An injectable thermosensitive polymeric hydrogel for sustained release of Avastin® to treat posterior segment disease

Xie, Binbin; Jin, Ling; Luo, Zichao; Yu, Jing; Shi, Shuai; Zhang, Zhaoliang; Shen, Meixiao; Chen, Hao; Li, Xingyi; Song, Zongming

doi:10.1016/j.ijpharm.2015.05.071

Cited by 98 publications

(61 citation statements)

References 33 publications

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“…Injectable hydrogels are one kind of novel biomedical materials that keep fluid state outside body and transform into gels after injection into body [15,99,100]. Injectable hydrogels are ideal therapeutic materials because they can be loaded with therapeutic agents and form a 3D network in situ at the diseased sites, forming a drug release depot for pharmaceutics [101,102]. Injectable hydrogels usually need external stimuli such as temperature or pH to trigger the sol-gel phase transition [102][103][104].…”

Section: Pnipam-based Composite Hydrogels For Drug Deliverymentioning

confidence: 99%

Poly(N-isopropylacrylamide)-Based Thermoresponsive Composite Hydrogels for Biomedical Applications

Liu

Fu³

et al. 2020

Polymers

262

146

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Poly(N-isopropylacrylamide) (PNIPAM)-based thermosensitive hydrogels demonstrate great potential in biomedical applications. However, they have inherent drawbacks such as low mechanical strength, limited drug loading capacity and low biodegradability. Formulating PNIPAM with other functional components to form composited hydrogels is an effective strategy to make up for these deficiencies, which can greatly benefit their practical applications. This review seeks to provide a comprehensive observation about the PNIPAM-based composite hydrogels for biomedical applications so as to guide related research. It covers the general principles from the materials choice to the hybridization strategies as well as the performance improvement by focusing on several application areas including drug delivery, tissue engineering and wound dressing. The most effective strategies include incorporation of functional inorganic nanoparticles or self-assembled structures to give composite hydrogels and linking PNIPAM with other polymer blocks of unique properties to produce copolymeric hydrogels, which can improve the properties of the hydrogels by enhancing the mechanical strength, giving higher biocompatibility and biodegradability, introducing multi-stimuli responsibility, enabling higher drug loading capacity as well as controlled release. These aspects will be of great help for promoting the development of PNIPAM-based composite materials for biomedical applications.

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Section: Pnipam-based Composite Hydrogels For Drug Deliverymentioning

confidence: 99%

Poly(N-isopropylacrylamide)-Based Thermoresponsive Composite Hydrogels for Biomedical Applications

Liu

Fu³

et al. 2020

Polymers

262

146

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“…Most hydrogel platforms have not only shown to be biocompatible but also allow a sustained release of bioactive anti-VEGF to the retina for durations of multiple months [91,92,[98][99][100][101][102] (Table 2). Yu et al developed a hydrogel system comprised of natural polymers.…”

Section: Hydrogels For Sustained Delivery Of Anti-vegfmentioning

confidence: 99%

Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases

Seah

Zhao

Lin

et al. 2020

Eye

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Anti-vascular endothelial growth factors (anti-VEGF) have become the most common treatment modality for many retinal diseases. These include neovascular age-related macular degeneration (n-AMD), proliferative diabetic retinopathy (PDR) and retinal vein occlusions (RVO). However, these drugs are administered via intravitreal injections that are associated with sight-threatening complications. The most feared of these complications is endophthalmitis, a severe infection of the eye with extremely poor visual outcomes. Patients with retinal diseases typically have to undergo multiple injections before achieving the desired therapeutic effect. Each injection incurs the risk of the sight-threatening complications. As such, there has been great interest in developing sustained delivery platforms for anti-VEGF agents to the posterior segment of the eye. In recent years, there have been various strategies that have been conceptualised. These include non-biodegradable implants, nano-formulations and hydrogels. In this review, the barriers of drug delivery to the posterior segment of the eye will be explained. The characteristics of an ideal sustained delivery platform will then be discussed. Finally, the current available strategies will be analysed with the above-mentioned characteristics in mind to determine the advantages and disadvantages of each sustained drug delivery modality. Through the above, this review attempts to provide an overview of the sustained delivery platforms in their various phases of development.These authors contributed equally: Ivan Seah Yu Jun, Zhao Xin Xin 1234567890();,:1234567890();,:

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“…Thus, this technology has the potential to reduce administration time, increase patient medication adherence and reduce therapeutic expenses 28,29. Several injectable sustained-release preparations have been developed, including for analgesic and endomyocardial applications, the steroid amcinonide, polypeptides, vaccines and gene-targeting drugs 30,31…”

Section: Discussionmentioning

confidence: 99%

Protection Provided by a Gabexate Mesylate Thermo-SensitiveIn SituGel for Rats with Grade III Pancreatic Trauma

Gao

Song

et al. 2017

Gut and Liver

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Background/AimsThis study investigated the protection provided by gabexate mesylate thermo-sensitive in-situ gel (GMTI) against grade III pancreatic trauma in rats.MethodsA grade III pancreatic trauma model with main pancreatic duct dividing was established, and the pancreas anatomical diagram, ascites, and serum biochemical indices, including amylase, lipase, C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α), were examined. The pancreas was sliced and stained with hematoxylin eosin and subjected to terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining.ResultsAscites, serum amylase, lipase, CRP, IL-6, and TNF-α levels were significantly increased in the pancreas trauma (PT) groups with prolonged trauma time and were significantly decreased after GMTI treatment. The morphological structure of the pancreas was loose, the acinus was significantly damaged, the nuclei were irregular and hyperchromatic, and there was inflammatory cell invasion in the PT group compared to the control. After GMTI treatment, the morphological structure of the pancreas was restored, and the damaged acinus and inflammatory cell invasion were decreased compared to the PT group. Moreover, the cell apoptosis index was significantly increased in the PT group and restored to the same levels as the control group after GMTI treatment.ConclusionsGMTI, a novel formulation and drug delivery method, exhibited specific effective protection against PT with acute pancreatitis therapy and has potential value as a minimally invasive adjuvant therapy for PT with acute pancreatitis.

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An injectable thermosensitive polymeric hydrogel for sustained release of Avastin® to treat posterior segment disease

Cited by 98 publications

References 33 publications

Poly(N-isopropylacrylamide)-Based Thermoresponsive Composite Hydrogels for Biomedical Applications

Poly(N-isopropylacrylamide)-Based Thermoresponsive Composite Hydrogels for Biomedical Applications

Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases

Protection Provided by a Gabexate Mesylate Thermo-SensitiveIn SituGel for Rats with Grade III Pancreatic Trauma

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