyond the sole mechanical properties. The faithful reproduction of bone as a functional organ requires the combination of different cell types and temporal regulation of the molecular signaling involved during the different stages of bone formation and regeneration. This is not at all a trivial task. Herein, critical aspects of bone healing/regeneration including mechanical loading, inflammation, vascularization, and innervation are described. The success and the challenges behind the development of biomaterials, and the technologies used to functionalize them, in order to support the underlying cellular mechanisms are also highlighted.

show abstract

“…Additionally, the material demonstrated cytocompatibility and osteogenic potential when tested in vivo. [403]…”

Section: Interpenetrating Polymer Networkmentioning

confidence: 99%

“…Nevertheless, it achieved superior performance demonstrated by a compressive strength, modulus, and fracture energy of 34, 0.8, and 40 kJ m −2 respectively. Additionally, the material demonstrated cytocompatibility and osteogenic potential when tested in vivo 403…”

Section: Strategies To Improve Biomaterials For Bone Regenerationmentioning

confidence: 99%

Functional Biomaterials for Bone Regeneration: A Lesson in Complex Biology

Armiento

Hatt

Rosenberg

et al. 2020

Adv Funct Materials

166

View full text Add to dashboard Cite

show abstract

“…Similarly, Zhao et al proposed injectable dual crosslinking hydrogels to act as bone-filling materials. [151] They selected BG microspheres as inorganic phases and incorporated them into polymer networks by hydrogen bonding. Mineralization in vitro showed an "autostrengthen" phenomenon of mechanical properties and in vivo tests demonstrated osteogenesis in the defect.…”

Section: Inorganic Particles Loadingmentioning

confidence: 99%

Recent Advances in Injectable Dual Crosslinking Hydrogels for Biomedical Applications

Chu

Nie

et al. 2021

Macromolecular Bioscience

View full text Add to dashboard Cite

Injectable dual crosslinking hydrogels hold great promise to improve therapeutic efficacy in minimally invasive surgery. Compared with prefabricated hydrogels, injectable hydrogels can be implanted more accurately into deeply enclosed sites and repair irregularly shaped lesions, showing great applicable potential. Here, the current fabrication considerations of injectable dual crosslinking hydrogels are reviewed. Besides, the progress of the hydrogels used in corresponding applications and emerging challenges are discussed, with detailed emphasis in the fields of bone and cartilage regeneration, wound dressings, sensors and other less mentioned applications for their more hopeful employments in clinic. It is envisioned that the further development of the injectable dual crosslinking hydrogels will catalyze their innovation and transformation in the biomedical field.

show abstract

“…The microspheres can be loaded into the composite scaffold and evenly distributed in the scaffold. [ 118 ] Dou et al. prepared hydroxyapatite collagen (HC) column composite scaffolds with microspheres.…”

Section: Medical Applicationsmentioning

confidence: 99%

Preparation of Single, Heteromorphic Microspheres, and Their Progress for Medical Applications

Zhang

Wang

et al. 2020

Macro Materials & Eng

View full text Add to dashboard Cite

Microspheres applied in medical applications experience explosive development in recent years, such as drug release, cell culture, and bone tissue engineering, etc. However, there are still some bottlenecks both in economy and technology lay that cannot be ignored. For instance, microsphere technology has not been used in cell culture widely because of its uneconomical cost; as the core of drug‐loaded microsphere, targeted microsphere technology is still not mature enough. Besides, the common microsphere fabrication methods: microfluidic or emulsion technology is difficult to guarantee high biocompatibility of microsphere due to utilization of photoinitiator, crosslinking agent, surfactant, and other substances. Therefore, gas‐shearing technology has been proposed to solve these above shortcomings successfully. This paper focuses more on heteromorphic microspheres rather than on single microspheres which begins with a minute introduction of microsphere preparation methods: microfluidic, coaxial electrospray, emulsion, and gas‐shearing technology. Then its medical applications: drug release, cell culture, bone tissue engineering, and hemostasis are discussed in detail. The disadvantages of fabrication methods and bottlenecks for medical applications at present are also stated. At the end, perspectives of microsphere development are put forward.

show abstract

An Injectable Strong Hydrogel for Bone Reconstruction

Cited by 87 publications

References 40 publications

Functional Biomaterials for Bone Regeneration: A Lesson in Complex Biology

Functional Biomaterials for Bone Regeneration: A Lesson in Complex Biology

Recent Advances in Injectable Dual Crosslinking Hydrogels for Biomedical Applications

Preparation of Single, Heteromorphic Microspheres, and Their Progress for Medical Applications

Contact Info

Product

Resources

About